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de Vries, Natasja L. (author), van de Haar, Joris (author), Veninga, Vivien (author), Chalabi, Myriam (author), Ijsselsteijn, Marieke E. (author), van der Ploeg, Manon (author), van den Bulk, Jitske (author), Ruano, Dina (author), Wessels, L.F.A. (author)DNA mismatch repair-deficient (MMR-d) cancers present an abundance of neoantigens that is thought to explain their exceptional responsiveness to immune checkpoint blockade (ICB)<sup>1,2</sup>. Here, in contrast to other cancer types<sup>3–5</sup>, we observed that 20 out of 21 (95%) MMR-d cancers with genomic inactivation of β2-microglobulin ...journal article 2023
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de Vries, N.L. (author), Van Unen, Vincent (author), Ijsselsteijn, Marieke E. (author), Abdelaal, T.R.M. (author), Van Der Breggen, Ruud (author), Farina Sarasqueta, Arantza (author), Mahfouz, A.M.E.T.A. (author), Peeters, Koen C.M.J. (author), Höllt, T. (author), Lelieveldt, B.P.F. (author), Koning, Frits (author), De Miranda, Noel F.C.C. (author)Objective: A comprehensive understanding of anticancer immune responses is paramount for the optimal application and development of cancer immunotherapies. We unravelled local and systemic immune profiles in patients with colorectal cancer (CRC) by high-dimensional analysis to provide an unbiased characterisation of the immune contexture of...journal article 2019