A multi-axis robot-based bioprinting system supporting natural cell function preservation and cardiac tissue fabrication

Despite the recent advances in artificial tissue and organ engineering, how to generate large size viable and functional complex organs still remains as a grand challenge for regenerative medicine. Three-dimensional bioprinting has demonstrated its advantages as one of the major methods in fabricating simple tissues, yet it still faces...

Analysis of Railway Ballasted Track Stiffness and Behavior with a Hybrid Discrete-Continuum Approach

Railway ballasted track stiffness is an important indicator to identify supporting condition that ensures that the facility is well designed and functioned. Although many studies have been performed on track stiffness based on experimental tests and finite-element methods, the factors influencing the track stiffness have not been completely...

Coupled discrete-continuum approach for railway ballast track and subgrade macro-meso analysis

This paper presents a multi-layer railway ballast track and substructure model, where a coupled discrete and continuous method is used for macro-meso dynamic behaviour analysis under moving wheel loads. In this coupled model, the discrete element method (DEM) is utilised to build the superstructure of the ballast track (i.e. rail, fastener,...

Macro-meso dynamic analysis of railway transition zone: Hybrid DEM/FDM simulation and experimental validation

To probe into the mechanical behaviour of railway transition zone from the macro-meso aspects, a numerical model of transition zone is built that hybrids the Discrete Element Method (DEM) and Finite Difference Method (FDM). The DEM is utilised to simulate the ballast bed and sleeper, because it can consider the realistic ballast shapes and...