Agent-based mathematical modeling of pancreatic cancer growth and several therapies

Cancer is known as one of the leading causes of death in the world with difficult<br/>diagnose at early stages, poor prognosis and high mortality. Animal-based<br/>experiments and clinical trials have always been the main approach for cancer<br/>research, albeit they may have limitations and ethical issues. Mathematicalmodeling<br/>as an...

A Cellular Automata Model of Oncolytic Virotherapy in Pancreatic Cancer

Oncolytic virotherapy is known as a new treatment to employ less virulent viruses to specifically target and damage cancer cells. This work presents a cellular automata model of oncolytic virotherapy with an application to pancreatic cancer. The fundamental biomedical processes (like cell proliferation, mutation, apoptosis) are modeled by the...

Computational modeling of therapy on pancreatic cancer in its early stages

More than eighty percent of pancreatic cancer involves ductal adenocarcinoma with an abundant desmoplastic extracellular matrix surrounding the solid tumor entity. This aberrant tumor microenvironment facilitates a strong resistance of pancreatic cancer to medication. Although various therapeutic strategies have been reported to be effective...

A phenomenological model for cell and nucleus deformation during cancer metastasis

Cell migration plays an essential role in cancer metastasis. In cancer invasion through confined spaces, cells must undergo extensive deformation, which is a capability related to their metastatic potentials. Here, we simulate the deformation of the cell and nucleus during invasion through a dense, physiological microenvironment by developing...