Innovative Tissue-Engineered Strategies for Osteochondral Defect Repair and Regeneration: Current Progress and Challenges

Clinical treatments for the repair of osteochondral defects (OCD) are merely palliative, not completely curative, and thus enormously unfulfilled challenges. With the in-depth studies of biology, medicine, materials, and engineering technology, the conception of OCD repair and regeneration should be renewed. During the past decades, many...

Coordination Control of Power Flow Controller and Hybrid DC Circuit Breaker in MVDC Distribution Networks

The two main challenges of medium voltage direct current (MVDC) distribution network are the flexible control of power flow (PF) and fault protection. In this paper, the power flow controller (PFC) is introduced to regulate the PF and inhibit the fault current during the DC fault. The coordination strategy of series-parallel PFC (SP-PFC) and...

Functionalized Hydrogels for Articular Cartilage Tissue Engineering

Articular cartilage (AC) is an avascular and flexible connective tissue located on the bone surface in the diarthrodial joints. AC defects are common in the knees of young and physically active individuals. Because of the lack of suitable tissue-engineered artificial matrices, current therapies for AC defects, especially full-thickness AC...

Engineered biochemical cues of regenerative biomaterials to enhance endogenous stem/progenitor cells (ESPCs)-mediated articular cartilage repair

As a highly specialized shock-absorbing connective tissue, articular cartilage (AC) has very limited self-repair capacity after traumatic injuries, posing a heavy socioeconomic burden. Common clinical therapies for small- to medium-size focal AC defects are well-developed endogenous repair and cell-based strategies, including microfracture,...

Power Disequilibrium Suppression in Bipolar DC Distribution Grids By Using A Series-Parallel Power Flow Controller

The unbalanced power between positive and negative poles in a bipolar DC distribution network (DC-DN) generates an unbalanced current at the neutral line, which enlarges the power losses of the system and the voltage deviation of DC loads. An unbalanced power suppression strategy based on a series-parallel power flow controller (SP-PFC) is...

From Short Circuit to Completed Circuit: Conductive Hydrogel Facilitating Oral Wound Healing

The primary challenges posed by oral mucosal diseases are their high incidence and the difficulty in managing symptoms. Inspired by the ability of bioelectricity to activate cells, accelerate metabolism, and enhance immunity, a conductive polyacrylamide/sodium alginate crosslinked hydrogel composite containing reduced graphene oxide (PAA-SA...

A multi-step fast charging-based battery capacity estimation framework of real-world electric vehicles

Accurately evaluating battery degradation is not only crucial for ensuring the safe and reliable operation of electric vehicles (EVs) but also fundamental for their intelligent management and maximum utilization. However, the non-linearity, non-measurability, and multi-stress coupled operating conditions have posed significant challenges for...

An analytical framework for the best–worst method

Since the development of the best–worst method (BWM) in 2015, it has become a popular research focus in multi-criteria decision-making. The original optimization problem of the BWM is a nonlinear min–max model that can lead to multiple optimal solutions, while the linear model of the BWM produces a unique solution. The two models need to be...