Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence

In prostate cancer, androgen receptor (AR)–targeting agents are very effective in various disease stages. However, therapy resistance inevitably occurs, and little is known about how tumor cells adapt to bypass AR suppression. Here, we performed integrative multiomics analyses on tissues isolated before and after 3 months of AR-targeting...

Contextual Multidimensional Relevance Models

Information retrieval systems centrally build upon the concept of relevance in order to rank documents in response to a user's query. Assessing relevance is a non-trivial operation that can be influenced by a multitude of factors that go beyond mere topical overlap with the query. This thesis argues that relevance depends on personal (Chapter 2)...

Increasing cheat robustness of crowdsourcing tasks

Crowdsourcing successfully strives to become a widely used means of collecting large-scale scientific corpora. Many research fields, including Information Retrieval, rely on this novel way of data acquisition. However, it seems to be undermined by a significant share of workers that are primarily interested in producing quick generic answers...