The single-cell eQTLGen consortium

In recent years, functional genomics approaches combining genetic information with bulk RNA-sequencing data have identified the downstream expression effects of disease-associated genetic risk factors through so-called expression quantitative trait locus (eQTL) analysis. Single-cell RNA-sequencing creates enormous opportunities for mapping...

Linear and Non-Linear Dynamics of a Micro-ramp Wake

Micro-ramps are deployed to prevent boundary layer separation by creating a momentum excess close to the wall. Through Direct Numerical Simulations (DNS) of the base, instantaneous and mean flow, we identify that the perturbation dynamics in the wake of the microramp play an essential role in creating the near-wall momentum excess. To identify...

Transitional Flow Dynamics Behind a Micro-Ramp

Micro-ramps are popular passive flow control devices which can delay flow separation by re-energising the lower portion of the boundary layer. We compute the laminar base flow, the instantaneous transitional flow, and the mean flow around a micro-ramp immersed in a quasi-incompressible boundary layer at supercritical roughness Reynolds number...

Transitional flow dynamics behind a micro-ramp

We computed the base, instantaneous and mean flow around a micro-ramp immersed in an incompressible boundary layer. Results of our Direct<br/>Numerical Simulations (DNS) are compared with an independent stability analysis and experiments. We analyse flow structures and mechanisms that contribute to the micro-ramp functionality and find that...