Simultaneously Improved Bendability and Strength of Al–Mg–Si–Cu–Zn Alloys by Controlling the Formation and Evolution of Primary Fe-Rich Phase

In present work, the formation, evolution, and distribution of the primary Fe-rich phase in an Al–Mg–Si–Cu–Zn–Fe–Mn alloy are coupling controlled by ultrasonic melt treatment (USMT) and thermomechanical processing (TMP). It is shown in the results that the size of grains and Fe-rich phase in the as-cast state can be greatly reduced by the...

Multi-omics integrative analysis with genome-scale metabolic model simulation reveals global cellular adaptation of Aspergillus niger under industrial enzyme production condition

Oxygen limitation is regarded as a useful strategy to improve enzyme production by mycelial fungus like Aspergillus niger. However, the intracellular metabolic response of A. niger to oxygen limitation is still obscure. To address this, the metabolism of A. niger was studied using multi-omics integrated analysis based on the latest GEMs ...

Integrated isotope-assisted metabolomics and ¹³C metabolic flux analysis reveals metabolic flux redistribution for high glucoamylase production by Aspergillus niger

Background: Aspergillus niger is widely used for enzyme production and achievement of high enzyme production depends on the comprehensive understanding of cell's metabolic regulation mechanisms. Results: In this paper, we investigate the metabolic differences and regulation mechanisms between a high glucoamylase-producing strain A. niger...