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Trebotich, D. (author), Miller, G.H. (author), Bybee, M.D. (author)We present a new method for particle interactions in polymer models of DNA. The DNA is represented by a bead-rod polymer model. The main objective in this work is to implement short range forces to properly model polymer-polymer and polymer-surface interactions. We will discuss two methods for these interactions: (1) a new rigid constraint...conference paper 2006
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Vigneaux, P. (author)The field of microfluidics has dramatically improved over the last decade: it enables the transport of minuscule amounts of fluid (nanolitres) through channels the diameter of a single human hair. This miniaturization is increasingly employed to build a wide range of technological devices for example, genome sequencing or using microdroplets as...conference paper 2006
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Okkels, F. (author), Bruus, H. (author)We address the design of optimal reactors for supporting biological cultures using the method of topology optimization. For some years this method have been used to design various optimal microfluidic devices [1, 2, 3, 4]. We apply this method to distribute optimally biologic cultures within a flow of nutrition. From this optimized distribution...conference paper 2006
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Chen, P.W. (author), Neuser, S. (author), Michaud, V. (author), Studart, A.R. (author)Abstract only.conference paper 2013
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Reese, J.M. (author), Zheng, Y. (author), Lockerby, D.A. (author)In order to capture critical near-wall phenomena in gas micro- and nanoflows within conventional CFD codes, we present scaled Navier-Stokes-Fourier (NSF) constitutive relations. Our scaling is mathematically equivalent to applying an 'effective' viscosity to the original constitutive relations. An expression for this 'effective' transport...conference paper 2006
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Motreuil-Ragot, P.A. (author), Turcan, G. (author), de Wagenaar, B. (author), Hunt, A. (author), Sarro, Pasqualina M (author), Mastrangeli, Massimo (author)Sensing flow rates in structured microenvironments like lab-on-chip (LOC) and organ-on-chip (OoC) is crucial to assess important parameters such as transport of media and molecules of interest. So far, these micro-electromechanical systems for biology (bio-MEMS) mostly rely on flow sensing systems based on thermal sensors. However, thermal...conference paper 2022
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Aydin, E. (author), Makinwa, K.A.A. (author)This paper presents a portable and contactless microfluidic flowmeter based on the Nuclear Magnetic Resonance (NMR) principle, which can measure flow rates up to 2.7 ml/min with \pm 16\ lmin (±0.6% full-scale) error. It consists of a millimeter-size RF coil wound around a microfluidic channel, custom readout electronics and a 0.5 T permanent...conference paper 2021
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Wu, F. (author)One of the most basic features that pervade biology is the existence of boundaries that separate living cells from their outer environments. Molecules responsible for the internal organization of a living cell must adapt to its boundaries, as the cell grows, divides, and changes in shape and size. In this thesis, we aim to understand how...doctoral thesis 2015
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Huang, Z. (author)Heterogeneity is a general feature in biological system. In order to avoid possible misleading effects of ensemble averaging, and to ensure a correct understanding of the biological system, it is very important to look into individuals, such as a single bio-molecule or a single cell, for details. The size of a single bio-molecule/cell typically...doctoral thesis 2012
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Gude, S. (author)Quantitative experiments with the ability to systematically probe the system under investigation are a key element to gain insight and understanding. We present a novel and simple technique enabling the maintenance and controlled perturbation of experimental conditions of microorganisms from bacteria to nematodes. Polyacrylamide-based devices...doctoral thesis 2016
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Mokkapati, V.R.S.S. (author)Research in the field of Micro/nanofluidics has been extensively carried out for the last few years. With the available technological advancements today many complex systems can be fabricated in a more efficient and simpler way. Conventional methods in a laboratory consumes a lot of time, chemicals and in turn generates a lot of waste unlike the...doctoral thesis 2011
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Zhang, L. (author)There was an explosive growth in the bioprocess industry market during the last decade. The tight control of these processes is often very critical in order to optimize the process efficiency or even achieve the right product. Capillary electrophoresis (CE) system is a good option for process monitoring and controlling, since it has already been...doctoral thesis 2009
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- Boulineau, S. (author) doctoral thesis 2013
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Van Steijn, V. (author)Precise manipulation of minute volumes of fluids is at the heart of microfluidics and opens up an exciting route to miniaturize processes in the areas of chemistry, biology and medicine. An attractive way to transport small fluid samples through the channels of microfluidic devices is by enclosing these samples inside containers in the form of...doctoral thesis 2010
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Dorsman, R. (author)Many processes exist in which a thin film is deposited from the gas phase, e.g. Chemical Vapor Deposition (CVD). These processes are operated at ever decreasing reactor operating pressures and with ever decreasing wafer feature dimensions, reaching into the rarefied flow regime. As numerical simulation tools are frequently used to design and...doctoral thesis 2007
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- Van Guijt, R.M. (author) doctoral thesis 2003
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Muralidharan, A. (author)Delivery of biomolecules using pulsed electric fields or electrotransfer has applications such as biomedical engineering, bioprocess engineering and genomic engineering. When a cell is placed in an electric field, the induced transmembrane voltage catalyzes the formation of pores on the cell membrane. This enables the delivery of otherwise cell...doctoral thesis 2022
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- Sachdev, S. (author) doctoral thesis 2020
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Fanalista, F. (author)Cell replication is a fascinating biological process that ensures the proliferation of a species via division of a mother cell into two daughter ones. This process in bacteria is performed by a complex protein machinery named the Z-ring, which assembles at the cell mid-plane and promotes progressive membrane constriction down to division. A...doctoral thesis 2020
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Tiruvadi Krishnan, S. (author)All living organisms pass on their genetic information to their offspring in the form of DNA or RNA molecules by duplicating them across generations. In the bacteria, their genes are packed in long chains of DNA molecules or chromosomes. One of the widely studied model organisms, Escherichia coli, replicates its circular chromosome in two...doctoral thesis 2016