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A data-driven methodology reveals novel myofiber clusters in older human muscles

Raz, Yotam (author), van den Akker, E.B. (author), Roest, Tijmen (author), Riaz, Muhammad (author), van de Rest, Ondine (author), Suchiman, H. Eka D. (author), Lakenberg, Nico (author), Stassen, Stefanie A. (author), Reinders, M.J.T. (author)

Skeletal muscles control posture, mobility and strength, and influence whole-body metabolism. Muscles are built of different types of myofibers, each having specific metabolic, molecular, and contractile properties. Fiber classification is, therefore, regarded the key for understanding muscle biology, (patho-) physiology. The expression of...

journal article 2020

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A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly

Quiros Solano, W.F. (author), Gaio, N. (author), Silvestri, C. (author), Arik, Y.B. (author), Stassen, O.M.J.A. (author), van der Meer, A.D. (author), Bouten, C.V.C. (author), van den Berg, A. (author), Dekker, R. (author), Sarro, Pasqualina M (author)

We present a novel method to easily and reliably transfer highly porous, large area, thin microfabricated Polydimethylsiloxane (PDMS) porous membranes on Lab-on-Chip (LOC) and Organ-on-Chip (OOC) devices. The use of silicon as carrier substrate and a water-soluble sacrificial layer allows a simple and reproducible transfer of the membranes to...

conference paper 2018

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Microfabricated tuneable and transferable porous PDMS membranes for Organs-on-Chips

Quiros Solano, W.F. (author), Gaio, N. (author), Stassen, O.M.J.A. (author), Arik, Y.B. (author), Silvestri, C. (author), Van Engeland, N.C.A. (author), Van der Meer, A. (author), Passier, R. (author), Sahlgren, C.M. (author), Bouten, C.V.C. (author), van den Berg, A. (author), Dekker, R. (author), Sarro, Pasqualina M (author)

We present a novel and highly reproducible process to fabricate transferable porous PDMS membranes for PDMS-based Organs-on-Chips (OOCs) using microelectromechanical systems (MEMS) fabrication technologies. Porous PDMS membranes with pore sizes down to 2.0 μm in diameter and a wide porosity range (2–65%) can be fabricated. To overcome issues...

journal article 2018

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Implications of the law on video recording in clinical practice

Henken, K.R. (author), Jansen, F.W. (author), Klein, J. (author), Stassen, L.P.S. (author), Dankelman, J. (author), Van den Dobbelsteen, J.J. (author)

Background Technological developments allow for a variety of applications of video recording in health care, including endoscopic procedures. Although the value of video registration is recognized, medicolegal concerns regarding the privacy of patients and professionals are growing. A clear understanding of the legal framework is lacking....

journal article 2012

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Requirements for the design and implementation of checklists for surgical processes

Verdaasdonk, E.G.G. (author), Stassen, L.P.S. (author), Widhiasmara, P.P. (author), Dankelman, J. (author)

Background- The use of checklists is a promising strategy for improving patient safety in all types of surgical processes inside and outside the operating room. This article aims to provide requirements and implementation of checklists for surgical processes. Methods- The literature on checklist use in the operating room was reviewed based on...

journal article 2008

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Can a structured checklist prevent problems with laparoscopic equipment?

Verdaasdonk, E.G.G. (author), Stassen, L.P.S. (author), Hoffmann, W.F. (author), Van der Elst, M. (author), Dankelman, J. (author)

Background A high incidence of problems with the technical equipment is known to occur during routine laparoscopic procedures. Use of a structured checklist of preparatory measures could help to prevent these problems. This study aimed to determine the extent to which a checklist reduced the number of incidents with technical laparoscopic...

journal article 2008

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Incorporation of proficiency criteria for basic laparoscopic skills training: How does it work?

Verdaasdonk, E.G. (author), Dankelman, J. (author), Lange, J.F. (author), Stassen, L.P.S. (author)

Background - It is desirable that surgical trainees are proficient in basic laparoscopic motor skills (eye–hand coordination). The present study evaluated the use of predefined proficiency criteria on a basic virtual reality (VR) simulator in preparation for a laparoscopic course on animal models. Methods - Twenty-eight surgical trainees who...

journal article 2008

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Transfer validity of laparoscopic knot-tying training on a VR simulator to a realistic environment: A randomized controlled trial

Verdaasdonk, E.G.G. (author), Dankelman, J. (author), Lange, J.F. (author), Stassen, L.P.S. (author)

Background- Laparoscopic suturing is one of the most difficult tasks in endoscopic surgery, requiring extensive training. The aim of this study was to determine the transfer validity of knot-tying training on a virtual-reality (VR) simulator to a realistic laparoscopic environment. Methods- Twenty surgical trainees underwent basic eye–hand...

journal article 2007

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New Technologies Supporting Surgical Interventions and Training of Surgical Skills: A Look at Projects in Europe Supporting Minimally Invasive Techniques

Dankelman, J. (author), Grimbergen, C.A. (author), Stassen, H.G. (author)

journal article 2007

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Problems with technical equipment during laparoscopic surgery - An observational study

Verdaasdonk, E.G.G. (author), Stassen, L.P.S. (author), Van Der Elst, M. (author), Karsten, T.M. (author), Dankelman, J. (author)

journal article 2007

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Analysis of verbal communication during teaching in the operating room and the potentials for surgical training

Blom, E.M. (author), Verdaasdonk, E.G.G. (author), Stassen, L.P.S. (author), Stassen, H.G. (author), Wieringa, P.A. (author), Dankelman, J. (author)

journal article 2007

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Construct validity and assessment of the learning curve for the SIMENDO endoscopic simulator

Verdaasdonk, E.G.G. (author), Stassen, L.P.S. (author), Schijven, M.P. (author), Dankelman, J. (author)

journal article 2007

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The influence of different training schedules on the learning of psychomotor skills for endoscopic surgery

Verdaasdonk, E.G.G. (author), Stassen, L.P.S. (author), Van Wijk, R.P.J. (author), Dankelman, J. (author)

journal article 2007

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Ambipolar Cu- and Fe-phthalocyanine single-crystal field-effect transistors

De Boer, R.W.I. (author), Stassen, A.F. (author), Craciun, M.F. (author), Mulder, C.L. (author), Molinari, A. (author), Rogge, S. (author), Morpurgo, A.F. (author)

We report the observation of ambipolar transport in field-effect transistors fabricated on single crystals of copper- and iron-phthalocyanine, using gold as a high work-function metal for the fabrication of source and drain electrodes. In these devices, the room-temperature mobility of holes reaches 0.3?cm2/V?s in both materials. The highest...

journal article 2005

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Influence of the gate leakage current on the stability of organic single-crystal field-effect transistors

De Boer, R.W.I. (author), Iosad, N.N. (author), Stassen, A.F. (author), Klapwijk, T.M. (author), Morpurgo, A.F. (author)

We investigate the effect of a small leakage current through the gate insulator on the stability of organic single-crystal field-effect transistors (FETs). We find that, irrespective of the specific organic molecule and dielectric used, leakage current flowing through the gate insulator results in an irreversible degradation of the single...

journal article 2005

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Influence of the gate dielectric on the mobility of rubrene single-crystal field-effect transistors

Stassen, A.F. (author), De Boer, R.W.I. (author), Iosad, N.N. (author), Morpurgo, A.F. (author)

We have performed a comparative study of rubrene single-crystal field-effect transistors fabricated using different materials as gate insulator. For all materials, highly reproducible device characteristics are obtained. The achieved reproducibility permits one to observe that the mobility of the charge carriers systematically decreases with...

journal article 2004

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The Perspective Effect of Wide-Angle Lenses in Laparoscopes

Wentink, M. (author), Fischer, H. (author), Dankelman, J. (author), Stassen, L.P.S. (author), Wieringa, P.A. (author)

Purpose: To evaluate the effect of perspective distortion of wide-angle lenses in laparoscopes on hand-eye coordination during endoscopic manipulation. Methods: Sixteen subjects repeatedly performed a standardized positioning task in a pelvi-trainer under two conditions. The subjects had no prior experience with endoscopic manipulation. In one...

journal article 2002

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Mens-machine systemen: Van industriële naar medische toepassing

Stassen, H.G. (author)

public lecture 2002

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Observation in Laparoscopic Surgery: Overview of Impeding Effects and Supporting Aids

Breedveld, P. (author), Stassen, H.G. (author), Meijer, D.W. (author), Jakimowicz, J.J. (author)

Within a Dutch research program on minimally invasive surgery, a large literature survey has been carried out. This article describes the state of the art in research on observation in laparoscopy. It gives an overview of factors impeding the surgeon and technical developments designed to overcome these problems. A large number of journals,...

journal article 2000

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Developments in minimally invasive surgery and interventional techniques (misit)

Stassen, H.G. (author), Dankelman, J. (author), Grimb, C.A. (author)

conference paper 1997