Combined Chemoradionuclide Therapy Using Poly(ε-caprolactone-b-ethylene oxide) Micelles as the Delivery Vehicle

Combination of therapies is a common strategy in cancer treatment. Such combined therapies only have merit provided that there is superior therapeutic outcome with fewer side effects, compared to single therapies. Here, this work explores the possibility to combine chemotherapy with radionuclide therapy using polymeric micelles as a delivery...

Efficient Radiolabeling of Block Copolymer Micelles through Radiometal Salt Precipitation for Theranostic Applications

A variety of polymer micelles are designed for the delivery of chemotherapeutic drugs to tumors. Although the promise of these nanocarriers is very high, in the clinic the effectivity is rather limited. Determining the in vivo fate of the micelles can greatly help to improve this treatment. Here, a simple and fast chelator-free method for...

Ionizing Radiation-Induced Release from Poly(ϵ-caprolactone- b-ethylene glycol) Micelles

Polymeric micelles, due to their easy preparation and versatile properties, have been widely applied as one of the most popular carriers for chemotherapeutic agents. Such micelles primarily prevent the leakage of drugs during transportation and thus protect healthy tissue. Controlled drug release, which releases the drugs at the site of...

Singlet Oxygen Sensor Green is not a Suitable Probe for ¹O₂ in the Presence of Ionizing Radiation

A great number of fluorescent probes have been developed for detecting singlet oxygen (¹O₂), which is considered to be one of the most effective reactive oxygen species (ROS), especially in clinical applications. The commercially available fluorescent probe Singlet Oxygen Sensor Green (SOSG) is widely used due to its...