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de Jong, Sanne E. (author), van Unen, Vincent (author), Manurung, Mikhael D. (author), Jochems, Simon P. (author), Höllt, T. (author), Pezzotti, N. (author), Eisemann, E. (author), Lelieveldt, B.P.F. (author), Reinders, M.J.T. (author)Controlled human infections provide opportunities to study the interaction between the immune system and malaria parasites, which is essential for vaccine development. Here, we compared immune signatures of malaria-naive Europeans and of Africans with lifelong malaria exposure using mass cytometry, RNA sequencing and data integration, before...journal article 2021
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van Unen, Vincent (author), Höllt, T. (author), Pezzotti, N. (author), Li, Na (author), Reinders, M.J.T. (author), Eisemann, E. (author), Koning, Frits (author), Vilanova Bartroli, A. (author), Lelieveldt, B.P.F. (author)Mass cytometry allows high-resolution dissection of the cellular composition of the immune system. However, the high-dimensionality, large size, and non-linear structure of the data poses considerable challenges for the data analysis. In particular, dimensionality reduction-based techniques like t-SNE offer single-cell resolution but are...journal article 2017
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Huisman, S.M.H. (author), Van Lew, B. (author), Mahfouz, A.M.E.T.A. (author), Pezzotti, N. (author), Höllt, T. (author), Michielsen, L.C.M. (author), Vilanova Bartroli, A. (author), Reinders, M.J.T. (author), Lelieveldt, B.P.F. (author)Spatial and temporal brain transcriptomics has recently emerged as an invaluable data source for molecular neuroscience. The complexity of such data poses considerable challenges for analysis and visualization. We present BrainScope: A web portal for fast, interactive visual exploration of the Allen Atlases of the adult and developing human...journal article 2017