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Marciniak, B.C. (author), Pabijaniak, M. (author), De Jong, A. (author), Dühring, R. (author), Seidel, G. (author), Hillen, W. (author), Kuipers, O.P. (author)
Background: In Bacillus subtilis and its relatives carbon catabolite control, a mechanism enabling to reach maximal efficiency of carbon and energy sources metabolism, is achieved by the global regulator CcpA (carbon catabolite protein A). CcpA in a complex with HPr-Ser-P (seryl-phosphorylated form of histidine-containing protein, HPr) binds to...
journal article 2012
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De Jong, A. (author), Pietersma, H. (author), Cordes, M. (author), Kuipers, O.P. (author), Kok, J. (author)
Background: Accurate prediction of DNA motifs that are targets of RNA polymerases, sigma factors and transcription factors (TFs) in prokaryotes is a difficult mission mainly due to as yet undiscovered features in DNA sequences or structures in promoter regions. Improved prediction and comparison algorithms are currently available for identifying...
journal article 2012
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Van Zutphen, T. (author), Baerends, R.J.S. (author), Susanna, K.A. (author), De Jong, A. (author), Kuipers, O.P. (author), Veenhuis, M. (author), Van der Klei, I.J. (author)
Background: Methylotrophic yeast species (e.g. Hansenula polymorpha, Pichia pastoris) can grow on methanol as sole source of carbon and energy. These organisms are important cell factories for the production of recombinant proteins, but are also used in fundamental research as model organisms to study peroxisome biology. During exponential...
journal article 2010