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Bakhshaee Babaroud, N. (author), Rice, S.J. (author), Camarena, M. (author), Serdijn, W.A. (author), Vollebregt, S. (author), Giagka, Vasiliki (author)In this paper, we present the surface modification of multilayer graphene electrodes with platinum (Pt) nanoparticles (NPs) using spark ablation. This method yields an individually selective local printing of NPs on an electrode surface at room temperature in a dry process. NP printing is performed as a post-process step to enhance the...journal article 2024
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Rashidi, A. (author), Varkevisser, F. (author), Giagka, Vasiliki (author), Lopes Marta da Costa, T.M. (author), Serdijn, W.A. (author)Electrical stimulation is proven to be an effective way of neuromodulation in bioelectronic medicine (e.g. cochlear implants, deep brain stimulators, etc.), delivering localized treatment by the means of electrical pulses. To increase the stimulation efficiency and neural-type selectivity, there is an increasing interest to employ non...abstract 2023
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Rout, Samprajani (author), Monna, G.L.E. (author), Pareschi, Fabio (author), Setti, Gianluca (author), Serdijn, W.A. (author)The key challenges in designing a multi-channel biosignal acquisition system for an ambulatory or invasive medical application with a high channel count are reducing the power consumption, area consumption and the outgoing wire count. This article proposes a spread-spectrum modulated biosignal acquisition system using a shared amplifier and...journal article 2023
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Panskus, R. (author), Holzapfel, L.F.M. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)Recording neuronal activity triggered by electrical impulses is a powerful tool in neuroscience research and neural engineering. It is often applied in acute electrophysiological experimental settings to record compound nerve action potentials. However, the elicited neural response is often distorted by electrical stimulus artifacts,...conference paper 2023
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Pola, M. (author), Giagka, Vasiliki (author), Serdijn, W.A. (author), Demarchi, Danilo (author), Rashidi, A. (author)This paper presents a new communication method between micro-scale freely floating brain implants based on galvanic coupling (GC), called "Brain-Coupled Communication" (BCC). Since the transmission efficiency based on GC is highly dependent on the system’s geometry and the electromagnetic properties of the tissue, finite element models in COMSOL...conference paper 2023
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Rashidi, A. (author), Rivandi, H. (author), Grubor, M. (author), Agostinho, Andre (author), Sadio, Valter (author), Santos, Marcelino (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)This paper presents a novel multi-channel stimulation backend with a multi-bit delta-sigma control loop, which enables precise adjustment of the stimulation current through modulation of the supply voltage. This minimizes the overhead voltage of series circuitry to the stimulation load and avoids the associated energy loss. Additionally, to...conference paper 2023
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Varkevisser, F. (author), Lopes Marta da Costa, T.M. (author), Serdijn, W.A. (author)Developing neuroprosthetic bioelectronic devices requires wirelessly-powered implantable stimulator systems with hundreds to thousands of output channels. Power efficiency optimization is crucial for scaling up the number of output channels. Current-mode electrical stimulation is favored for safety but is power-inefficient in conventional...conference paper 2023
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Velea, A. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)In an attempt to reduce the side effects caused by the chemically-based drugs used to treat neurological disorders, the field of bioelectronics has been focusing on the development of smart and reliable solutions that could, ideally, interact with the tissue at a resolution of individual cells.1 Conventionally, electrically-based systems have...abstract 2022
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Kolovou Kouri, K. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)During the last few decades, electrical neural stimulators have successfully been employed as a means of treatment for a wide range of neurological disorders. By targeting the peripheral and central nervous systems, electrical neurostimulators activate/inhibit neural activity by manipulating the stimulus- induced electric field arising at the...abstract 2022
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Safarpour, Amin (author), Dehnavi, Farzaneh (author), Saberi, Mehdi (author), Lotfi, R. (author), Serdijn, W.A. (author)In multi-electrode arrays (MEAs), for electrical recording and electrical stimulation, high voltage (HV) switches are employed to build an analog multiplexer to conduct either a HV stimulation signal from the pulse generator circuit to an electrode or a low-voltage noise-sensitive signal from the electrode to a recording stage. In this brief,...journal article 2022
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Panskus, R. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)Over the past decades, neuromodulation has been proven to be an effective treatment for several neurological disorders. Moreover, it continues to be a rapidly evolving field with a wide-ranging potential for biomedical applications. However, efficient and patient-specific targeted neuromodulation remains one of the biggest challenges for...abstract 2022
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Varkevisser, F. (author), Lopes Marta da Costa, T.M. (author), Serdijn, W.A. (author)Power efficiency in electrical stimulator circuits is crucial for developing large-scale multichannel applications like bidirectional brain-computer interfaces and neuroprosthetic devices. Many state-of-the-art papers have suggested that some non-rectangular pulse shapes are more energy-efficient for exciting neural excitation than the...journal article 2022
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Siddiqi, M.A. (author), Hahn, Georg (author), Hamdioui, S. (author), Serdijn, W.A. (author), Strydis, C. (author)A Medical Body Area Network (MBAN) is an ensemble of collaborating, potentially heterogeneous, medical devices located inside, on the surface of or around the human body with the objective of tackling one or multiple medical conditions of the MBAN host. These devices-which are a special category of Wireless Body Area Networks (WBANs)–collect,...journal article 2022
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Bakhshaee Babaroud, N. (author), Palmar, M. (author), Velea, A. (author), Coletti, C. (author), Weingärtner, S.D. (author), Vos, F.M. (author), Serdijn, W.A. (author), Vollebregt, S. (author), Giagka, Vasiliki (author)Multimodal platforms combining electrical neural recording and stimulation, optogenetics, optical imaging, and magnetic resonance (MRI) imaging are emerging as a promising platform to enhance the depth of characterization in neuroscientific research. Electrically conductive, optically transparent, and MRI-compatible electrodes can optimally...journal article 2022
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Varkevisser, F. (author), Rashidi, A. (author), Lopes Marta da Costa, T.M. (author), Giagka, Vasiliki (author), Serdijn, W.A. (author)This work proposes a guideline for designing more energy-efficient electrical stimulators by analyzing the frequency spectrum of the stimuli. It is shown that the natural low-pass characteristic of the neuron’s membrane limits the energy transfer efficiency from the stimulator to the cell. Thus, to improve the transfer efficiency, it is proposed...conference paper 2022
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Coolen, R.J.J. (author), Emmer, K.M. (author), Spantidea, P.I. (author), Asselt, E. van (author), Scheepe, J.R. (author), Serdijn, W.A. (author), Blok, B.F.M. (author)The first two objectives were to establish which stimulation parameters of kilohertz frequency alternating current (KHFAC) neuromodulation influence the effectiveness of pudendal nerve block and its safety. The third aim was to determine whether KHFAC neuromodulation of the pudendal nerve can relax the pelvic musculature, including the anal...journal article 2022
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Brash, Rohan (author), Serdijn, W.A. (author), Muratore, D.G. (author)This paper introduces a fast artifact recovery algorithm (FARA) that uses electrochemical impedance spectroscopy to model the electrode-tissue interface and design an optimum stimulation waveform to minimize the residual artifact duration in single-cell resolution neural interfaces. Results in saline solution with a custom PCB and a 30 $\mu ...conference paper 2022
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Dilevicius, Ignas (author), Serdijn, W.A. (author), Lopes Marta da Costa, T.M. (author)Deep brain stimulation is currently the only technique used in the clinical setting to modulate the neural activity of deep brain nuclei. Recently, low-intensity transcranial focused ultrasound (LIFU) has been shown to reversibly modulate brain activity through a transcranial pathway. Transcranial LIFU requires a low-frequency ultrasound of...conference paper 2022
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Kolovou Kouri, K. (author), Rashidi, A. (author), Varkevisser, F. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)In neuromodulation applications, conventional current mode stimulation is often preferred over its voltage mode equivalent due to its good control of the injected charge. However, it comes at the cost of less energy-efficient output stages. To increase energy efficiency, recent studies have explored non-rectangular stimuli. The current work...conference paper 2022
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Kolovou Kouri, K. (author), Soloukey, Sadaf (author), Harhangi, Biswadjiet (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)Spinal Cord Injury (SCI) is characterized by a disruption of the spinal pathways connecting the brain to the rest of the body. This can result in an impairment or complete loss of sensory and/or motor functions, depending on the level and severity of the injury. The most common approach of attempting motor recovery using neuromodulation has been...abstract 2021