Spatial relationships in the urothelial and head and neck tumor microenvironment predict response to combination immune checkpoint inhibitors

Immune checkpoint inhibitors (ICI) can achieve remarkable responses in urothelial cancer (UC), which may depend on tumor microenvironment (TME) characteristics. However, the relationship between the TME, usually characterized by immune cell density, and response to ICI is unclear. Here, we quantify the TME immune cell densities and spatial...

Microbial quality of swimming pool water with treatment without disinfection, with ultrafiltration, with UV-based treatment and with chlorination

Swimming pools are traditionally disinfected with a residual disinfectant such as sodium hypochlorite. Nowadays, swimming water without a residual disinfectant is increasingly popular, as can be seen by the growing number of (natural) swimming ponds (Weilandt 2015), but health risks for bathers do raise concerns for these type of pools, so some...

Microbial quality of swimming pool water: Treatment without disinfection, with ultrafiltration, with UV-based treatment and chlorination (PPT)