document

Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration

Coutinho de Almeida, Rodrigo (author), Mahfouz, A.M.E.T.A. (author), Mei, Hailiang (author), Houtman, Evelyn (author), den Hollander, Wouter (author), Soul, Jamie (author), Suchiman, Eka (author), Nelissen, R.G.H.H. (author), Reinders, M.J.T. (author)

OBJECTIVE: To identify OA subtypes based on cartilage transcriptomic data in cartilage tissue and characterize their underlying pathophysiological processes and/or clinically relevant characteristics. METHODS: This study includes n = 66 primary OA patients (41 knees and 25 hips), who underwent a joint replacement surgery, from which...

journal article 2021

document

Temporal structure of brain oscillations predicts learned nocebo responses to pain

Thomaidou, Mia A. (author), Blythe, Joseph S. (author), Houtman, Simon J. (author), Veldhuijzen, Dieuwke S. (author), van Laarhoven, Antoinette I.M. (author), Evers, A.W.M. (author)

This study aimed to identify electrophysiological correlates of nocebo-augmented pain. Nocebo hyperalgesia (i.e., increases in perceived pain resulting from negative expectations) has been found to impact how healthy and patient populations experience pain and is a phenomenon that could be better understood in terms of its neurophysiological...

journal article 2021

document

Perspectives of coagulation/flocculation for the removal of pharmaceuticals from domestic wastewater: A critical view at experimental procedures

Kooijman, G. (author), de Kreuk, M.K. (author), Houtman, C. (author), van Lier, J.B. (author)

Literature frequently reports that colloids in aqueous matrices sorb a large fraction of pharmaceuticals. Since coagulation/flocculation removes colloids, it is expected that coagulation/flocculation in principle should be useful in concentrating pharmaceuticals in wastewater treatment, which would facilitate the treatment of these refractory...

journal article 2020

document

Corticosteroid Action in the Brain: The Potential of Selective Receptor Modulation

Viho, Eva M.G. (author), Buurstede, Jacobus C. (author), Mahfouz, A.M.E.T.A. (author), Koorneef, Lisa L. (author), Van Weert, Lisa T.C.M. (author), Houtman, René (author), Hunt, Hazel J. (author), Kroon, Jan (author), Meijer, Onno C. (author)

Glucocorticoid hormones have important effects on brain function in the context of acute and chronic stress. Many of these are mediated by the glucocorticoid receptor (GR). GR has transcriptional activity which is highly context-specific and differs between tissues and even between cell types. The outcome of GR-mediated transcription depends...

journal article 2019

document

RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage

Coutinho de Almeida, Rodrigo (author), Ramos, Yolande F.M. (author), Mahfouz, A.M.E.T.A. (author), den Hollander, Wouter (author), Lakenberg, Nico (author), Houtman, Evelyn (author), van Hoolwerff, Marcella (author), Suchiman, H. Eka D. (author), Rodriguez-Ruiz, Alejandro (author), Slagboom, P. Eline (author), Mei, Hailiang (author), Kielbasa, Szymon M. (author), Nelissen, R.G.H.H. (author), Reinders, M.J.T. (author), Meulenbelt, Ingrid (author)

Objective To uncover the microRNA (miRNA) interactome of the osteoarthritis (OA) pathophysiological process in the cartilage.<br/>Methods We performed RNA sequencing in 130 samples (n=35 and n=30 pairs for messenger RNA (mRNA) and miRNA, respectively) on macroscopically preserved and lesioned OA cartilage from the same patient and performed...

journal article 2018

document

Conversion of organic micropollutants with limited bromate formation during the Peroxone process in drinking water treatment

Knol, A.H. (author), Lekkerkerker-Teunissen, K. (author), Houtman, C.J. (author), Scheideler, J. (author), Ried, A. (author), Van Dijk, J.C. (author)

Advanced oxidation with O3 / H2O2 (peroxone) was conducted on pilot plant scale on pre-treated Meuse river water to investigate the conversion of organic micropollutants (OMPs) and the formation of bromate. Fourteen selected model compounds were dosed to the pre-treated river water on a regular basis to assess the efficiency of the peroxone...

journal article 2015

document

The structural feasibility of 3D-printing houses using printable polymers

Van der Veen, A.C. (author), Coenders, J.L. (author), Veer, F.A. (author), Nijsse, R. (author), Houtman, R. (author), Schonwalder, J. (author)

At this point in time, 3D-printing techniques in general, but especially applied for the building industry, still are in a phase of early experiments. One of the experimental attempts is to print a full-scale, three-story high, house in Amsterdam, using an up scaled version of a FDM-printer that is able to print blocks of 1.8 x 1.8 x 3.0 meters...

conference paper 2015

document

Medicinal footprint of the population of the Rhine basin

Hut, R.W. (author), Van de Giesen, N.C. (author), Houtman, C.J. (author)

lecture notes 2014

document

Medicinal footprint of the population of the Rhine basin

Hut, R. (author), Van de Giesen, N. (author), Houtman, C.J. (author)

The relation between pharmaceutical residues along the river Rhine and the demographic characteristics of the upstream population was studied. A sampling campaign was performed in which water samples from the Rhine were taken at 42 locations. Measurements were compared to a two parameter model with regional demographic data as main input. For 12...

journal article 2013

document

Innovation opportunities in chemical shipping learning from container shipping and an evaluation of different chemical tanker design concepts

Houtman, R. (author)

other 2002

document

Innovation opportunities in chemical shipping

Houtman, R. (author)

master thesis 2002

document

Base flow and exhaust plume interaction. Part 2: Computational study

Schoones, M.M.J. (author), Houtman, E.M. (author)

A computational study of the flow field along an axi-symmetric body with a single operating exhaust nozzle has been performed in the scope of an investigation on base flow-jet plume interactions. Results of a single nozzle plume with a high supersonic exit Mach number of 4 exhausting in co-flowing supersonic free stream of Mach 2.98 are...

book 1998

document

Experimental and computational study of a blunt cylinder-flare model in high supersonic flow

Houtman, E.M. (author), Bannink, W.J. (author), Timmerman, B.H. (author)

book 1998

document

Preliminary study of a plug nozzle model in supersonic flow

Bannink, W.J. (author), Houtman, E.M. (author), Schoones, M.M.J. (author)

report 1998

document

Experimental and computational study of a blunt cylinder-flare model in high supersonic flow

Houtman, E.M. (author), Bannink, W.J. (author), Timmerman, B.H. (author)

report 1995

document

Modelling of separation using Euler methods

Houtman, E.M. (author), Bakker, P.G. (author), de Vries, E. (author), van den Berg, J.C. (author)

report 1994

document

Investigation of the Vortex flow over a sharp-edged delta wing in the transonic speed regime

Bannink, W.J. (author), Houtman, E.M. (author), Ottochian, S.P. (author)

report 1989

document

The calibration and measuring procedure of a five-hole hemispherical head probe in compressible flow

Houtman, E.M. (author), Bannink, W.J. (author)

report 1989

document

Ontwikkeling van een evenwichtstoedelingsmodel voor meerdere voertuigtypen

Houtman, J.W. (author), Van der Vlist, M. (author)

Rapport in opdracht van Rijkswaterstaat. Doelstelling van het onderzoek is het ontwikkelen van een algoritme voor de simultane toedeling van meerdere scheepstypen aan een vaarwegennet, rekening houdend met verschillen in bevaarbaarheid, onderlinge interacties en congestie. Traditionele toedelingsmodellen voor het autoverkeer schieten hiervoor...

report 1987

document

Experimental investigation of the transonic flow at the Leeward side of a delta wing at high incidence

Houtman, E.M. (author), Bannink, W.J. (author)

report 1987