- document
-
Marsden, S.R. (author), Mestrom, L. (author), McMillan, D.G.G. (author), Hanefeld, U. (author)The enzymatic synthesis of esters and peptides is unfavoured in aqueous solvent systems due to competing hydrolysis. This can be overcome by using energy rich substrate analogues: elimination of a good leaving group temporarily establishes more favourable equilibrium conditions, allowing for (nearly) complete conversion. While kinetically...review 2019