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Starmans, Martijn P.A. (author), Timbergen, Milea J.M. (author), Vos, Melissa (author), Renckens, Michel (author), Grünhagen, Dirk J. (author), van Leenders, Geert J.L.H. (author), Niessen, W.J. (author), Visser, Jacob J. (author), Klein, Stefan (author)Treatment planning of gastrointestinal stromal tumors (GISTs) includes distinguishing GISTs from other intra-abdominal tumors and GISTs’ molecular analysis. The aim of this study was to evaluate radiomics for distinguishing GISTs from other intra-abdominal tumors, and in GISTs, predict the c-KIT, PDGFRA, BRAF mutational status, and mitotic...journal article 2022
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Angus, Lindsay (author), Starmans, M.P.A. (author), Rajicic, Ana (author), Odink, Arlette E. (author), Jalving, Mathilde (author), Niessen, W.J. (author), Visser, Jacob J. (author), Sleijfer, Stefan (author), Klein, Stefan (author), van der Veldt, Astrid A.M. (author)Patients with BRAF mutated (BRAF-mt) metastatic melanoma benefit significantly from treatment with BRAF inhibitors. Currently, the BRAF status is determined on archival tumor tissue or on fresh tumor tissue from an invasive biopsy. The aim of this study was to evaluate whether radiomics can predict the BRAF status in a non-invasive manner....journal article 2021
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Timbergen, Milea J.M. (author), Starmans, Martijn P.A. (author), Padmos, Guillaume A. (author), Grünhagen, Dirk J. (author), van Leenders, Geert J.L.H. (author), Hanff, D. F. (author), Niessen, W.J. (author), Klein, S. (author), Visser, J.J. (author)Purpose: Diagnosing desmoid-type fibromatosis (DTF) requires an invasive tissue biopsy with β-catenin staining and CTNNB1 mutational analysis, and is challenging due to its rarity. The aim of this study was to evaluate radiomics for distinguishing DTF from soft tissue sarcomas (STS), and in DTF, for predicting the CTNNB1 mutation types....journal article 2020