Varela, I. (author), Klijn, C.N. (author), Stephens, P.J. (author), Mudie, L.J. (author), Stebbings, L. (author), Galappaththige, D. (author), Van der Gulden, H. (author), Schut, E. (author), Klarenbeek, S. (author), Campbell, P.J. (author), Wessels, L.F.A. (author), Stratton, M.R. (author), Jonkers, J. (author), Futreal, P.A. (author), Adams, D.J. (author) Background: Here we present the first paired-end sequencing of tumors from genetically engineered mouse models of cancer to determine how faithfully these models recapitulate the landscape of somatic rearrangements found in human tumors. These were models of Trp53-mutated breast cancer, Brca1- and Brca2-associated hereditary breast cancer, and E...
journal article 2010
