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Van der Stok, J. (author), Wang, H. (author), Yavari, S.A. (author), Siebelt, M. (author), Sandker, M. (author), Waarsing, J.H. (author), Verhaar, J.A.N. (author), Jahr, H. (author), Zadpoor, A.A. (author), Leeuwenburgh, S.C.G. (author), Weinans, H. (author)Porous titanium scaffolds are a promising class of biomaterials for grafting large bone defects, because titanium provides sufficient mechanical support, whereas its porous structure allows bone ingrowth resulting in good osseointegration. To reinforce porous titanium scaffolds with biological cues that enhance and continue bone regeneration,...journal article 2013
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Zadpoor, A.A. (author)The relationship between hip deformities and osteoarthritis has recently received a lot of attention. In particular, it has been shown that both osteoarthritis and its precursors, such as the hip deformities that lead to femoroacetabular impingement (FAI), are more prevalent in elite athletes compared with the general population. However, the...journal article 2015
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Janbaz, S. (author), Weinans, H. (author), Zadpoor, A.A. (author)Recent research has shown the potential of rationally designed geometrical features for controlling the functionality of advanced materials. Of particular recent interest has been the use of geometry for controlling the buckling behaviour of soft materials under compression. However, the effects of geometry may be mixed with those of the...journal article 2016
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Van der Stok, J. (author), Koolen, M.K.E. (author), De Maat, M.P.M. (author), Amin Yavari, S. (author), Alblas, J. (author), Patka, P. (author), Verhaar, J.A.N. (author), Van Lieshout, E.E.M. (author), Zadpoor, A.A. (author), Weinans, H.H. (author), Jahr, H. (author)Regeneration of load-bearing segmental bone defects is a major challenge in trauma and orthopaedic surgery. The ideal bone graft substitute is a biomaterial that provides immediate mechanical stability, while stimulating bone regeneration to completely bridge defects over a short period. Therefore, selective laser melted porous titanium,...journal article 2015
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Zadpoor, A.A. (author), Sinke, J. (author), Benedictus, R. (author)This article studies the properties of a wide range of friction-stir-welded joints with dissimilar aluminum alloys or thicknesses. Two aluminum alloys, namely, 2024-T3 and 7075-T6, are selected for the study and are welded in ten different combinations of alloys and thicknesses. The welding parameters are optimized for each configuration, and a...journal article 2010
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Ahmadi, S.M. (author), Yavari, S.A. (author), Wauthle, R. (author), Pouran, B. (author), Schrooten, J. (author), Weinans, H. (author), Zadpoor, A.A. (author)It is known that the mechanical properties of bone-mimicking porous biomaterials are a function of the morphological properties of the porous structure, including the configuration and size of the repeating unit cell from which they are made. However, the literature on this topic is limited, primarily because of the challenge in fabricating...journal article 2015
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Zadpoor, A.A. (author)Amir A. Zadpoor discusses how the field of biomaterials has changed since the turn of the century.journal article 2013
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Sarkalkan, N. (author), Loeve, A.J. (author), Van Dongen, K.W.A. (author), Tuijthof, G.J.M. (author), Zadpoor, A.A. (author)(Osteo)chondral defects (OCDs) in the ankle are currently diagnosed with modalities that are not convenient to use in long-term follow-ups. Ultrasound (US) imaging, which is a cost-effective and non-invasive alternative, has limited ability to discriminate OCDs. We aim to develop a new diagnostic technique based on US wave propagation through...journal article 2015
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Bsat, S. (author), Yavari, S. (author), Munsch, M. (author), Valstar, E.R. (author), Zadpoor, A.A. (author)Advanced additive manufacturing techniques such as electron beam melting (EBM), can produce highly porous structures that resemble the mechanical properties and structure of native bone. However, for orthopaedic applications, such as joint prostheses or bone substitution, the surface must also be bio-functionalized to promote bone growth. In the...journal article 2015
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Zadpoor, A.A. (author)Investigation of the mechanical behavior of biological tissues and biomaterials has been an active area of research for several decades. However, in recent years, the enthusiasm in understanding the mechanical behavior of biological tissues and biomaterials has increased significantly due to the development of novel biomaterials for new fields...journal article 2015
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Dimaraki, A. (author), Diaz Payno, P.J. (author), Minneboo, M.B. (author), Nouri Goushki, M. (author), Hosseini, M. (author), Kops, N. (author), Narcisi, R. (author), Mirzaali, Mohammad J. (author), van Osch, G.J.V.M. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)The treatment of articular cartilage defects remains a significant clinical challenge. This is partially due to current tissue engineering strategies failing to recapitulate native organization. Articular cartilage is a graded tissue with three layers exhibiting different cell densities: the superficial zone having the highest density and the...journal article 2021
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van Manen, T. (author), Janbaz, S. (author), Jansen, K.M.B. (author), Zadpoor, A.A. (author)Shape-shifting materials are a powerful tool for the fabrication of reconfigurable materials. Upon activation, not only a change in their shape but also a large shift in their material properties can be realized. As compared with the 4D printing of 2D-to-3D shape-shifting materials, the 4D printing of reconfigurable (i.e., 3D-to-3D shape...journal article 2021
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Zadpoor, A.A. (author)Meta-biomaterials are designer biomaterials with unusual and even unprecedented properties that primarily originate from their geometrical designs at different (usually smaller) length scales. This concept has been primarily used in the context of orthopedic biomaterials with the ultimate aim of improving the bone tissue regeneration performance...journal article 2020
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Putra, N.E. (author), Leeflang, M.A. (author), Ducret, Verena (author), Patrulea, Viorica (author), Fratila-Apachitei, E.L. (author), Perron, Karl (author), Ye, Hua (author), Zhou, J. (author), Apachitei, I. (author), Zadpoor, A.A. (author)Implant-associated infections are highly challenging to treat, particularly with the emergence of multidrug-resistant microbials. Effective preventive action is desired to be at the implant site. Surface biofunctionalization of implants through Ag-doping has demonstrated potent antibacterial results. However, it may adversely affect bone...journal article 2022
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Naghavi Zadeh, S.M. (author), Alijani, F. (author), Chen, X. (author), Dayyani, Iman (author), Yasaee, Mehdi (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)Mechanical metamaterials are advanced engineering materials that exhibit unusual properties that cannot be found in nature. The elastic properties (i.e., elastic modulus and Poisson's ratio) of mechanical metamaterials can be tuned by changing the geometry of their fundamental unit cells. This allows for the design of metamaterial lattices...journal article 2021
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Gijsen, F.J.H. (author), Vis, Bas (author), Barrett, Hilary E. (author), Zadpoor, A.A. (author), Verhagen, Hence J. (author), Bos, Daniel (author), van der Steen, A.F.W. (author), Akyildiz, A.C. (author)Objective: Atherosclerotic plaque rupture in carotid arteries is a major source of cerebrovascular events. Calcifications are highly prevalent in carotid plaques, but their role in plaque rupture remains poorly understood. This work studied the morphometric features of calcifications in carotid plaques and their effect on the stress...journal article 2021
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Janbaz, S. (author), Hedayati, R. (author), Zadpoor, A.A. (author)Nature uses various activation mechanisms to program complex transformations in the shape and functionality of living organisms. Inspired by such natural events, we aimed to develop initially flat (i.e. two-dimensional) programmable materials that, when triggered by a stimulus such as temperature, could self-transform their shape into a complex...journal article 2016
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Bobbert, F.S.L. (author), Lietaert, K. (author), Eftekhari, A.A. (author), Pouran, B. (author), Ahmadi, S.M. (author), Weinans, Harrie (author), Zadpoor, A.A. (author)Porous biomaterials that simultaneously mimic the topological, mechanical, and mass transport properties of bone are in great demand but are rarely found in the literature. In this study, we rationally designed and additively manufactured (AM) porous metallic biomaterials based on four different types of triply periodic minimal surfaces (TPMS)...journal article 2017
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Bobbert, F.S.L. (author), Zadpoor, A.A. (author)The success of bone substitutes used to repair bone defects such as critical sized defects depends on the architecture of the porous biomaterial. The architectural parameters and surface properties affect cell seeding efficiency, cell response, angiogenesis, and eventually bone formation. The relevant parameters include pore size and porosity,...journal article 2017
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Kolken, H.M.A. (author), Zadpoor, A.A. (author)The surge of interest in so-called "designer materials" during the last few years together with recent advances in additive manufacturing (3D printing) techniques that enable fabrication of materials with arbitrarily complex nano/micro-architecture have attracted increasing attention to the concept of mechanical metamaterials. Owing to their...journal article 2017