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Ouyang, B. (author), Li, Yanlu (author), Kruidhof, Marten (author), Horsten, R.C. (author), Baets, Roel (author), van Dongen, K.W.A. (author), Caro-Schuurman, J. (author)We report a highly sensitive ultrasound sensor based on an integrated photonics silicon Mach-Zehnder interferometer (MZI). One arm of the MZI is located on a thin membrane, acting as the sensing part of the device. Ultrasound waves excite the membrane's vibrational mode, thus inducing modulation of the MZI transmission. The measured sensor...conference paper 2020
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Rikkert, L. G. (author), Beekman, P. (author), Caro-Schuurman, J. (author), Coumans, F. A.W. (author), Enciso-Martinez, A. (author), Jenster, G. (author), Le Gac, S. (author), Lee, W. (author), Loozen, G.B. (author)Extracellular vesicles (EVs) have great potential as biomarkers since their composition and concentration in biofluids are disease state dependent and their cargo can contain disease-related information. Large tumor-derived EVs (tdEVs, >1μm) in blood from cancer patients are associated with poor outcome, and changes in their number can be...journal article 2020
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Loozen, G.B. (author), Karuna, A. (author), Rafiee Fanood, M.M. (author), Schreuder, Erik (author), Caro-Schuurman, J. (author)We realized integrated photonics multi-waveguide devices for optical trapping and Raman spectroscopy of particles in a fluid. In these devices, multiple beams directed towards the device center lead to a local field enhancement around this center and thus counteract the effect of light concentration near the facets, which is a disadvantage of...journal article 2020
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Ouyang, B. (author), Xing, Yufei (author), Bogaerts, Wim (author), Caro-Schuurman, J. (author)We propose a design method for silicon ring resonators (RRs) with a free spectral range (FSR) insensitive to fabrication variations. Two waveguide-core widths are used in the RR, with opposite signs of the group-index derivative with respect to the width. This results in cancellation of the width-dependent FSR changes. The systematic...journal article 2019
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Ouyang, B. (author), Haverdings, Michael (author), Horsten, R.C. (author), Kruidhof, Marten (author), Kat, Pim (author), Caro-Schuurman, J. (author)We present a compact integrated photonics interrogator for a ring-resonator (RR) ultrasound sensor, the so-called MediGator. The MediGator consists of a special light source and an InP Mach-Zehnder interferometer (MZI) with a 3 × 3 multi-mode interferometer. Miniaturization of the MZI to chip size enables high temperature stability and...journal article 2019
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Loozen, G.B. (author), Caro-Schuurman, J. (author)The application of on-chip optical trapping and Raman spectroscopy using a dual-waveguide trap has so far been limited to relatively big synthetic and biological particles (e.g., polystyrene beads and blood cells). Here, from simulations, we present the capabilities of dual-waveguide traps built from composite SiO<sub>2</sub>-Si<sub>3</sub>N...journal article 2018
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Grillo Peternella, F. (author), Ouyang, B. (author), Horsten, R.C. (author), Haverdings, Michael (author), Kat, Pim (author), Caro-Schuurman, J. (author)We experimentally demonstrate an interrogation procedure of a ring-resonator ultrasound sensor using a fiber Mach-Zehnder interferometer (MZI). The sensor comprises a silicon ring resonator (RR) located on a silicon-oxide membrane, designed to have its lowest vibrational mode in the MHz range, which is the range of intravascular ultrasound (IVUS...journal article 2017