Engineered biochemical cues of regenerative biomaterials to enhance endogenous stem/progenitor cells (ESPCs)-mediated articular cartilage repair

As a highly specialized shock-absorbing connective tissue, articular cartilage (AC) has very limited self-repair capacity after traumatic injuries, posing a heavy socioeconomic burden. Common clinical therapies for small- to medium-size focal AC defects are well-developed endogenous repair and cell-based strategies, including microfracture,...

Groundwater Vulnerability in a Megacity Under Climate and Economic Changes: A Coupled Sociohydrological Analysis

Groundwater depletion has become increasingly challenging, and many cities worldwide have adopted drastic policies to relieve water stress due to socioeconomic growth. Located on the declining aquifer of the North China Plain, Beijing, for example, has developed plans to limit the size of the city’s population. However, the effect of...