Differential Diagnosis and Molecular Stratification of Gastrointestinal Stromal Tumors on CT Images Using a Radiomics Approach

Treatment planning of gastrointestinal stromal tumors (GISTs) includes distinguishing GISTs from other intra-abdominal tumors and GISTs’ molecular analysis. The aim of this study was to evaluate radiomics for distinguishing GISTs from other intra-abdominal tumors, and in GISTs, predict the c-KIT, PDGFRA, BRAF mutational status, and mitotic...

An operational bidding framework for aggregated electric vehicles on the electricity spot market

Fluctuating electricity prices offer potential economic savings for the consumption of electricity by flexible assets such as Electric Vehicles (EVs). This study proposes an operational bidding framework that minimizes the charging costs of an EV fleet by submitting an optimized bid to the day-ahead electricity market. The framework consists...

A machine learning approach for propeller design and optimization: Part II

We propose and analyse an optimization method that uses a machine learning approach to solve multi-objective, constrained propeller optimization problems. The method uses an online learning strategy where explainable supervised classifiers learn the location of the Pareto front and advise search strategies. The classifiers are trained with...

A machine learning approach for propeller design and optimization: Part I

This paper introduces a machine learning approach for optimizing propellers. The method aims to improve the computational cost of optimization by reducing the number of evaluations required to find solutions. This is achieved by directing the search towards design clusters with good performance, i.e. high propulsive efficiency and low...

A gravity assist mapping for the circular restricted three-body problem using Gaussian processes

Inspired by the Keplerian Map and the Flyby Map, a Gravity Assist Mapping using Gaussian Process Regression for the fully spatial Circular Restricted Three-Body Problem is developed. A mapping function for quantifying the flyby effects over one orbital period is defined. The Gaussian Process Regression model is established by proper mean and...

The BRAF P.V600E Mutation Status of Melanoma Lung Metastases Cannot Be Discriminated on Computed Tomography by LIDC Criteria nor Radiomics Using Machine Learning

Patients with BRAF mutated (BRAF-mt) metastatic melanoma benefit significantly from treatment with BRAF inhibitors. Currently, the BRAF status is determined on archival tumor tissue or on fresh tumor tissue from an invasive biopsy. The aim of this study was to evaluate whether radiomics can predict the BRAF status in a non-invasive manner....

Differential diagnosis and mutation stratification of desmoid-type fibromatosis on MRI using radiomics

Purpose: Diagnosing desmoid-type fibromatosis (DTF) requires an invasive tissue biopsy with β-catenin staining and CTNNB1 mutational analysis, and is challenging due to its rarity. The aim of this study was to evaluate radiomics for distinguishing DTF from soft tissue sarcomas (STS), and in DTF, for predicting the CTNNB1 mutation types....