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Putra, N.E. (author), Moosabeiki, Vahid (author), Leeflang, M.A. (author), Zhou, J. (author), Zadpoor, A.A. (author)
Additively manufactured (AM) biodegradable porous iron-manganese (FeMn) alloys have recently been developed as promising bone-substituting biomaterials. However, their corrosion fatigue behavior has not yet been studied. Here, we present the first study on the corrosion fatigue behavior of an extrusion-based AM porous Fe35Mn alloy under...
journal article 2024
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Yang, J. (author), Chen, Xiaohong (author), Sun, Yuanxi (author), Feng, Chen (author), Yang, Zheng (author), Zadpoor, A.A. (author), Mirzaali, Mohammad J. (author), Bai, Long (author)
The advent of additive manufacturing has facilitated the design and fabrication of hybrid lattice structures with multiple morphologies. These structures combine multiple distinct architectures into a single structure with an exceptional performance that far exceeds that of each constituting architecture. However, combining strut-based...
journal article 2023
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Li, Yageng (author), Shi, Yixuan (author), Lu, Yuchen (author), Li, Xuan (author), Zhou, J. (author), Zadpoor, A.A. (author), Wang, Luning (author)
With the advancement of additive manufacturing (AM), customized vascular stents can now be fabricated to fit the curvatures and sizes of a narrowed or blocked blood vessel, thereby reducing the possibility of thrombosis and restenosis. More importantly, AM enables the design and fabrication of complex and functional stent unit cells that...
review 2023
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Li, Y. (author), Pavanram, P. (author), Bühring, J. (author), Rütten, S. (author), Schröder, K. U. (author), Zhou, J. (author), Pufe, T. (author), Wang, L. . (author), Zadpoor, A.A. (author), Jahr, H. (author)
Additively manufactured (AM) degradable porous metallic biomaterials offer unique opportunities for satisfying the design requirements of an ideal bone substitute. Among the currently available biodegradable metals, iron has the highest elastic modulus, meaning that it would benefit the most from porous design. Given the successful...
journal article 2023
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Mirzaali, Mohammad J. (author), Shahriari, N.S. (author), Zhou, J. (author), Zadpoor, A.A. (author)
Additive manufacturing (AM) technologies, particularly those based on powder bed fusion (PBF), most notably, selective laser melting (SLM) for metals, have in recent years emerged as unique fabrication methods for patient-specific implants made of metals and their alloys. The ability to manufacture complex geometries together with the other...
book chapter 2023
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Dong, J. (author), Tümer, N. (author), Leeflang, M.A. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zadpoor, A.A. (author), Zhou, J. (author)
Porous biodegradable Mg and its alloys are considered to have a great potential to serve as ideal bone substitutes. The recent progress in additive manufacturing (AM) has prompted its application to fabricate Mg scaffolds with geometrically ordered porous structures. Extrusion-based AM, followed by debinding and sintering, has been recently...
journal article 2022
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Nouri Goushki, M. (author), Eijkel, B.I.M. (author), Minneboo, M.B. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)
Modulation of the immune response following the implantation of biomaterials can have beneficial effects on bone regeneration. This involves complex interactions between the inflammatory and osteogenic cells. Therefore, the study of cell-cell interactions using direct co-culture models integrated with biomaterials is of great interest. This...
journal article 2022
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Oldhoff, M. G.E. (author), Mirzaali, Mohammad J. (author), Tümer, N. (author), Zhou, J. (author), Zadpoor, A.A. (author)
Additive manufacturing (AM) offers great design freedom that enables objects with desired unique and complex geometry and topology to be readily and cost-effectively fabricated. The overall benefits of AM are well known, such as increased material and resource efficiency, enhanced design and production flexibility, the ability to create...
journal article 2021
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Kolken, H.M.A. (author), Garcia, A. Fontecha (author), Du Plessis, A. (author), Rans, C.D. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)
Meta-biomaterials offer a promising route towards the development of life-lasting implants. The concept aims to achieve solutions that are ordinarily impossible, by offering a unique combination of mechanical, mass transport, and biological properties through the optimization of their small-scale geometrical and topological designs. In this...
journal article 2021
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van Hengel, I.A.J. (author), Lacin, M. (author), Minneboo, M.B. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)
Surface biofunctionalization is frequently applied to enhance the functionality and longevity of orthopedic implants. Here, we investigated the osteogenic effects of additively manufactured porous Ti6Al4V implants whose surfaces were biofunctionalized using plasma electrolytic oxidation (PEO) in Ca/P-based electrolytes with or without...
journal article 2021
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Li, Y. (author), Jahr, H. (author), Zhou, J. (author), Zadpoor, A.A. (author)
Partially due to the unavailability of ideal bone substitutes, the treatment of large bony defects remains one of the most important challenges of orthopedic surgery. Additively manufactured (AM) biodegradable porous metals that have emerged since 2018 provide unprecedented opportunities for fulfilling the requirements of an ideal bone...
review 2020
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Kolken, H.M.A. (author), Lietaert, K. (author), van der Sloten, T. (author), Pouran, B. (author), Meynen, A. (author), Van Loock, G. (author), Weinans, Harrie (author), Scheys, L. (author), Zadpoor, A.A. (author)
The innovative design of orthopedic implants could play an important role in the development of life-lasting implants, by improving both primary and secondary implant fixations. The concept of meta-biomaterials aims to achieve a unique combination of mechanical, mass transport, and biological properties through optimized topological design of...
journal article 2020
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van Hengel, I.A.J. (author), Gelderman, F. S.A. (author), Athanasiadis, S. (author), Minneboo, M.B. (author), Weinans, Harrie (author), Fluit, A. C. (author), van der Eerden, B.C.J. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)
The holy grail of orthopedic implant design is to ward off both aseptic and septic loosening for long enough that the implant outlives the patient. Questing this holy grail is feasible only if orthopedic biomaterials possess a long list of functionalities that enable them to discharge the onerous task of permanently replacing the native bone...
journal article 2020
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Putra, N.E. (author), Mirzaali, Mohammad J. (author), Apachitei, I. (author), Zhou, J. (author), Zadpoor, A.A. (author)
The growing interest in multi-functional metallic biomaterials for bone substitutes challenges the current additive manufacturing (AM, =3D printing) technologies. It is foreseeable that advances in multi-material AM for metallic biomaterials will not only allow for complex geometrical designs, but also improve their multi-functionalities by...
review 2020
document
van Hengel, I.A.J. (author), Putra, N.E. (author), Tierolf, M. W.A.M. (author), Minneboo, M.B. (author), Fluit, A. C. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)
Antibiotic-resistant bacteria are frequently involved in implant-associated infections (IAIs), making the treatment of these infections even more challenging. Therefore, multifunctional implant surfaces that simultaneously possess antibacterial activity and induce osseointegration are highly desired in order to prevent IAIs. The incorporation...
journal article 2020
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Karami, K. (author), Blok, A. (author), Weber, L.R.M. (author), Ahmadi, S.M. (author), Petrov, R.H. (author), Nikolic, Ksenija (author), Borisov, E.V. (author), Leeflang, M.A. (author), Ayas, C. (author), Zadpoor, A.A. (author), Mehdipour, M. (author), Reinton, T.E. (author), Popovich, V. (author)
Additive manufacturing technologies in general and laser powder bed fusion (L-PBF) in particular have been on the rise in different applications, including biomedical implants. The effects of the various L-PBF process parameters on the microstructure and properties of Ti6Al4V lattice structures have been studied before. However, the...
journal article 2020
document
Li, Y. (author), Pavanram, P. (author), Zhou, J. (author), Lietaert, K. (author), Taheri, P. (author), Li, W. (author), San, H. (author), Leeflang, M.A. (author), Mol, J.M.C. (author), Jahr, H. (author), Zadpoor, A.A. (author)
Additively manufacturing (AM) opens up the possibility for biodegradable metals to possess uniquely combined characteristics that are desired for bone substitution, including bone-mimicking mechanical properties, topologically ordered porous structure, pore interconnectivity and biodegradability. Zinc is considered to be one of the promising...
journal article 2020
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Dong, J. (author), Li, Y. (author), Lin, P. (author), Leeflang, M.A. (author), van Asperen, S. (author), Yu, K. (author), Tümer, N. (author), Norder, B. (author), Zadpoor, A.A. (author), Zhou, J. (author)
Biodegradable porous magnesium (Mg) scaffolds are promising for application in the regeneration of critical-sized bone defects. Although additive manufacturing (AM) carries the promise of offering unique opportunities to fabricate porous Mg scaffolds, current attempts to apply the AM approach to fabricating Mg scaffolds have encountered some...
journal article 2020
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Li, Y. (author), Lietaert, K. (author), Li, W. (author), Zhang, X.Y. (author), Leeflang, M.A. (author), Zhou, J. (author), Zadpoor, A.A. (author)
The corrosion fatigue behavior of additively manufactured topologically ordered porous iron based on diamond unit cells was studied for the first time to understand its response to cyclic loading in a simulated physiological environment. The material exhibited high fatigue resistance with fatigue strengths being 70% and 65% of yield stress in...
journal article 2019
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Cuellar Lopez, J.S. (author), Smit, G. (author), Plettenburg, D.H. (author), Zadpoor, A.A. (author)
Fabrication of complex and multi-articulated mechanisms is often seen as a time consuming and demanding process. The development of functional multi-articulated mechanisms that could be fabricated in a single step without the need for post-manufacturing assembly is therefore very attractive. Additive manufacturing (AM) has been pointed out as...
review 2018
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