Recording 3D neuronal activity on chip with segmented 3D microelectrode arrays

FET-based integrated charge sensing in a MEM organ-on-chip platform

Enabling actuation and sensing in organs-on-chip using electroactive polymers

•Actuation has been succesfully performed for 2h30 with no side effects nor<br/>delimination of the human tissue <br/>•0.1 % strain has been achieved during the actutaion mode, close to the<br/>strain experienced in vivo by vSMCs <br/>•0.72 V/mm sensitivity has been shown on the sensing mode <br/>•Batch fabrication and downscaling will be...

Interpreting a migraine GWAS using gene expression in healthy human brain

Migraine is a common brain disorder, with a heritability of 50%. Genome-wide association studies have identified several loci, but interpretation remains challenging. We integrated migraine GWAS data with spatial gene expression data of adult brains from the Allen Human Brain Atlas, to identify specific brain regions and molecular pathways...

A 3D microelectrode array to record neural activity at different tissue depths

In vitro study of high-level neurobiological systems requires three-dimensional (3D) neuronal cultures [1]. Meas-uring responses along all three spatial dimensions is critical to record electric activity inside 3D neuronal models, such as organoids and other 3D brain tissue constructs. However, this lies beyond the capacity of 2D microelec-trode...