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Azevedo Vasconcelos, A.C. (author), Heijnen, S. (author), Holtzer, Bart (author), Aragon, A.M. (author), Schott, D.L. (author), Jovanova, J. (author)The performance improvement of renewable energy sources has become nowadays a crucial topic to boost the energy transition. With respect to offshore wind farms, larger wind turbines are currently being designed to increase their power capacity. To support such turbines into the seabed, monopile foundations are mainly used, due to their low-cost...conference paper 2023
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Langeveld, J.G. (author), Schilperoort, Remy (author), Heijnen, Leo (author), Elsinga, Goffe (author), Schapendonk, Claudia E.M. (author), Fanoy, Ewout (author), de Schepper, Evelien I.T. (author), Koopmans, Marion P.G. (author), de Graaf, Miranda (author), Medema, G.J. (author)Over the course of the Corona Virus Disease-19 (COVID-19) pandemic in 2020–2022, monitoring of the severe acute respiratory syndrome coronavirus 2 ribonucleic acid (SARS-CoV-2 RNA) in wastewater has rapidly evolved into a supplementary surveillance instrument for public health. Short term trends (2 weeks) are used as a basis for policy and...journal article 2023
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Wang, N. (author), Verzijlbergh, R.A. (author), Heijnen, P.W. (author), Herder, P.M. (author)Energy system optimization models are widely used to aid long-term investment decision-making for energy systems. From a socio-technical system viewpoint, existing models focus on the cost modeling of the technical subsystem, while the indirect costs of the social subsystem are not often modeled. This paper incorporates indirect costs into such...journal article 2023
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de Graaf, Miranda (author), Langeveld, J.G. (author), Post, Johan (author), Carrizosa, Christian (author), Franz, Eelco (author), Izquierdo-Lara, Ray W. (author), Elsinga, Goffe (author), Heijnen, Leo (author), Medema, G.J. (author)Despite high vaccination rates in the Netherlands, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to circulate. Longitudinal sewage surveillance was implemented along with the notification of cases as two parts of the surveillance pyramid to validate the use of sewage for surveillance, as an early warning tool, and to...journal article 2023
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Izquierdo-Lara, Ray W. (author), Heijnen, Leo (author), Oude Munnink, Bas B. (author), Schapendonk, Claudia M.E. (author), Elsinga, Goffe (author), Langeveld, J.G. (author), Post, Johan (author), Prasad, Divyae K. (author), Medema, G.J. (author)Monitoring of SARS-CoV-2 in wastewater (WW) is a promising tool for epidemiological surveillance, correlating not only viral RNA levels with the infection dynamics within the population, but also to viral diversity. However, the complex mixture of viral lineages in WW samples makes tracking of specific variants or lineages circulating in the...journal article 2023
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Wang, N. (author), LIU, Z. (author), Heijnen, P.W. (author), Warnier, Martijn (author)As the use of distributed energy resources increases, peer-to-peer (P2P) energy trading is becoming a promising way to harmonize the decarbonization and decentralization transformations in the energy sector. P2P markets give households the autonomy to make individual decisions and thus they may cooperate with each other to obtain economic...journal article 2022
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van Gulik, W.M. (author), Canelas, A (author), Nikerel, I.E. (author), Douma, RD (author), de Jonge, L.P. (author), Heijnen, J.J. (author)Obtaining meaningful snapshots of the metabolome of microorganisms requires rapid sampling and immediate quenching of all metabolic activity, to prevent any changes in metabolite levels after sampling. Furthermore, a suitable extraction method is required ensuring complete extraction of metabolites from the cells and inactivation of enzymatic...book chapter 2022
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Frey, Daniel D. (author), Lin, Yiben (author), Heijnen, P.W. (author)This paper develops theoretical foundations for extending Gauss-Hermite quadrature to robust design with computer experiments. When the proposed method is applied with m noise variables, the method requires 4m + 1 function evaluations. For situations in which the polynomial response is separable, this paper proves that the method gives exact...journal article 2021
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Okur, Ö. (author), Heijnen, P.W. (author), Lukszo, Z. (author)Flexibility coming from consumers in residential and service sectors has received significant attention to deal with uncertainty and variability of renewable energy sources. Since these consumers are too small individually to participate in the electricity markets, their assets can be pooled by an aggregator. The aggregator can implement...review 2021
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Wang, N. (author), Verzijlbergh, R.A. (author), Heijnen, P.W. (author), Herder, P.M. (author)This paper reviews the literature on the modeling approaches on decentralized energy investment and operation in the prosumer era. The study has several contributions. Firstly, it adds investment models into the review which have not been previously reviewed for decentralized energy modeling. Secondly, a modeling framework consisting of four...conference paper 2020
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Okur, Ö. (author), Heijnen, P.W. (author), Lukszo, Z. (author)Aggregators are considered essential to obtain flexibility from small residential and service sector consumers. They can implement business models by trading flexibility from their consumers' assets in various electricity markets. The aim of this paper is to identify challenges faced by aggregators with different roles, while implementing...conference paper 2020
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Wang, N. (author), Heijnen, P.W. (author), Imhof, Pieter (author)Renewable energy investment is a complex process where multiple actors are often involved with their own, sometimes conflicting, interests. Here we propose a multi-actor multi-objective regional energy system planning approach to help actors gain mutual understanding regarding each other’s optimal investment wishes, in order to advance the...journal article 2020
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Wang, N. (author), Verzijlbergh, R.A. (author), Heijnen, P.W. (author), Herder, P.M. (author)Variable Renewable Energy Sources (VRES) are characterized by intensive land-use and variable production. In existing optimization models that minimize the total cost of the energy system, location-specific VRES production profiles are often used to estimate VRES potential, but land-use and land cover aspects have been largely ignored. In this...journal article 2020
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Hornstra, Luc M. (author), Rodrigues da Silva, T. (author), Blankert, Bastiaan (author), Heijnen, Leo (author), Beerendonk, Erwin (author), Cornelissen, Emile R. (author), Medema, G.J. (author)High pressure membranes are increasingly used for the treatment of contaminated water for various purposes including irrigation and drinking water. The lack of a fast and easy to implement membrane integrity test method with a log removal value (LRV) >3 hampers the implementation of these membranes. Current on-line methods include...journal article 2019
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Aggregator-mediated demand response: Minimizing imbalances caused by uncertainty of solar generationOkur, Ö. (author), Voulis, N. (author), Heijnen, P.W. (author), Lukszo, Z. (author)The high level of uncertainty of renewable energy sources generation creates differences between electricity supply and demand, endangering the reliable operation of the power system. Demand response has gained significant attention as a means to cope with uncertainty of renewable energy sources. Demand response of residential and service...journal article 2019
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Heijnen, P.W. (author), Chappin, E.J.L. (author), Herder, P.M. (author)Systems engineers are equipped to design complex networked systems such as infrastructures. A key goal is cost minimization over a vast solution space. However, finding a minimum-cost system while comprehensively satisfying different stakeholders is challenging and lacks proper methodological support. Stakeholders often employ their own...journal article 2019
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Wang, G. (author), Zhao, Junfei (author), Haringa, C. (author), Tang, W. (author), Xia, Jianye (author), Chu, Ju (author), Zhuang, Yingping (author), Zhang, Siliang (author), Deshmukh, A.T. (author), van Gulik, W.M. (author), Heijnen, J.J. (author), Noorman, H.J. (author)In a 54 m<sup>3</sup> large-scale penicillin fermentor, the cells experience substrate gradient cycles at the timescales of global mixing time about 20–40 s. Here, we used an intermittent feeding regime (IFR) and a two-compartment reactor (TCR) to mimic these substrate gradients at laboratory-scale continuous cultures. The IFR was applied to...journal article 2018
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Wang, N. (author), Heijnen, P.W. (author), Verzijlbergh, R.A. (author), Kunneke, R.W. (author), Herder, P.M. (author)Dutch regional municipalities increasingly take an active role in the transition to more sustainable and autonomous energy supply systems, using local energy sources like wind, solar and biomass. The ambition, on the one hand, concerns how an optimal local energy supply system can be designed such that local energy targets can be realized with...abstract 2018
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Haringa, C. (author), Tang, W. (author), Wang, G. (author), Deshmukh, A.T. (author), van Winden, Wouter A. (author), Chu, Ju (author), van Gulik, W.M. (author), Heijnen, J.J. (author), Mudde, R.F. (author), Noorman, H.J. (author)We assess the effect of substrate heterogeneity on the metabolic response of P. chrysogenum in industrial bioreactors via the coupling of a 9-pool metabolic model with Euler-Lagrange CFD simulations. In this work, we outline how this coupled hydrodynamic-metabolic modeling can be utilized in 5 steps. (1) A model response study with a fixed...journal article 2018
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Okur, Ö. (author), Voulis, N. (author), Heijnen, P.W. (author), Lukszo, Z. (author)Aggregators are considered essential to extend demand response (DR) to small residential and service sector consumers. Both sectors currently have untapped load flexibility, which is considered key to support renewable resource integration. Aggregators can offer this flexibility in bulk to other power system parties. This paper addresses the...conference paper 2018