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Breve, T. (author), Liu, H. (author), Denkova, A.G. (author), Eelkema, R. (author)
Gamma radiation triggered secondary crosslinking of dextran hydrogels leads to macroscopic hydrogel contraction. The authors use stable polymer hydrogels, prepared through azide-alkyne crosslinking, containing surplus alkyne groups. γ-irradiation of these gels leads to more alkyne crosslinking, enabling controlled increase of crosslink...
journal article 2021
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Liu, H. (author), Laan, A.C. (author), Plomp, J. (author), Parnell, S.R. (author), Men, Y. (author), Dalgliesh, Robert M. (author), Eelkema, R. (author), Denkova, A.G. (author)
Polymeric micelles, due to their easy preparation and versatile properties, have been widely applied as one of the most popular carriers for chemotherapeutic agents. Such micelles primarily prevent the leakage of drugs during transportation and thus protect healthy tissue. Controlled drug release, which releases the drugs at the site of...
journal article 2021