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Noninvasive Advanced Cardiovascular Magnetic Resonance-Derived Fontan Hemodynamics Are Associated With Reduced Kidney Function But Not Albuminuria

Van den Eynde, Jef (author), Westenberg, Jos J.M. (author), Hazekamp, Mark G. (author), Lamb, Hildo J. (author), Jongbloed, Monique R.M. (author), Wentzel, Jolanda J. (author), Kenjeres, S. (author), Dekkers, Ilona A. (author), Rijnberg, F.M. (author)

BACKGROUND: Kidney disease is the most important predictor of death in patients with a Fontan circulation, yet its clinical and hemodynamic correlates have not been well established. METHODS AND RESULTS: A total of 53 ambulatory patients with a Fontan circulation (median age, 16.2 years, 52.8% male patients) underwent advanced cardiovascular...

journal article 2024

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Folding pathway of a discontinuous two-domain protein

Agam, Ganesh (author), Barth, A. (author), Lamb, Don C. (author)

It is estimated that two-thirds of all proteins in higher organisms are composed of multiple domains, many of them containing discontinuous folds. However, to date, most in vitro protein folding studies have focused on small, single-domain proteins. As a model system for a two-domain discontinuous protein, we study the unfolding/refolding of...

journal article 2024

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Flow patterns in ascending aortic aneurysms: Determining the role of hypertension using phase contrast magnetic resonance and computational fluid dynamics

Ramaekers, M. J.F.G. (author), van der Vlugt, I.B. (author), Westenberg, J. J.M. (author), Perinajová, R. (author), Lamb, H. J. (author), Wildberger, J. E. (author), Kenjeres, S. (author), Schalla, S. (author)

Thoracic aortic aneurysm (TAA) is a local dilation of the thoracic aorta. Although universally used, aneurysm diameter alone is a poor predictor of major complications such as rupture. There is a need for better biomarkers for risk assessment that also reflect the aberrant flow patterns found in TAAs. Furthermore, hypertension is often...

journal article 2024

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Geomorphic risk maps for river migration using probabilistic modeling: a framework

Noh, Brayden (author), Wani, Omar (author), Dunne, K.B.J. (author), Lamb, Michael P. (author)

Lateral migration of meandering rivers poses erosional risks to human settlements, roads, and infrastructure in alluvial floodplains. While there is a large body of scientific literature on the dominant mechanisms driving river migration, it is still not possible to accurately predict river meander evolution over multiple years. This is in part...

journal article 2024

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Influence of aortic aneurysm on the local distribution of NO and O₂ using image-based computational fluid dynamics

Perinajová, R. (author), Álvarez-Cuevas, Concepción Borrás (author), Juffermans, Joe (author), Westenberg, Jos (author), Lamb, Hildo (author), Kenjeres, S. (author)

There is a pressing need to establish novel biomarkers to predict the progression of thoracic aortic aneurysm (TAA) dilatation. Aside from hemodynamics, the roles of oxygen (O₂) and nitric oxide (NO) in TAA pathogenesis are potentially significant. As such, it is imperative to comprehend the relationship between aneurysm presence...

journal article 2023

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Virtual surgery to predict optimized conduit size for adult Fontan patients with 16-mm conduits

Hut, T.Y. (author), Roest, Arno (author), Gaillard, D.H.K. (author), Hazekamp, Mark (author), Van Den Boogaard, Pieter (author), Lamb, Hildo (author), Jongbloed, Monique (author), Rijnberg, Friso (author), Kenjeres, S. (author)

Objectives: Recent evidence suggests that conduits implanted in Fontan patients at the age of 2-4 years become undersized for adulthood. The objective of this study is to use computational fluid dynamic models to evaluate the effect of virtual expansion of the Fontan conduit on haemodynamics and energetics of the total cavopulmonary...

journal article 2023

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Haemodynamic performance of 16–20-mm extracardiac Goretex conduits in adolescent Fontan patients at rest and during simulated exercise

Rijnberg, Friso M. (author), van ‘t Hul, Luca C. (author), Hazekamp, Mark G. (author), van den Boogaard, Pieter J. (author), Juffermans, Joe F. (author), Lamb, Hildo J. (author), Kenjeres, S. (author), le Cessie, Saskia (author), Jongbloed, Monique R.M. (author)

OBJECTIVES: To date, it is not known if 16–20-mm extracardiac conduits are outgrown during somatic growth from childhood to adolescence. This study aims to determine total cavopulmonary connection (TCPC) haemodynamics in adolescent Fontan patients at rest and during simulated exercise and to assess the relationship between conduit size and...

journal article 2023

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Head-to-Head Comparison of T1 Mapping and Electroanatomical Voltage Mapping in Patients With Ventricular Arrhythmias

Sramko, Marek (author), Abdel-Kafi, Saif (author), Wijnmaalen, Adrianus P. (author), Tao, Q. (author), van der Geest, R.J. (author), Lamb, Hildo J. (author), Zeppenfeld, Katja (author)

Background: Electroanatomical voltage mapping (EAVM) has been compared with late gadolinium enhancement cardiovascular magnetic resonance (LGE-CMR), which cannot delineate diffuse fibrosis. T1-mapping CMR overcomes the limitations of LGE-CMR, but it has not been directly compared against EAVM. Objectives: This study aims to assess the...

journal article 2023

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Extracardiac conduit adequacy along the respiratory cycle in adolescent Fontan patients

Rijnberg, Friso M. (author), van der Woude, S.F.S. (author), Hazekamp, Mark G. (author), Van Den Boogaard, Pieter J. (author), Lamb, Hildo J. (author), Terol Espinosa De Los Monteros, Covadonga (author), Kenjeres, S. (author), Karim, Tawab (author), Jongbloed, Monique R.M. (author)

OBJECTIVES: Adequacy of 16-20mm extracardiac conduits for adolescent Fontan patients remains unknown. This study aims to evaluate conduit adequacy using the inferior vena cava (IVC)-conduit velocity mismatch factor along the respiratory cycle. METHODS: Real-time 2D flow MRI was prospectively acquired in 50 extracardiac (16-20mm conduits)...

journal article 2022

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E-health relationships diabetes: 50 weeks evaluation

Simons, L.P.A. (author), Pijl, Hanno (author), Verhoef, John (author), Lamb, Hildo J. (author), van Ommen, Ben (author), Gerritsen, B. (author), Bizino, Maurice B. (author), Snel, Marieke (author), Feenstra, R.W. (author), Jonker, C.M. (author)

Hybrid e-health support was given to 11 insulin-dependent type 2 diabetes mellitus (DM2) patients, with electronic support plus a multi-disciplinary health support team. Challenges were low ICT and health literacy. After 50 weeks, attractiveness and feasibility of the intervention were perceived as high: recommendation 9.5 out of 10 and...

journal article 2022

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Non-uniform mixing of hepatic venous flow and inferior vena cava flow in the Fontan conduit

Rijnberg, Friso M. (author), van der Woude, S.F.S. (author), van Assen, Hans C. (author), Juffermans, J.F. (author), Hazekamp, Mark G. (author), Jongbloed, Monique R.M. (author), Kenjeres, S. (author), Lamb, Hildo J. (author), Westenberg, Jos J.M. (author)

Fontan patients require a balanced hepatic blood flow distribution (HFD) to prevent pulmonary arteriovenous malformations. Currently, HFD is quantified by tracking Fontan conduit flow, assuming hepatic venous (HV) flow to be uniformly distributed within the Fontan conduit. However, this assumption may be unvalid leading to inaccuracies in HFD...

journal article 2021

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Assessment of turbulent blood flow and wall shear stress in aortic coarctation using image-based simulations

Perinajová, R. (author), Juffermans, J.F. (author), Mercado, Jonhatan Lorenzo (author), Aben, Jean Paul (author), Ledoux, Leon (author), Westenberg, Jos J.M. (author), Lamb, Hildo J. (author), Kenjeres, S. (author)

In this study, we analyzed turbulent flows through a phantom (a 180^∘ bend with narrowing) at peak systole and a patient-specific coarctation of the aorta (CoA), with a pulsating flow, using magnetic resonance imaging (MRI) and computational fluid dynamics (CFD). For MRI, a 4D-flow MRI is performed using a 3T scanner. For CFD, the...

journal article 2021

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Geometrically induced wall shear stress variability in CFD-MRI coupled simulations of blood flow in the thoracic aortas

Perinajová, R. (author), Juffermans, Joe F. (author), Westenberg, Jos J.M. (author), van der Palen, Roel L.F. (author), van den Boogaard, Pieter J. (author), Lamb, Hildo J. (author), Kenjeres, S. (author)

Aortic aneurysm is associated with aberrant blood flow and wall shear stress (WSS). This can be studied by coupling magnetic resonance imaging (MRI) with computational fluid dynamics (CFD). For patient-specific simulations, extra attention should be given to the variation in segmentation of the MRI data-set and its effect on WSS. We performed...

journal article 2021

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Observations of Multiple Internal Wave Packets in a Tidal River Plume

Rijnsburger, S. (author), Flores, Raúl P. (author), Pietrzak, J.D. (author), Lamb, Kevin G. (author), Jones, Nicole L. (author), Horner-Devine, Alexander R. (author), Souza, Alejandro J. (author)

Remotely sensed images document the occurrence of multiple packets of internal solitary waves (ISWs) in the Rhine River plume at the same time. We use a combination of field observations, and non-hydrostatic and hydrostatic modeling to understand the processes that lead to the generation and retention of multiple ISW packets within the Rhine...

journal article 2021

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Observations of internal waves in the near field of the Rhine River Plume

Rijnsburger, S. (author), Audibert, Raul Flores (author), Pietrzak, J.D. (author), Horner-Devine, Alexander (author), Souza, Alejandro J. (author), Jones, Nicole (author), Lamb, Kevin (author)

poster 2019

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Super-resolution reconstruction of late gadolinium enhanced MRI from multiple views

Tao, Q. (author), Dzyubachyk, O. (author), Poot, D. (author), Lamb, H.J. (author), Zeppenfeld, K. (author), Lelieveldt, B.P.F. (author), Van der Geest, R.J. (author)

Oral presentation.

lecture notes 2014

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A modified delay-time method for statics estimation with the virtual refraction

Mikesell, T.D. (author), Van Wijk, K. (author), Ruigrok, E.N. (author), Lamb, A. (author), Blum, T.E. (author)

Topography and near-surface heterogeneities lead to traveltime perturbations in surface land-seismic experiments. Usually, these perturbations are estimated and removed prior to further processing of the data. A common technique to estimate these perturbations is the delay-time method. We have developed the “modified delay-time method,” wherein...

journal article 2012

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Ship Design and Construction

Lamb, Thomas (author)

book 2004

document

The advanced outfitting dilemma

Lamb, Thomas (author)

report 2004

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Ship Design and Construction

Lamb, Thomas (author)

book 2003