EDEN: A High-Performance, General-Purpose, NeuroML-Based Neural Simulator

Modern neuroscience employs in silico experimentation on ever-increasing and more detailed neural networks. The high modeling detail goes hand in hand with the need for high model reproducibility, reusability and transparency. Besides, the size of the models and the long timescales under study mandate the use of a simulation system with high...

Parallel Scalability of Three-Level FROSch Preconditioners to 220000 Cores using the Theta Supercomputer

The parallel performance of the three-level fast and robust overlapping Schwarz (FROSch) preconditioners is investigated for linear elasticity. The FROSch framework is part of the Trilinos software library and contains a parallel implementation of different preconditioners with energy minimizing coarse spaces of generalized Dryja--Smith--Widlund...

iRASPA: GPU-accelerated visualization software for materials scientists

A new macOS software package, iRASPA, for visualisation and editing of materials is presented. iRASPA is a document-based app that manages multiple documents with each document containing a unique set of data that is stored in a file located either in the application sandbox or in iCloud drive. The latter allows collaboration on a shared...

The MADP Toolbox: An Open Source Library for Planning and Learning in (Multi-)Agent Systems

This article describes the MultiAgent Decision Process (MADP) toolbox, a software library to support planning and learning for intelligent agents and multiagent systems in uncertain environments. Key features are that it supports partially observable environments and stochastic transition models; has unified support for single- and multiagent...

On computing the maximum parsimony score of a phylogenetic network

Phylogenetic networks are used to display the relationship among different species whose evolution is not treelike, which is the case, for instance, in the presence of hybridization events or horizontal gene transfers. Tree inference methods such as maximum parsimony need to be modified in order to be applicable to networks. In this paper, we...

Precise and unbiased estimation of astigmatism and defocus in transmission electron microscopy

Defocus and twofold astigmatism are the key parameters governing the contrast transfer function (CTF) in transmission electron microscopy (TEM) of weak phase objects. We present a new algorithm to estimate these aberrations and the associated uncertainties. Tests show very good agreement between simulated and estimated defocus and astigmatism....