The role of epidemic spreading in seizure dynamics and epilepsy surgery

Epilepsy surgery is the treatment of choice for drug-resistant epilepsy patients, but only leads to seizure freedom for roughly two in three patients. To address this problem, we designed a patient-specific epilepsy surgery model combining large-scale magnetoencephalography (MEG) brain networks with an epidemic spreading model. This simple...

Epidemic models characterize seizure propagation and the effects of epilepsy surgery in individualized brain networks based on MEG and invasive EEG recordings

Epilepsy surgery is the treatment of choice for drug-resistant epilepsy patients. However, seizure-freedom is currently achieved in only 2/3 of the patients after surgery. In this study we have developed an individualized computational model based on MEG brain networks to explore seizure propagation and the efficacy of different virtual...

Hidden invariant convexity for global and conic-intersection optimality guarantees in discrete-time optimal control

Non-convex discrete-time optimal control problems in, e.g., water or power systems, typically involve a large number of variables related through nonlinear equality constraints. The ideal goal is to find a globally optimal solution, and numerical experience indicates that algorithms aiming for Karush–Kuhn–Tucker points often find solutions...

Optimization of epilepsy surgery through virtual resections on individual structural brain networks

The success of epilepsy surgery in patients with refractory epilepsy depends upon correct identification of the epileptogenic zone (EZ) and an optimal choice of the resection area. In this study we developed individualized computational models based upon structural brain networks to explore the impact of different virtual resections on the...

Convex modeling of pumps in order to optimize their energy use

This study presents convex modeling of drainage pumps so that real-time control systems can be implemented to minimize their energy use. A convex model is built based on pump curves and then used in mixed-integer optimization to allow pumps to be turned on or off. It is implemented as an extension to the open source software package RTC-Tools...

Geometric trajectory tracking control