Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

Cortical thickness, surface area and volumes (MRI cortical measures) vary with age and cognitive function, and in neurological and psychiatric diseases. We examined heritability, genetic correlations and genome-wide associations of cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample...

Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824...

Analyzing airport security checkpoint performance using cognitive agent models

Modern airports operate under high demands and pressures, and strive to satisfy many diverse, interrelated, sometimes conflicting performance goals. Airport performance areas, such as security, safety, and efficiency are usually studied separately from each other. However, operational decisions made by airport managers often impact several...

Genetic variation underlying cognition and its relation with neurological outcomes and brain imaging

Cognition in adults shows variation due to developmental and degenerative components. A recent genomewide association study identified genetic variants for general cognitive function in 148 independent loci. Here, we aimed to elucidate possible developmental and neurodegenerative pathways underlying these genetic variants by relating them to...

A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

Brain lobar volumes are heritable but genetic studies are limited. We performed genome-wide association studies of frontal, occipital, parietal and temporal lobe volumes in 16,016 individuals, and replicated our findings in 8,789 individuals. We identified six genetic loci associated with specific lobar volumes independent of intracranial...

AATOM - An Agent-based Airport Terminal Operations Model

In this work, AATOM, a microscopic agent-based model that simulates movement and operations in the airport terminal is presented. Specifcally, the model includes the main handling processes required for outbound passengers namely, check-in, security and border control. Furthermore, basic facilities for discretionary activities are modelled...

A semi-analytical thermal modelling approach for selective laser melting

Selective laser melting (SLM) wherein a metal part is built in a layer-by-layer manner in a powder bed is a promising and versatile way for manufacturing components with complex geometry. However, components built by SLM suffer from substantial deformation of the part and residual stresses. Residual stresses arise due to temperature gradients...

The cultivation of information infrastructures for international trade: Stakeholder challenges and engagement reasons

The development of information infrastructures for international trade to improve supply chain visibility and security has gained momentum due to technological advances. An information infrastructure is a shared, open, and evolving assemblage of interlinked information systems providing distinct information technology capabilities. Examples...

Conversion of organic micropollutants with limited bromate formation during the Peroxone process in drinking water treatment

Advanced oxidation with O3 / H2O2 (peroxone) was conducted on pilot plant scale on pre-treated Meuse river water to investigate the conversion of organic micropollutants (OMPs) and the formation of bromate. Fourteen selected model compounds were dosed to the pre-treated river water on a regular basis to assess the efficiency of the peroxone...

Natural manganese deposits as catalyst for decomposing hydrogen peroxide

Drinking water companies (are intending to) implement advanced oxidation processes (AOP) in their treatment schemes to increase the barrier against organic micropollutants (OMPs). It is necessary to decompose the excessive hydrogen peroxide after applying AOP to avoid negative effects in the following, often biological, treatment steps. A...

Natural manganese deposits as catalyst for decomposing hydrogen peroxide (discussion paper)

Drinking water companies more and more implement Advanced Oxidation Processes (AOP) in their treatment schemes to increase the barrier against organic micropollutants (OMPs). It is necessary to decompose the excessive hydrogen peroxide after applying AOP to avoid negative effects in the following, often biological, treatment steps. A drinking...

Governing Logistics Information Platforms

The Extended Single Window (ESW) project aims to support goods flows by Information and Communication Technology (ICT). Specifically, the project takes the concept of Single Windows (often used in the sense that governments offer a single portal or interface to which businesses can submit information, supporting re-ruse by multiple agencies and...

Kinetica: A playful way through the world of moving facades

This "designers' manual" is made during the TIDO-course AR0531 Innovation and Sustainability This manual takes you through a series of buildings based on their kinetic facade system. To be able to show you how these systems work they are divided into five types: folding facades, sliding facades, layered facades, turning facades and the so called...