Electrochemical Amplification in Side-by-Side Attoliter Nanogap Transducers

We report a strategy for the fabrication of a new type of electrochemical nanogap transducer. These nanogap devices are based on signal amplification by redox cycling. Using two steps of electron-beam lithography, vertical gold electrodes are fabricated side by side at a 70 nm distance encompassing a 20 attoliter open nanogap volume. We...

Microfluidic microneedle or micropipet comprising a nanogap sensor for analytical applications

The invention provides asensor device comprising a substrate, especially a needle with a needle tip, wherein the substrate, especially the needle, even more especially the needle tip, comprises a sensor unit, wherein the sensor unit includes a stacked layer structure including an electrode layer, wherein the stacked layer structure further...

Synthesis and Characterization of Porous Carbon-MoS2 Nanohybrid Materials for Charge-Enhanced Electrocatalysis

Porous carbon nanohybrids are promising materials as high-performance electrodes for both sensing and energy conversion applications. This is mainly due to their high specific surface area and specific physicochemical properties. Here, new porous nanohybrid materials are developed based on exfoliated MoS2 nanopetals and either negatively charged...

Covalent immobilization of glucose oxidase on amino MOFs via post-synthetic modification

The post-synthetic modification (PSM) of two amino-MOFs with glucose oxidase is reported in this study. The multi-step approach preserved the MOFs' structure and allowed the production of enzyme-functionalized MOFs (MOFs@GOx), which retained the enzymatic activity and showed selective properties for glucose.

Polymers of Intrinsic Microporosity as High Temperature Templates for the Formation of Nanofibrous Oxides

The highly rigid molecular structure of Polymers of Intrinsic Microporosity (PIM) – associated with a high thermolysis threshold – combined with the possibility to fill intrinsic micropores allows the direct “one-step” templated conversion of metal nitrates into nano-structured metal oxides. This is demonstrated here with PIM-EA-TB and with PIM...

Facile formation of ZIF-8 thin films on ZnO nanorods

In this work, thin films of the well-known metal–organic framework ZIF-8 were formed on zinc oxide nanorods through the reaction with 2-methyl-imidazole solution (Hmim). Deposition of a thin film of the linker solution allows the underlying zinc oxide nanorod morphology to be preserved, resulting in the facile and precise formation of...

Substrate-dependent kinetics in tyrosinase-based biosensing: Amperometry vs. spectrophotometry

Despite the broad use of enzymes in electroanalytical biosensors, the influence of enzyme kinetics on the function of prototype sensors is often overlooked or neglected. In the present study, we employ amperometry as an alternative or complementary method to study the kinetics of tyrosinase, whose catalytic activity results in o-quinone products...