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Sensory weighting of position and force feedback during pinching

Geelen, J.E. (author), van der Helm, F.C.T. (author), Schouten, A.C. (author), Mugge, W. (author)

Human hands are complex biomechanical systems that allow for dexterous tasks with many degrees of freedom. Coordination of the fingers is essential for many activities of daily living and involves integrating sensory signals. During this sensory integration, the central nervous system deals with the uncertainty of sensory signals. When...

journal article 2023

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Quantifying Joint Stiffness During Movement: A Quantitative Comparison of Time-Varying System Identification Methods

van de Ruit, M.L. (author), Mugge, W. (author), Schouten, A.C. (author)

Careful control of joint impedance, or dynamic joint stiffness, is crucial for successful performance of movement. Time-varying system identification (TV-SysID) enables quantification of joint impedance during movement. Several TV-SysID methods exist, but have never been systematically compared. Here, we simulate time-varying joint behavior...

book chapter 2022

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Closing the loop: Novel quantitative fMRI approach for manipulation of the sensorimotor loop in tremor

Sharifi, S. (author), Luft, F. (author), de Boer, L. (author), Buijink, A. W.G. (author), Mugge, W. (author), Schouten, A.C. (author), Heida, T. (author), Bour, L. J. (author), van Rootselaar, A. F. (author)

Tremor is thought to be an effect of oscillatory activity within the sensorimotor network. To date, the underlying pathological brain networks are not fully understood. Disentangling tremor activity from voluntary motor output and sensorimotor feedback systems is challenging. To better understand the intrinsic sensorimotor fingerprint...

journal article 2022

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Combining ultrafast ultrasound and high-density EMG to assess local electromechanical muscle dynamics: a feasibility study

Waasdorp, R. (author), Mugge, W. (author), Vos, H.J. (author), De Groot, Jurriaan H. (author), Verweij, M.D. (author), de Jong, N. (author), Schouten, A.C. (author), Daeichin, V. (author)

Skeletal muscles generate force, enabling movement through a series of fast electro-mechanical activations coordinated by the central nervous system. Understanding the underlying mechanism of such fast muscle dynamics is essential in neuromuscular diagnostics, rehabilitation medicine and sports biomechanics. The unique combination of...

journal article 2021

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Quantitative comparison of time-varying system identification methods to describe human joint impedance

van de Ruit, M.L. (author), Mugge, W. (author), Cavallo, Gaia (author), Lataire, John (author), Ludvig, Daniel (author), Schouten, A.C. (author)

Accurate and swift tuning of joint impedance is crucial to perform movement and interaction with our environment. Time-varying system identification enables quantification of joint impedance during movement. Many methods have been developed over the years, each with their own mathematical approach and underlying assumptions. Yet, for the...

journal article 2021

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Directionality of corticomuscular coupling in essential tremor and cortical myoclonic tremor

Sharifi, S. (author), Luft, F. (author), Potgieter, S. (author), Heida, T. (author), Mugge, W. (author), Schouten, A.C. (author), Bour, L. J. (author), van Rootselaar, A. F. (author)

Objective: A role of the motor cortex in tremor generation in essential tremor (ET) is assumed, yet the directionality of corticomuscular coupling is unknown. Our aim is to clarify the role of the motor cortex. To this end we also study ‘familial cortical myoclonic tremor with epilepsy’ (FCMTE) and slow repetitive voluntary movements with a...

journal article 2021

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MarkerLess Motion Capture: ML-MoCap, a low-cost modular multi-camera setup

Geelen, J.E. (author), Branco, Mariana P. (author), Ramsey, Nick F. (author), van der Helm, F.C.T. (author), Mugge, W. (author), Schouten, A.C. (author)

Motion capture systems are extensively used to track human movement to study healthy and pathological movements, allowing for objective diagnosis and effective therapy of conditions that affect our motor system. Current motion capture systems typically require marker placements which is cumbersome and can lead to contrived movements.Here, we...

conference paper 2021

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A long-term effect of distal radius fracture on the sensorimotor control of the wrist joint in older adults

Muurling, Marijn (author), Lötters, Freek J.B. (author), Geelen, J.E. (author), Schouten, A.C. (author), Mugge, W. (author)

Introduction: Sensorimotor control can be disturbed because of pain and trauma. There is scarce comprehension about which component of the sensorimotor system would benefit the most from treatment in distal radius fracture (DRF). Purpose of the Study: The purpose of this study was to determine whether the sensorimotor control of subjects with...

journal article 2021

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Distinct cortical activity patterns in Parkinson's disease and essential tremor during a bimanual tapping task

Luft, Frauke (author), Sharifi, Sarvi (author), Mugge, W. (author), Schouten, A.C. (author), Bour, Lo J. (author), Van Rootselaar, Anne Fleur (author), Veltink, Peter H. (author), Heida, Tijtske (author)

Background: Parkinson's disease (PD) and essential tremor (ET) are neurodegenerative diseases characterized by movement deficits. Especially in PD, maintaining cyclic movement can be significantly disturbed due to pathological changes in the basal ganglia and the cerebellum. Providing external cues improves timing of these movements in PD and...

journal article 2020

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System identification of ankle joint dynamics based on plane-wave ultrasound muscle imaging

Ossenkoppele, B.W. (author), Daeichin, V. (author), Rodriguez Hernandez, K.E. (author), de Jong, N. (author), Verweij, M.D. (author), Schouten, A.C. (author), Mugge, W. (author)

Effective treatment of movement disorders requires thorough understanding of human limb control. Joint dynamics can be assessed using robotic manipulators and system identification. Due to tendon compliance, joint angle and muscle length are not proportional. This study uses plane-wave ultrasound imaging to investigate the dynamic relation...

conference paper 2019

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Tracking electromechanical muscle dynamics using ultrafast ultrasound and high-density EMG

Waasdorp, R. (author), Mugge, W. (author), Vos, H.J. (author), de Groot, J.H. (author), de Jong, N. (author), Verweij, M.D. (author), Schouten, A.C. (author), Daeichin, V. (author)

Current methods to track the progression and evaluate treatment of muscular dystrophies are scarce. The electromechanical delay (EMD), defined as the time lag from muscle electrical activity to motion onset, has been proposed as a biomarker, but provides only limited insight in the pathophysiol-ogy of muscle function. This work proposes and...

conference paper 2019

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Deficits in tapping accuracy and variability in tremor patients

Luft, Frauke (author), Sharifi, Sarvi (author), Mugge, W. (author), Schouten, A.C. (author), Bour, Lo J. (author), Van Rootselaar, Anne Fleur (author), Veltink, Peter H. (author), Heida, Tijtske (author)

Background: The basal ganglia and cerebellum are brain structures involved in movement initiation, execution and termination. They are thought to be involved in the tremor generation and movement deficits in Parkinson's disease (PD) and essential tremor (ET). Especially in PD, maintaining cyclic movement, such as walking or tapping can be...

journal article 2019

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A Power Spectral Density-Based Method to Detect Tremor and Tremor Intermittency in Movement Disorders

Luft, Frauke (author), Sharifi, Sarvi (author), Mugge, W. (author), Schouten, A.C. (author), Bour, Lo J. (author), van Rootselaar, Anne Fleur (author), Veltink, Peter H. (author), Heida, Tijtske (author)

There is no objective gold standard to detect tremors. This concerns not only the choice of the algorithm and sensors, but methods are often designed to detect tremors in one specific group of patients during the performance of a specific task. Therefore, the aim of this study is twofold. First, an objective quantitative method to detect...

journal article 2019

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Revealing time-varying joint impedance with kernel-based regression and nonparametric decomposition

van de Ruit, M.L. (author), Cavallo, Gaia (author), Lataire, John (author), van der Helm, F.C.T. (author), Mugge, W. (author), van Wingerden, J.W. (author), Schouten, A.C. (author)

During movements, humans continuously regulate their joint impedance to minimize control effort and optimize performance. Joint impedance describes the relationship between a joint's position and torque acting around the joint. Joint impedance varies with joint angle and muscle activation and differs from trial-to-trial due to inherent...

journal article 2018

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Adaptation rate in joint dynamics depends on the time-varying properties of the environment

van de Ruit, M.L. (author), Lataire, John (author), van der Helm, F.C.T. (author), Mugge, W. (author), Schouten, A.C. (author)

During movement, our central nervous system (CNS) takes into account the dynamics of our environment to optimally adapt our joint dynamics. In this study we explored the adaptation of shoulder joint dynamics when a participant interacted with a time-varying virtual environment created by a haptic manipulator. Participants performed a position...

conference paper 2018

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Closed-loop identification to unravel the way the human nervous system controls bodily functions

Schouten, A.C. (author), Mugge, W. (author)

The central nervous system controls body functions and initiates actions through an integrated system of multiple feedback loops. System identification can be a valuable tool to assess the system dynamics. The challenge is to assess the functioning of an intact feedback system in vivo, where cause and effect are intermingled. In this paper we...

conference paper 2018

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Reflex mechanisms in CRPS-related dystonia

Mugge, W. (author), van Hilten, Jacobus J. (author), van der Helm, F.C.T. (author), Schouten, A.C. (author)

This paper focuses on the pathophysiology of fixed dystonia (i.e., sustained muscle contractions resulting in abnormal postures) in Complex Regional Pain Syndrome from an engineering point of view. Although the mechanisms are still elusive, the evidence implicating involvement of aberrant muscle force feedback is compelling. A neuromuscular...

conference paper 2018

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Integration of Sensory Force Feedback Is Disturbed in CRPS-Related Dystonia

Mugge, W. (author), Van der Helm, F.C.T. (author), Schouten, A.C. (author)

Complex regional pain syndrome (CRPS) is characterized by pain and disturbed blood flow, temperature regulation and motor control. Approximately 25% of cases develop fixed dystonia. The origin of this movement disorder is poorly understood, although recent insights suggest involvement of disturbed force feedback. Assessment of sensorimotor...

journal article 2013

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Fixed Dystonia in Complex Regional Pain Syndrome: A Descriptive and Computational Modeling Approach

Munts, A.G. (author), Mugge, W. (author), Meurs, T.S. (author), Schouten, A.C. (author), Marinus, J. (author), Lorimer Moseley, G. (author), Van der Helm, F.C.T. (author), Van Hilten, J.J. (author)

Background: Complex regional pain syndrome (CRPS) may occur after trauma, usually to one limb, and is characterized by pain and disturbed blood flow, temperature regulation and motor control. Approximately 25% of cases develop fixed dystonia. Involvement of dysfunctional GABAergic interneurons has been suggested, however the mechanisms that...

journal article 2011

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A rigorous model of reflex function indicates that position and force feedback are flexibly tuned to position and force tasks

Mugge, W. (author), Abbink, D.A. (author), Schouten, A.C. (author), Dewald, J.P.A. (author), Van der Helm, F.C.T. (author)

This study aims to quantify the separate contributions of muscle force feedback, muscle spindle activity and co-contraction to the performance of voluntary tasks (‘‘reduce the influence of perturbations on maintained force or position’’). Most human motion control studies either isolate only one contributor, or assume that relevant reflexive...

journal article 2009