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Wesseling, B. (author), de Bok, M.A. (author), Van den Berg, M. (author), van der Beek, J. (author)Rijkswaterstaat gebruikt het goederenvervoermodel BasGoed om lange termijn prognoses te maken van het goederenvervoer. Economische verwachtingen spelen hierbij een belangrijke rol. Het model BasGoed begint dan ook met een module waarin de economische groei bepaald wordt en vervolgens vertaald wordt naar de hoeveelheid vervoerde goederen. De...conference paper 2023
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Liefaard, Marte C. (author), Moore, Kat S. (author), Mulder, Lennart (author), van den Broek, Daan (author), Wesseling, Jelle (author), Sonke, Gabe S. (author), Wessels, L.F.A. (author), Rookus, Matti (author), Lips, Esther H. (author)In this article the data availability statement was incorrectly given. “EGAS0000100682” should have been “EGAS00001006821”. The correct statement as follows. The datasets generated during and/or analysed during the current study are deposited at the European Genome-phenome Archive (EGA) under the accession numbers EGAS00001006821 and...journal article 2023
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Janssen, Matthijs J. (author), Wesseling, Joeri (author), Torrens, Jonas (author), Weber, K. Matthias (author), Penna, C.C.R. (author), Klerkx, Laurens (author)Recent times have seen the rediscovery and adaptation of mission-oriented innovation policies (MIPs) for driving transformative change. While such policies seek to mobilise and align stakeholders, little is known about how missions feature in policy coordination processes. We argue that to facilitate the still troublesome operationalisation of...journal article 2023
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Liefaard, Marte C. (author), Moore, Kat S. (author), Mulder, Lennart (author), van den Broek, Daan (author), Wesseling, Jelle (author), Sonke, Gabe S. (author), Wessels, L.F.A. (author), Rookus, Matti (author), Lips, Esther H. (author)Background: Studies have shown that blood platelets contain tumour-specific mRNA profiles tumour-educated platelets (TEPs). Here, we aim to train a TEP-based breast cancer detection classifier. Methods: Platelet mRNA was sequenced from 266 women with stage I–IV breast cancer and 212 female controls from 6 hospitals. A particle swarm optimised...journal article 2023
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de Bok, M.A. (author), de Jong, Gerard (author), Wesseling, Bart (author), Meurs, Henk (author), Van Bekkum, Peter (author), Mijjer, Peter (author), Bakker, Dick (author), Veger, Teun (author)In 2017, the newly installed Dutch government announced in its coalition agreement to introduce a distancebased heavy goods vehicle charge, similar to the charges levied in other European countries. To study the possible transport impacts, we applied available models and methods in preparation for the introduction of this truck charge in the...journal article 2022
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Harlaar, J. (author), Macri, E.M. (author), Wesseling, M.G.H. (author)Osteoarthritis (OA) has a complex, heterogeneous and only partly understood etiology. There is a definite role of joint cartilage pathomechanics in originating and progressing of the disease. Although it is still not identified precisely enough to design or select targeted treatments, the progress of this year's research demonstrates that...review 2022
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Ragusi, Max A.A. (author), Bismeijer, Tycho (author), van der Velden, Bas H.M. (author), Loo, Claudette E. (author), Canisius, Sander (author), Wesseling, Jelle (author), Wessels, L.F.A. (author), Elias, Sjoerd G. (author), Gilhuijs, Kenneth G.A. (author)Purpose: To assess whether contralateral parenchymal enhancement (CPE) on MRI is associated with gene expression pathways in ER+/HER2-breast cancer, and if so, whether such pathways are related to survival. Methods: Preoperative breast MRIs were analyzed of early ER+/HER2-breast cancer patients eligible for breast-conserving surgery included...journal article 2021
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Kainz, Hans (author), Wesseling, M.G.H. (author), Jonkers, Ilse (author)Background: Musculoskeletal modelling is used to assess musculoskeletal loading during gait. Linear scaling methods are used to personalize generic models to each participant's anthropometry. This approach introduces simplifications, especially when used in paediatric and/or pathological populations. This study aimed to compare results from...journal article 2021
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Wesseling, Bart (author), de Bok, M.A. (author), Spruijt, John (author), Usmani, Omar (author), van Bree, Thijmen (author)A transition from the use of conventional energy carriers to more sustainable alternatives is an important policy objective to mitigate the impact of our energy consumption on earth’s climate. This transition involves changes in the use of commodities in freight transport. This paper addresses how we improved the strategic freight transport...conference paper 2020
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Mirakhorlo, M. (author), Van Beek, N. (author), Wesseling, M. (author), Maas, H. (author), Veeger, H.E.J. (author), Jonkers, I. (author)To improve our understanding on the neuromechanics of finger movements, a comprehensive musculoskeletal model is needed. The aim of this study was to build a musculoskeletal model of the hand and wrist, based on one consistent data set of the relevant anatomical parameters. We built and tested a model including the hand and wrist segments, as...journal article 2018
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de Bok, M.A. (author), Wesseling, Bart (author), Kiel, Jan (author), Miete, Onno (author), Francke, Jan (author)Strategic freight transport models can be used for a quantitative analysis of long term forecasts. This paper discusses an analysis of the bandwidth of freight transport forecasts for The Netherlands with the strategic freight transport model ‘BasGoed’. This model was developed over the past years as a basic model, satisfying the needs of policy...journal article 2018
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Snelder, M. (author), Wesseling, B. (author), van Arem, B. (author), Hertogh, M.J.C.M. (author)When infrastructures projects are evaluated, it is not only important to evaluate them with models that represent the average daily situation, but also to evaluate them in case of irregular situations like incidents. This becomes especially relevant when various project alternatives are expected to show significantly different scores in case...journal article 2017
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Quaeghebeur, Erik (author), Wesseling, C. (author), Beauxis-Aussalet, E. (author), Piovesan, T. (author), Sterkenburg, T. (author)We present an interface for eliciting sets of acceptable gambles on a three-outcome possibility space, discuss an experiment conducted for testing this interface, and present the results of this experiment. Sets of acceptable gambles form a representation for imprecise probabilities that is close to human behavior and eliciting them directly may...journal article 2017
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Lips, Esther H. (author), Michaut, Magali (author), Hoogstraat, Marlous (author), Mulder, Lennart (author), Besselink, Nicole J.M. (author), Koudijs, Marco J. (author), Cuppen, Edwin (author), Voest, Emile E. (author), Bernards, Rene (author), Nederlof, Petra M. (author), Wesseling, Jelle (author), Rodenhuis, Sjoerd (author), Wessels, L.F.A. (author)Introduction<br/>In triple negative breast cancers (TNBC) the initial response to chemotherapy is often favorable, but relapse and chemotherapy resistance frequently occur in advanced disease. Hence there is an urgent need for targeted treatments in this breast cancer subtype. In the current study we deep sequenced DNA of tumors prior to...journal article 2015
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Vollebergh, M.A. (author), Klijn, C. (author), Schouten, P.C. (author), Wesseling, J. (author), Israeli, D. (author), Ylstra, B. (author), Wessels, L.F.A. (author), Jonkers, J. (author), Linn, S.C. (author)Lymph-node metastasis (LNM) predict high recurrence rates in breast cancer patients. Systemic treatment aims to eliminate (micro)metastatic cells. However decisions regarding systemic treatment depend largely on clinical and molecular characteristics of primary tumours. It remains, however, unclear to what extent metastases resemble the cognate...journal article 2014
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Vollebergh, M.A. (author), Lips, E.H. (author), Nederlof, P.M. (author), Wessels, L.F.A. (author), Wesseling, J. (author), Van de Vijver, M.J. (author), De vries, E.G.E. (author), Van Tinteren, H. (author), Jonkers, J. (author), Hauptman, M. (author), Rodenhuis, S. (author), Linn, S.C. (author)Introduction: BRCA-mutated breast cancer cells lack the DNA-repair mechanism homologous recombination that is required for error-free DNA double-strand break (DSB) repair. Homologous recombination deficiency (HRD) may cause hypersensitivity to DNA DSB-inducing agents, such as bifunctional alkylating agents and platinum salts. HRD can be caused...journal article 2014
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Oostindie, K. (author), Wesseling, J.G. (author), Ritsema, C.J. (author)In deze studie is onderzocht of een normering voor de belastingsituatie droogte kan worden opgesteld, uit het oogpunt van de verdroging van een veenkade en rekening houdend met het waterafstotend gedrag van veen. Ook is onderzocht of op basis van genormeerde droogteperioden een aanzet kan worden gegeven voor de schematisering van de freatische...report 2011
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- Wesseling, P. (author) public lecture 2007
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- Van der Heul, D.R. (author), Vuik, C. (author), Wesseling, P. (author) report 2000
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- Wesseling, J.W. (author) report 1999