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Langeveld, Simone A.G. (author), Meijlink, Bram (author), Beekers, Inés (author), Olthof, Mark (author), van der Steen, A.F.W. (author), de Jong, N. (author), Kooiman, Klazina (author)Phospholipid-coated targeted microbubbles are used for ultrasound molecular imaging and locally enhanced drug delivery, with the binding efficacy being an important trait. The use of organic solvent in microbubble production makes the difference between a heterogeneous or homogeneous ligand distribution. This study demonstrates the effect of...journal article 2022
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Lattwein, K.R. (author), Beekers, Inés (author), Kouijzer, Joop J.P. (author), Leon-Grooters, Mariël (author), Langeveld, Simone A.G. (author), van Rooij, Tom (author), van der Steen, A.F.W. (author), de Jong, N. (author), van Wamel, Willem J.B. (author), Kooiman, Klazina (author)Bacteria encased in a biofilm poses significant challenges to successful treatment, since both the immune system and antibiotics are ineffective. Sonobactericide, which uses ultrasound and microbubbles, is a potential new strategy for increasing antimicrobial effectiveness or directly killing bacteria. Several studies suggest that...journal article 2022
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Internalization of targeted microbubbles by endothelial cells and drug delivery by pores and tunnelsBeekers, Inés (author), Langeveld, Simone A.G. (author), Meijlink, Bram (author), van der Steen, A.F.W. (author), de Jong, N. (author), Verweij, M.D. (author), Kooiman, Klazina (author)Ultrasound insonification of microbubbles can locally enhance drug delivery by increasing the cell membrane permeability. To aid development of a safe and effective therapeutic microbubble, more insight into the microbubble-cell interaction is needed. In this in vitro study we aimed to investigate the initial 3D morphology of the endothelial...journal article 2022
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Langeveld, Simone A.G. (author), Beekers, Inés (author), Collado Lara, G. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Kooiman, Klazina (author)Phospholipid-coated microbubbles are ultrasound contrast agents that can be employed for ultrasound molecular imaging and drug delivery. For safe and effective implementation, microbubbles must respond uniformly and predictably to ultrasound. Therefore, we investigated how lipid handling and phase distribution affected the variability in the...journal article 2021