Synergistic effects of cerium-containing bioactive glasses and apoptotic extracellular vesicles alleviate bisphosphonate-related osteonecrosis of jaw

Bisphosphonates (BPs) are commonly used to treat skeletal diseases. However, long-term use of BPs can lead to BP-related jaw bone necrosis (BRONJ), particularly in patients undergoing tooth extraction surgery. The treatment of BRONJ remains challenging due to the local inflammatory microenvironment. To address this issue, we developed...

Precision Engineering of the Co-immobilization of Enzymes for Cascade Biocatalysis

The design and orderly layered co-immobilization of multiple enzymes on resin particles remain challenging. In this study, the SpyTag/SpyCatcher binding pair was fused to the N-terminus of an alcohol dehydrogenase (ADH) and an aldo-keto reductase (AKR), respectively. A non-canonical amino acid (ncAA), p-azido-L-phenylalanine (p-AzF), as the...

Assessment of Vigilance Level during Work: Fitting a Hidden Markov Model to Heart Rate Variability

This study aimed to enhance the real-time performance and accuracy of vigilance assessment by developing a hidden Markov model (HMM). Electrocardiogram (ECG) signals were collected and processed to remove noise and baseline drift. A group of 20 volunteers participated in the study. Their heart rate variability (HRV) was measured to train...

Direct ink writing of vascularized self-healing cementitious composites

Direct ink writing of cementitious materials can be an alternative way for creating vascular self-healing concrete by intentionally incorporating hollow channels in the cementitious matrix. In this study, a 3D-printable fibre reinforced mortar was first developed. Three groups of specimens were fabricated using direct ink writing, where the...

Designing an enzyme assembly line for green cascade processes using bio-orthogonal chemistry

Two non-canonical amino acids (ncAAs) with bio-orthogonal reactive groups, namely, p-azido-l-phenylalanine (p-AzF) and p-propargyloxy-l-phenylalanine (p-PaF), were genetically inserted into an aldo-keto reductase (AKR) and an alcohol dehydrogenase (ADH), respectively, at two preselected sites for each enzyme. The variants were expressed in...

Supplementary control based on current source coupling for improving dynamic characteristics of active distribution network

Supplementary control (SC) technology is widely leveraged by power supply companies in active distribution networks (ADNs) to improve their stability and dynamic characteristics. Yet, the existed SCs are generally implemented from inside the converter controllers of distributed generators (DGs) or active loads, so there is a need to redesign...

Novel Solid-State Sodium-Ion Battery with Wide Band Gap NaTi₂(PO₄)₃ Nanocrystal Electrolyte

NaTi2(PO4)3 (NTP), a well-known anode material, could be used as a solid wide-band gap electrolyte. Herein, a novel solid-state sodium-ion battery (SSIB) with the thickness of electrolyte up to the millimeter level is proposed. The results of the difference in charge density investigated by the first-principles calculations imply that using...

Chemical and rheological properties of polymer modified bitumen incorporating bio-oil derived from waste cooking oil

The chemical and rheological properties of polymer modified bitumen incorporating bio-oil derived from waste cooking oil (WCO) were investigated in this paper. At first, the chemical composition and mixing mechanism of the experimental materials were analysed from the perspective of functional group, and the influence of bio-oil on the...

Removal of Microcystis aeruginosa by UV-activated persulfate: Performance and characteristics

Cyanobacteria blooms in source waters have become a worldwide issue for drinking water production. UV-activated persulfate (UV/PS) technology was firstly applied to remove cultivated Microcystis aeruginosa (M. aeruginosa) in bench scale. The presence of persulfate significantly enhanced both cytoclasis and algal organic matter mineralization...

UV/persulfate preoxidation to improve coagulation efficiency of Microcystis aeruginosa

The performance of UV-activated persulfate (UV/PS) technology as preoxidation process to enhanceMicrocystis aeruginosa removal by subsequent coagulation-sedimentation was firstly evaluated. Theresults demonstrate that UV/PS preoxidation could successfully promote coagulation of algae cellsthrough the effective neutralization of zeta potential,...