Eichenberger, Michael (author), Hüppi, S.N. (author), Patsch, David (author), Aeberli, Natalie (author), Berweger, Raphael (author), Dossenbach, Sandro (author), Eichhorn, Eric (author), Flachsmann, Felix (author), Hortencio, Lucas (author) Squalene–hopene cyclases (SHCs) have great potential for the industrial synthesis of enantiopure cyclic terpenoids. A limitation of SHC catalysis has been the enzymes’ strict (S)-enantioselectivity at the stereocenter formed after the first cyclization step. To gain enantio-complementary access to valuable monocyclic terpenoids, an SHC-wild...
journal article 2021
