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Kok, R.N.U. (author)How does the small intestine maintain itself? What mechanism does it use to achieve<br/>homeostasis, and how optimal is this mechanism? We approached these questions<br/>mainly using cell tracking in organoids, for which we developed new cell trackers.<br/>We found that the intestinal crypt uses a surprisingly simple and effective strategy.<br/...doctoral thesis 2024
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Xu, J. (author), Vecstaudza, Jana (author), Wesdorp, Marinus A. (author), Labberté, Margot (author), Salerno, Manuela (author), Kok, Joeri (author), van Rietbergen, Bert (author), van Osch, G.J.V.M. (author), Locs, Janis (author), Brama, Pieter A.J. (author)Osteochondral defect repair with a collagen/collagen-magnesium-hydroxyapatite (Col/Col-Mg-HAp) scaffold has demonstrated good clinical results. However, subchondral bone repair remained suboptimal, potentially leading to damage to the regenerated overlying neocartilage. This study aimed to improve the bone repair potential of this scaffold by...journal article 2024
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den Heijer, F. (author), Kok, M. (author)A system of dikes in flood-prone areas continuously requires measures to mitigate changes such as ageing and climate change. Planning costly measures requires proper insight into system risk effects. Especially in a riverine dike system, the risk contributions of individual assets to the system flood risks are not independent, because...journal article 2023
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Hobeika, N. (author), van Rijssel, L.N. (author), Prusti, M.K. (author), Dinklo, C.J.T. (author), Giannelli, D. (author), Dukai, B. (author), Kok, Arnaud (author), van Loon, Rob (author), Nota, René (author), Stoter, J.E. (author)Noise simulations are an important part of noise studies that investigate the impact of noise sources on the environment. In noise simulation, noise levels at receiver points are calculated based on the noise propagation paths between the receiver and source points. These paths are derived from the height of the terrain. In current calculation...journal article 2023
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Kok, Sjaak (author), Amoozandeh, A. (author), Radaelli, G. (author)Elastic structures that can deflect without springback, known as neutrally stable structures, form a remarkable group within their field, since they require the energetic state to remain unchanged during elastic deformation. Several examples in the literature obtain this state of neutral stability by the application of pre-stress, either as a...journal article 2023
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Xu, J. (author), Fahmy-Garcia, Shorouk (author), Wesdorp, Marinus A. (author), Forte, Lucia (author), De Luca, Claudio (author), Filardo, Giuseppe (author), Labberté, Margot (author), Kok, Joeri (author), Nickel, Joachim (author), van Osch, G.J.V.M. (author)Despite promising clinical results in osteochondral defect repair, a recently developed bi-layered collagen/collagen-magnesium-hydroxyapatite scaffold has demonstrated less optimal subchondral bone repair. This study aimed to improve the bone repair potential of this scaffold by adsorbing bone morphogenetic protein 2 (BMP-2) and/or platelet...journal article 2023
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Kok, M. (author), Slager, Kymo (author), de Moel, Hans (author), Botzen, Wouter (author), de Bruijn, Karin (author), Wagenaar, Dennis (author), Rikkert, S.J.H. (author), Koks, Elco (author), van Ginkel, Kees (author)The floods in the Netherlands in the summer of 2021 led to severe economic damage and losses in the affected area. A first estimate in September 2021 showed that more than 2,500 houses, more than 5,000 inhabitants and around 600 businesses were affected. Using the Dutch standard Flood Damage and Loss Model (SSM2017), and based on figures from...journal article 2023
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Klerk, W.J. (author), van Bergeijk, Vera (author), Kanning, W. (author), Wolfert, A.R.M. (author), Kok, M. (author)The condition of flood defence revetments is influenced by many different degradation processes such as animal burrowing, rutting and growth of weeds. Many of these processes are shock-based rather than progressive continuous. As shocks can cause a drop in performance, this means that the condition of a revetment can suddenly decrease,...journal article 2023
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van der Holst, Bart (author), Verhoeven, Gijs (author), Matthijssen, E.F. (author), Vrijlandt, Mark (author), van der Meer, A.A. (author), Plug, R.B.F. (author), Kok, Koen (author)Due to the increasing penetration of distributed energy resources, congestion problems are already emerging in Dutch distribution grids. The available flexibility of assets in the built environment could have the potential to reduce congestion if prosumers are properly incentivized by distribution grid operators (DSOs). However, it is not yet...conference paper 2023
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Eichengreen, Adva (author), Tsou, Yung Ting (author), Nasri, Maedeh (author), van Klaveren, Lisa Maria (author), Li, Boya (author), Koutamanis, A. (author), Baratchi, Mitra (author), Blijd-Hoogewys, Els (author), Kok, Joost (author), Rieffe, Carolien (author)Social connectedness at school is crucial to children's development, yet very little is known about the way it has been affected by school closures during COVID-19 pandemic. We compared pre-post lockdown levels of social connectedness at a school playground in forty-three primary school-aged children, using wearable sensors, observations,...journal article 2023
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van der Voorn, Tom (author), Quist, J.N. (author), Svenfelt, Åsa (author), Kok, Kasper (author), Hickman, Robin (author), Sheppard, Stephen (author), Kanyama, Annika Carlsson (author), Banister, David (author)In the face of climate change, a major challenge is to inform and guide long-term climate change adaptation planning under deep uncertainty, while aiming at transformative change. Normative futures studies approaches, such as participatory backcasting, visioning and transition management, are increasingly applied, but their potential for climate...journal article 2023
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- Iglesias van Montfort, H.P. (author), Subramanian, S.S. (author), Irtem, I.E. (author), Sassenburg, M. (author), Li, Mengran (author), Kok, J.J. (author), Middelkoop, J. (author), Burdyny, T.E. (author) journal article 2023
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Viset, F.M. (author), Helmons, R.L.J. (author), Kok, M. (author)Accurately estimating the positions of multi-agent systems in indoor environments is challenging due to the lack of Global Navigation Satelite System (GNSS) signals. Noisy measurements of position and orientation can cause the integrated position estimate to drift without bound. Previous research has proposed using magnetic field simultaneous...conference paper 2023
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Edridge, T.I. (author), Kok, M. (author)Ferromagnetic materials in indoor environments give rise to disturbances in the ambient magnetic field. Maps of these magnetic disturbances can be used for indoor localisation. A Gaussian process can be used to learn the spatially varying magnitude of the magnetic field using magnetometer measurements and information about the position of the...conference paper 2023
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Menzen, C.M. (author), Fetter, Marnix (author), Kok, M. (author)We present a mapping algorithm to compute large-scale magnetic field maps in indoor environments with approximate Gaussian process (GP) regression. Mapping the spatial variations in the ambient magnetic field can be used for 10-calization algorithms in indoor areas. To compute such a map, GP regression is a suitable tool because it provides...conference paper 2023
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Skog, Isaac (author), Hendeby, Gustaf (author), Kok, M. (author)A framework for tightly integrated motion mode classification and state estimation in motion-constrained inertial navigation systems is presented. The framework uses a jump Markov model to describe the navigation system's motion mode and navigation state dynamics with a single model. A bank of Kalman filters is then used for joint inference...conference paper 2023
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van der Stel, Stefan D. (author), Lai, Marco (author), Groen, Harald C. (author), Witteveen, Mark (author), Kuhlmann, Koert F.D. (author), Grotenhuis, Brechtje A. (author), Kok, Niels F.M. (author), van Gastel, Mark (author), Hendriks, B.H.W. (author), Ruers, Theo J.M. (author)Introduction: Anastomotic leakage after gastrointestinal surgery has a high impact on patient's quality of life and its origin is associated with inadequate perfusion. Imaging photoplethysmography (iPPG) is a noninvasive imaging technique that measures blood-volume changes in the microvascular tissue bed and detects changes in tissue...journal article 2023
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Bennis, N.X. (author), Anderson, Jonah P. (author), Kok, Siebe M.C. (author), Daran, J.G. (author)ErCas12a is a class 2 type V CRISPR-Cas nuclease isolated from Eubacterium rectale with attractive fundamental characteristics, such as RNA self-processing capability, and lacks reach-through royalties typical for Cas nucleases. This study aims to develop a ErCas12a-mediated genome editing tool applicable in the model yeast Saccharomyces...journal article 2023
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Chiasson, David (author), Lin, Yuan (author), Kok, M. (author), Shull, Peter (author)Hyperbolic localization measures the time difference of arrivals (TDOAs) of signals to determine the location of a wireless source or receiver. Traditional methods depend on precise clock synchronization between nodes so that time measurements from independent devices can be meaningfully compared. Imperfect synchronization is often the dominant...journal article 2023
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Endendijk, Thijs (author), Botzen, W. J. Wouter (author), de Moel, Hans (author), Aerts, Jeroen C. J. H. (author), Slager, Kymo (author), Kok, M. (author)Flood events are expected to increase in their frequency and severity, which results in higher flood risk without additional adaptation measures. The information gained from flood risk models is essential in effective disaster risk management. However, vulnerability estimations are often a large driver of uncertainty, and flood damage is...journal article 2023