snRNA-seq analysis in multinucleated myogenic FSHD cells identifies heterogeneous FSHD transcriptome signatures associated with embryonic-like program activation and oxidative stress-induced apoptosis

The sporadic nature of DUX4 expression in FSHD muscle challenges comparative transcriptome analyses between FSHD and control samples. A variety of DUX4 and FSHD-associated transcriptional changes have been identified, but bulk RNA-seq strategies prohibit comprehensive analysis of their spatiotemporal relation, interdependence and role in the...

The anatomy of the thoracic spinal canal investigated with magnetic resonance imaging (MRI)

Background and Objectives : Anesthesiologists are reluctant to consider higher levels for spinal anesthesia, largely due to direct threats to the spinal cord. The goal of this study is to investigate, with magnetic resonance imaging (MRI), the distances between the relevant structures of the spinal canal (spinal cord, thecal tissue, etc.) to...

Position-controlled epitaxial III-V nanowires on silicon

RIVERSandLAND: Dikes for eternity, an ace up our sleeve

This investigation is aimed at creating an alternative concept of living with water and required flood safety for the large Dutch rivers, which concept can be realised over some hundred of years. It has provided the opportunity for frank and open thinking and discussion, and should lead to a concept that can be also used in other areas. An...

RIVERSandLAND - Dikes for eternity - An ace up our sleeve

The question is often raised as to how long the next generations can continue to live and work in low-Iying Dutch Delta. The system of dikes, combined with the limited space for rivers, should guarantee our safety against inundation for the next hundred years, at least. But what do we do thereafter, wh en the sea level continues to rise,...

Bedrijfsverbetering Zeescheepsreparatie: Gezamenlijke inkoop, wat kunnen we besparen

Technical report erosion resistance of grassland as dike covering

Old dikes are usually still constructed entirely from clay and since 1953 many much heavier dikes have been made from a core of sand with a covering. This construction puts heavier requirements on the covering, as it also does for grassland on a clay layer. These and other developments have led to the need for more insight into the strength of...

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