Optimization-based adaptive optics for optical coherence tomography

Optical coherence tomography (OCT) is a technique for non-invasive imaging based on low coherence interferometry. Its main application is found in ophthalmology, where it is used for 3D in vivo imaging of the cornea and the retina. OCT has evolved over the past decade as one of the most important ancillary tests in ophthalmic practice, providing...

Wavefront control with a multi-actuator adaptive Lens in imaging applications

The use of adaptive lenses instead of deformable mirrors can simplify the implementation of an adaptive optics system. The recently introduced Multi-actuator Adaptive Lens (MAL) can be used in closed loop with a wavefront sensor to correct for time-variant wavefront aberrations. The MAL can guarantee a level of correction and a response time...

Adaptive optics for confocal laser scanning microscopy with adjustable pinhole

The pinhole plays an important role in confocal laser scanning microscopy (CLSM) for adaptive optics (AO) as well as in imaging, where the size of the pinhole denotes a trade-off between out-of-focus rejection and wavefront distortion. This contribution proposes an AO system for a commercial CLSM with an adjustable square pinhole to cope with...

Optomechatronics Design and Control for Confocal Laser Scanning Microscopy

Confocal laser scanning microscopy (CLSM) is considered as one of the major advancements in microscopy in the last century and is widely accepted as a 3D fluorescence imaging tool for biological studies. For the emerging biological questions CLSM requires fast imaging to detect rapid biological processes and aberration-corrected imaging to...

Adaptive Optics based on Liquid Total Internal Re?ection Mirrors

This thesis investigates a novel deformable mirror that works on the basis of the electrostatic deformation of a liquid surface. The liquid mirror allows large surface displacements, a large number of actuators, and the modification of its properties, while at the same time the mirror design is simple and may be realized without sophisticated...