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Odendaal, Kirsten (author), Alkemade, Aaron (author), Kana, A.A. (author)The adverse human contribution to global climate change has forced the yachting industry to acknowledge the need to reduce its environmental impact due to the client's increasing pressure and potential future regulations to limit the ecological effects. Unfortunately, current real-world data presents a significant disparity between predicted...journal article 2023
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Alkemade, Puck (author), Eijsvogels, Thijs M.H. (author), Janssen, Thomas W.J. (author), Jansen, K.M.B. (author), Kingma, Boris R.M. (author), Daanen, Hein A.M. (author)PURPOSE: For wheelchair users with a spinal cord injury, the lower body may be a more convenient cooling site than the upper body. However, it remains unknown if leg cooling reduces thermal strain in these individuals. We compared the impact of upper-body versus lower-body cooling on physiological and perceptual outcomes during submaximal arm...journal article 2023
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Alkemade, C. (author), Wierenga, H. (author), Volkov, V. (author), López, Magdalena Preciado (author), Akhmanova, Anna (author), ten Wolde, Pieter Rein (author), Dogterom, A.M. (author), Koenderink, G.H. (author)The actin and microtubule cytoskeletons form active networks in the cell that can contract and remodel, resulting in vital cellular processes such as cell division and motility. Motor proteins play an important role in generating the forces required for these processes, but more recently the concept of passive cross-linkers being able to...journal article 2022
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Linder, Simon (author), Hoogstraat, Marlous (author), Stelloo, Suzan (author), Eickhoff, Nils (author), Schuurman, Karianne (author), de Barros, Hilda (author), Alkemade, Maartje (author), Bekers, Elise M. (author), Wessels, L.F.A. (author)In prostate cancer, androgen receptor (AR)–targeting agents are very effective in various disease stages. However, therapy resistance inevitably occurs, and little is known about how tumor cells adapt to bypass AR suppression. Here, we performed integrative multiomics analyses on tissues isolated before and after 3 months of AR-targeting...journal article 2022
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Alkemade, C. (author)The human body is composed of about 3−4×1013 (30-40 trillion) cells [1]. These cells are all functioning consistently, and working elegantly together, to sustain the organism. Not only humans, but all other living things on earth (from plants to parrots) are composed of cells. Cells are the smallest living building blocks of plants and animals,...doctoral thesis 2021
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Culmone, C. (author), Lussenburg, K.M. (author), Alkemade, J.P.E. (author), Smit, G. (author), Sakes, A. (author), Breedveld, P. (author)In the field of medical instruments, additive manufacturing allows for a drastic reduction in the number of components while improving the functionalities of the final design. In addition, modifications for users’ needs or specific procedures become possible by enabling the production of single customized items. In this work, we present the...journal article 2021
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Moret, J. L.T.M. (author), Alkemade, J. (author), Upcraft, T. M. (author), Paulssen, E. (author), Wolterbeek, H.T. (author), van Ommen, J.R. (author), Denkova, A.G. (author)New production routes for <sup>99</sup>Mo are steadily gaining importance. However, the obtained specific activity is much lower than currently produced by the fission of U-235. To be able to supply hospitals with <sup>99</sup>Mo/<sup>99m</sup>Tc generators with the desired activity, the adsorption capacity of the column material should be...journal article 2020
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Bazin, Pierre Louis (author), Nijsse, Hannah E. (author), van der Zwaag, Wietske (author), Gallichan, Daniel (author), Alkemade, Anneke (author), Vos, F.M. (author), Forstmann, Birte U. (author), Caan, Matthan W.A. (author)Sub-millimeter imaging at 7T has opened new possibilities for qualitatively and quantitatively studying brain structure as it evolves throughout the life span. However, subject motion introduces image blurring on the order of magnitude of the spatial resolution and is thus detrimental to image quality. Such motion can be corrected for, but...journal article 2020
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Crisp, R.W. (author), Hashemi, Fatemeh S.M. (author), Alkemade, J. (author), Kirkwood, N.R.M. (author), Grimaldi, G. (author), Kinge, S.S. (author), Siebbeles, L.D.A. (author), van Ommen, J.R. (author), Houtepen, A.J. (author)To improve the stability and carrier mobility of quantum dot (QD) optoelectronic devices, encapsulation or pore infilling processes are advantageous. Atomic layer deposition (ALD) is an ideal technique to infill and overcoat QD films, as it provides excellent control over film growth at the sub-nanometer scale and results in conformal...journal article 2020
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Martinez Torres, C.E. (author), Burla, F. (author), Alkemade, C. (author), Koenderink, G.H. (author)Filamentous proteins are responsible for the superior mechanical strength of our cells and tissues. The remarkable mechanical properties of protein filaments are tied to their complex molecular packing structure. However, since these filaments have widths of several to tens of nanometers, it has remained challenging to quantitatively probe...journal article 2019
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van de Willige, Dieudonnée (author), Hummel, Jessica J.A. (author), Alkemade, C. (author), Kahn, Olga I. (author), Au, Franco K.C. (author), Qi, Robert Z. (author), Dogterom, A.M. (author), Koenderink, G.H. (author), Hoogenraad, Casper C. (author), Akhmanova, Anna (author)Crosstalk between the actin and microtubule cytoskeletons underlies cellular morphogenesis. Interactions between actin filaments and microtubules are particularly important for establishing the complex polarized morphology of neurons. Here, we characterized the neuronal function of growth arrest-specific 2-like 1 (Gas2L1), a protein that can...journal article 2019
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Lahabi, K. (author), Amundsen, Morten (author), Ouassou, Jabir Ali (author), Beukers, Ewout (author), Pleijster, Menno (author), Linder, Jacob (author), Alkemade, P.F.A. (author), Aarts, Jan (author)Spin-triplet Cooper pairs induced in ferromagnets form the centrepiece of the emerging field of superconducting spintronics. Usually the focus is on the spin-polarization of the triplets, potentially enabling low-dissipation magnetization switching. However, the magnetic texture which provides the fundamental mechanism for generating triplets...journal article 2017
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Nanda, G. (author), Hlawacek, Gregor (author), Goswami, S. (author), Watanabe, Kenji (author), Taniguchi, Takashi (author), Alkemade, P.F.A. (author)We report the etching of and electronic transport in nanoribbons of graphene sandwiched between atomically flat hexagonal boron nitride (h-BN). The etching of ribbons of varying width was achieved with a focused beam of 30 keV He<sup>+</sup> ions. Using in-situ electrical measurements, we established a critical dose of 7000 ions nm<sup>−2<...journal article 2017
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van der Walle, P (author), Kramer, E. (author), van der Donck, J.C.J. (author), Mulckhuyse, W (author), Nijsten, L. (author), Bernal Arango, F.A. (author), de Jong, A. (author), van Zeijl, E. (author), Spruit, H. E.T. (author), van den Berg, J.H. (author), Nanda, G. (author), van Langen-Suurling, A.K. (author), Alkemade, P.F.A. (author), Pereira, S.F. (author), Maas, D.J. (author)Particle defects are important contributors to yield loss in semi-conductor manufacturing. Particles need to be detected and characterized in order to determine and eliminate their root cause. We have conceived a process flow for advanced defect classification (ADC) that distinguishes three consecutive steps; detection, review and...conference paper 2017
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- Holtz, G (author), Alkemade, F (author), de Haan, F (author), Kohler, J (author), Trutnevyte, E (author), Luthe, T (author), Halbe, J (author), Papachristos, G. (author), Chappin, E.J.L. (author), Kwakkel, J.H. (author), Ruutu, S (author) journal article 2016
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- Nanda, G. (author), Veldhoven, E. van (author), Maas, D. (author), Herfst, R. (author), Sadeghian Marnani, H. (author), Alkemade, P.F.A. (author) abstract 2016
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Bouwens, MAJ (author), Maas, D (author), van der Donck, JCJ (author), Alkemade, P.F.A. (author), van der Walle, P (author)To qualify tools of semiconductor manufacturing, particles unintentionally deposited in these tools are character-ized using blank wafers. With fast optical inspection tools one can quickly localize these particle defects. An ex-ample is TNO's Rapid Nano, which operates in optical darkfield. The next step is defect review for further...journal article 2016
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Nanda, G. (author), Van Veldhoven, E. (author), Maas, D. (author), Sadeghian, H. (author), Alkemade, P.F.A. (author)The authors report the direct-write growth of hammerhead atomic force microscope(AFM) probes by He+beam induced deposition of platinum-carbon. In order to grow a thin nanoneedle on top of a conventional AFM probe, the authors move a focused He+beam during exposure to a PtC precursor gas. In the final growth stage, a perpendicular movement of the...journal article 2015
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Overweg, H.C. (author), Den Haan, A.M.J. (author), Eerkens, H.J. (author), Alkemade, P.F.A. (author), La Rooij, A.L. (author), Spreeuw, R.J.C. (author), Bossoni, L. (author), Oosterkamp, T.H. (author)We investigate the degradation of the magnetic moment of a 300?nm thick FePt film induced by Focused Ion Beam (FIB) milling. A 1??m?×?8??m rod is milled out of a film by a FIB process and is attached to a cantilever by electron beam induced deposition. Its magnetic moment is determined by frequency-shift cantilever magnetometry. We find that the...journal article 2015
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Holtz, G. (author), Alkemade, F. (author), De Haan, F. (author), Köhler, J. (author), Trutnevyte, E. (author), Luthe, T. (author), Halbe, J. (author), Papachristos, G. (author), Chappin, E. (author), Kwakkel, J.H. (author), Ruutu, S. (author)Societal transitions involve multiple actors, changes in institutions, values and technologies, and interactions across multiple sectors and scales. Given this complexity, this paper takes on the view that the societal transitions research field would benefit from the further maturation and broader uptake of modelling approaches. This paper...journal article 2015