Thermodynamic Effects in Enzyme Regulation, Stereochemistry and Process Control

Thiamine diphosphate dependent enzymes are excellent catalysts for the asymmetric synthesis of the α-hydroxyketone (acyloin) structural motif, which is found in many pharmaceuticals and fine chemicals. In chapter 2, variants of transketolase from Saccharomyces cerevisiae were screened for the conversion of aliphatic aldehydes with...