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de Visser, H.M. (author), Korthagen, NM (author), Müller, C. (author), Ramakers, R.M. (author), Krijger, G.C. (author), Lafeber, F.P.J.G. (author), Beekman, F.J. (author), Mastbergen, S.C. (author), Weinans, Harrie (author)Objective. To evaluate the presence and localization of folate receptor expressing macrophages in the rat groove model of osteoarthritis and determine the suitability of a new folate conjugate with albumin-binding entity (cm09) for in vivo SPECT (single-photon emission computed tomography) analysis. Design. In male Wistar rats, local cartilage...journal article 2018
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Wassink, J. (author), Krijger, M. (author)A capital of 60 billion in sewer drains lies buried in the Netherlands. These drains must gradually be replaced, but where to start? New inspection techniques may provide the answer.journal article 2015
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Jansen, D.R. (author), Krijger, G.C. (author), Kolar, Z.I. (author), Zeevaart, J.R. (author)The invention relates to a method of producing radionuclides. According to the method, a target medium comprising at least a target nuclide material is irradiated in an irradiation zone with neutron irradiation. Radionuclides form in the target nuclide material as a result of the irradiation, and at least some of the formed radionuclides are...patent 2011
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Bongers, WA. (author), Van Beveren, V. (author), Thoen, D.J. (author), Nuij, P.J.W.M. (author), De Baar, M.R. (author), Donné, A.J.H. (author), Westerhof, E. (author), Goede, A.P.H. (author), Krijger, B. (author), Van den Berg, M.A. (author), Kantor, M. (author), Graswinckel, M.F. (author), Hennen, B.A. (author), Schüller, F.C. (author)An intermediate frequency (IF) band digitizing radiometer system in the 100–200 GHz frequency range has been developed for Tokamak diagnostics and control, and other fields of research which require a high flexibility in frequency resolution combined with a large bandwidth and the retrieval of the full wave information of the mm-wave signals...journal article 2011
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Brasser, H.J. (author), Van der Strate, H.J. (author), Gieskes, W.W.C. (author), Krijger, G.C. (author), Vrieling, E.G. (author), Wolterbeek, H.T. (author)During valve formation of the siliceous frustules of diatoms, bulk uptake of silicic acid and its subsequent transport through the cell is required before it can be deposited in the silica deposition vesicle (SDV). It has been assumed that transport takes place via silicon transporters (SITs), but if that were the case a control mechanism would...journal article 2010
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Sevcenco, A.M. (author), Bevers, L.E. (author), Pinkse, M.W.H. (author), Krijger, G.C. (author), Wolterbeek, H.T. (author), Verhaert, P.D.E.M. (author), Hagen, W.R. (author), Hagedoorn, P.L. (author)The hyperthermophilic archaeon Pyrococcus furiosus expresses five aldehyde oxidoreductase (AOR) enzymes, all containing a tungsto-bispterin cofactor. The growth of this organism is fully dependent on the presence of tungsten in the growth medium. Previous studies have suggested that molybdenum is not incorporated in the active site of these...journal article 2010
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Brasser, H.J. (author), Gürbo?a, G. (author), Kroon, J.J. (author), Kolar, Z.I. (author), Wolterbeek, H.T. (author), Volkers, K.J. (author), Krijger, G.C. (author)No-carrier added 31Si was produced by 31P(n,p)31Si in the nuclear reactor of the Delft University of Technology. Several methods were investigated to remove the side product 32P, and the chemical form of 31Si was investigated. All methods except one gave good results. Anion exchange with Dowex resin gave the best results in activity...journal article 2010
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Sevcenco, A.M. (author), Krijger, G. (author), Pinkse, M. (author), Verhaert, P.D.E.M. (author), Hagen, W.R. (author), Hagedoorn, P.L. (author)A combination of techniques to separate and quantify the native proteins associated with a particular transition metal ion from a cellular system has been developed. The procedure involves four steps: (1) labeling of the target proteins with a suitable short-lived radioisotope (suitable isotopes are Cu-64, Cu-67, W-187, Mo-99, Zn-69, Mn-56, Ni...journal article 2009
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- Vente, M.A.D. (author), De Wit, T.C. (author), Van den Bosch, M.A.A.J. (author), Bult, W. (author), Seevinck, P.R. (author), Zonnenberg, B.A. (author), De Jong, H.W.A.M. (author), Krijger, G.C. (author), Bakker, C.J.G. (author), Van Het Schip, A.D. (author), Nijsen, J.F.W. (author) journal article 2009
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Hattink, J. (author), Celis, N. (author), De Boeck, G. (author), Krijger, G.C. (author), Blust, R. (author)Radio-caesium is an important radionuclide released considering food and feed products. In aquatic environments caesium tends to accumulate in fish, both through its diet and its gills. This presentation discusses the caesium accumulation in fish living in estuaries. The aim of this work is to conclude on the importance of potential uptake...journal article 2009
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Vente, M.A.D. (author), Nijsen, J.F.W. (author), De Roos, R. (author), Van Steenbergen, M.J. (author), Kaaijk, C.N.J. (author), Koster-Ammerlaan, M.J.J. (author), De Leege, P.F.A. (author), Hennink, W.E. (author), Van het Schip, A.D. (author), Krijger, G.C. (author)Poly(L-lactic acid) microspheres loaded with holmium-166 acetylacetonate (166Ho-PLLA-MS) are a novel microdevice for intra-arterial radioembolization in patients with unresectable liver malignancies. The neutron activation in a nuclear reactor, in particular the gamma heating, damages the 166Ho-PLLA-MS. The degree of damage is dependent on the...journal article 2009
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Brasser, H.J. (author), Krijger, G.C. (author), Wolterbeek, H.T. (author)Silicon is involved in numerous important structural and functional roles in a wide range of organisms, including diatoms, plants, and humans, but clear mechanisms have been discovered only in diatoms and sponges. Silicate availability influences metal concentrations within various cell- and tissue-types, but a mechanism has not been discovered...journal article 2008
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Vente, M.A.D. (author), Nijsen, J.F.W. (author), De Wit, T.C. (author), Seppenwoolde, J.H. (author), Krijger, G.C. (author), Seevinck, P.R. (author), Huisman, A. (author), Zonneneberg, B.A. (author), Van den Ingh, T.S.G.A.M. (author), Van het Schip, A.D. (author)Purpose The aim of this study is to evaluate the toxicity of holmium-166 poly(l-lactic acid) microspheres administered into the hepatic artery in pigs. Methods Healthy pigs (20–30 kg) were injected into the hepatic artery with holmium-165-loaded microspheres (165HoMS; n?=?5) or with holmium-166-loaded microspheres (166HoMS; n?=?13). The...journal article 2008
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- Krijger, Jan Willem (author) master thesis 2008
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- Krijger, D. (author) master thesis 2008
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- Tai, S.L. (author), Daran-Lapujade, P. (author), Luttik, M.A. (author), Walsh, M.C. (author), Diderich, J.A. (author), Krijger, G.C. (author), Van Gulik, W.M. (author), Pronk, J.T. (author), Daran, J.M. (author) journal article 2007
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Zielhuis, S.W. (author), Seppenwoolde, J.H. (author), Mateus, V.A.P. (author), Bakker, C.J.G. (author), Krijger, G.C. (author), Storm, G. (author), Zonnenberg, B.A. (author), Van het Schip, A.D. (author), Koning, G.A. (author), Nijsen, J.F.W. (author)Many advanced molecular imaging agents are currently being investigated preclinically. Especially, liposomes, have proven to be very promising carrier systems for diagnostic agents for use in single-photon emission computed tomography (SPECT) or magnetic resonance imaging (MRI), as well as for therapeutic agents to treat diseases such as cancer....journal article 2006
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- Krijger, G.C. (author) doctoral thesis 1999
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Krijger, G.C. (author), Claessens, H.A. (author), Wolterbeek, H.T. (author)The present paper addresses the potential use of capillary zone electrophoresis (CZE) as an analytical tool in 99- technetium speciation studies. In order to optimise sampling, storage and analytical procedures, the three marker compounds 99mTcO4-, 99mTc-DTPA and 99mTc-citrate were synthesised and used in test-measurements with CZE. The results...journal article 1996
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Bult, W. (author), Seevinck, P.R. (author), Krijger, G.C. (author), Visser, T. (author), Kroon-Batenburg, L.M.J. (author), Bakker, C.J.G. (author), Hennink, W.E. (author), Van het Schip, A.D. (author), Nijsen, J.F.W. (author)Purpose The aim of this study was to develop microspheres with an ultra high holmium content which can be neutron activated for radioablation of malignancies. These microspheres are proposed to be delivered selectively through either intratumoral injections into solid tumors or administered via an intravascularly placed catheter. Methods...journal article