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Nouri Goushki, M. (author), Eijkel, B.I.M. (author), Minneboo, M.B. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Modulation of the immune response following the implantation of biomaterials can have beneficial effects on bone regeneration. This involves complex interactions between the inflammatory and osteogenic cells. Therefore, the study of cell-cell interactions using direct co-culture models integrated with biomaterials is of great interest. This...journal article 2022
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Shakerin, Sajad (author), Sanjari, Mehdi (author), Pirgazi, H. (author), Amirkhiz, Babak Shalchi (author), Mohammadi, Mohsen (author)Maraging steel (MS1)-tool steel (P20) bimetals additively manufactured using the laser powder bed fusion technique were studied under different heat treatment cycles and loading conditions. The hardening of P20 and aging of MS1 were performed sequentially on the hybrid samples. The interfacial characteristics and microstructural evolution of...journal article 2022
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Tankova, T. (author), Andrade, David (author), Branco, Ricardo (author), Zhu, Carlos (author), Rodrigues, Dulce (author), Simões da Silva, Luís (author)This paper analyses the microstructural and mechanical properties of carbon steel coupons produced by CMT-WAAM. The strategy adopted in the fabrication of the test specimens using a robotised facility is explained. Then, the results of the mechanical characterization performed using as-built and machined samples, extracted in several...journal article 2022
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van de Ven, E.A. (author), Maas, Robert (author), Ayas, C. (author), Langelaar, Matthijs (author), van Keulen, A. (author)Although additive manufacturing (AM) allows for a large design freedom, there are some manufacturing limitations that have to be taken into consideration. One of the most restricting design rules is the minimum allowable overhang angle. To make topology optimization suitable for AM, several algorithms have been published to enforce a minimum...journal article 2021
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Oldhoff, M. G.E. (author), Mirzaali, Mohammad J. (author), Tümer, N. (author), Zhou, J. (author), Zadpoor, A.A. (author)Additive manufacturing (AM) offers great design freedom that enables objects with desired unique and complex geometry and topology to be readily and cost-effectively fabricated. The overall benefits of AM are well known, such as increased material and resource efficiency, enhanced design and production flexibility, the ability to create...journal article 2021
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Kerstens, Fabio (author), Cervone, A. (author), Gradl, P.R. (author)High performance liquid rocket engines require cooling to maintain structural integrity of the combustion chamber which is exposed to high thermal and environmental loads. For many systems, this is achieved by means of regenerative cooling, where a coolant flows through passages around the chamber wall whilst extracting heat from the wall. A...journal article 2021
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Misiun, Grzegorz (author), van de Ven, E.A. (author), Langelaar, Matthijs (author), Geijselaers, Hubert (author), van Keulen, A. (author), van den Boogaard, Ton (author), Ayas, C. (author)An important cause of failure in powder bed additive manufacturing is the distortion of the part due to thermal shrinkage during printing and the relaxation of residual stresses after its release from the base plate. In this paper, Additive Manufacturing simulations are coupled with Topology Optimization in order to generate designs that are...journal article 2021
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Tselikos, Georgios (author), Rasul, Shahid (author), Groen, W.A. (author), Li, Chunchun (author), Khaliq, Jibran (author)Three-dimensional printing-based additive manufacturing has emerged as a new frontier in materials science, with applications in the production of functionalized polymeric-based hybrid composites for various applications. In this work, a novel conceptual design was conceived in which an AC electric field was integrated into a commercial 3D...journal article 2021
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Kolken, H.M.A. (author), Garcia, A. Fontecha (author), Du Plessis, A. (author), Rans, C.D. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)Meta-biomaterials offer a promising route towards the development of life-lasting implants. The concept aims to achieve solutions that are ordinarily impossible, by offering a unique combination of mechanical, mass transport, and biological properties through the optimization of their small-scale geometrical and topological designs. In this...journal article 2021
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van Hengel, I.A.J. (author), Lacin, M. (author), Minneboo, M.B. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)Surface biofunctionalization is frequently applied to enhance the functionality and longevity of orthopedic implants. Here, we investigated the osteogenic effects of additively manufactured porous Ti6Al4V implants whose surfaces were biofunctionalized using plasma electrolytic oxidation (PEO) in Ca/P-based electrolytes with or without...journal article 2021
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Shakil, S. I. (author), Hadadzadeh, A. (author), Shalchi Amirkhiz, B. (author), Pirgazi, H. (author), Mohammadi, M. (author), Haghshenas, M. (author)This study aims at assessing the effect of solution heat treatment (at a temperature just below the eutectic temperature) followed by various cooling rates on the microstructure and mechanical properties of additively manufactured AlSi10Mg and the cast counterpart. The mechanical properties were evaluated using a depth-sensing nanoindentation...journal article 2021
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Sobota, V.C.M. (author), van de Kaa, G. (author), Luomaranta, Toni (author), Martinsuo, Miia (author), Ortt, J.R. (author)Purpose: This paper addresses the most important factors for the selection of additive manufacturing (AM) technology as a method of production of metal parts. AM creates objects by adding material layer by layer based on 3D models. At present, interest in AM is high as it is hoped that AM contributes to the competitiveness of Western...journal article 2020
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Fleischer, J.C. (author), Diehl, J.C. (author), Wauben, L.S.G.L. (author), Dankelman, J. (author)Three-dimensional (3D) printing may be a solution to shortages of equipment and spare parts in the healthcare sector of low- and middle-income countries (LMICs). Polylactic acid (PLA) for 3D printing is widely available and biocompatible, but there is a gap in knowledge concerning its compatibility with chemical disinfectants. In this study, 3D...journal article 2020
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Kolken, H.M.A. (author), Lietaert, K. (author), van der Sloten, T. (author), Pouran, B. (author), Meynen, A. (author), Van Loock, G. (author), Weinans, Harrie (author), Scheys, L. (author), Zadpoor, A.A. (author)The innovative design of orthopedic implants could play an important role in the development of life-lasting implants, by improving both primary and secondary implant fixations. The concept of meta-biomaterials aims to achieve a unique combination of mechanical, mass transport, and biological properties through optimized topological design of...journal article 2020
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van Hengel, I.A.J. (author), Gelderman, F. S.A. (author), Athanasiadis, S. (author), Minneboo, M.B. (author), Weinans, Harrie (author), Fluit, A. C. (author), van der Eerden, B.C.J. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)The holy grail of orthopedic implant design is to ward off both aseptic and septic loosening for long enough that the implant outlives the patient. Questing this holy grail is feasible only if orthopedic biomaterials possess a long list of functionalities that enable them to discharge the onerous task of permanently replacing the native bone...journal article 2020
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van de Ven, E.A. (author), Maas, Robert (author), Ayas, C. (author), Langelaar, Matthijs (author), van Keulen, A. (author)It is attractive to combine topology optimization (TO) with additive manufacturing (AM), due to the design freedom provided by AM, and the increased performance that can be achieved with TO. One important aspect is to include the design rules associated with the process restrictions of AM to prevent the requirement of relatively large support...journal article 2020
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van Hengel, I.A.J. (author), Putra, N.E. (author), Tierolf, M. W.A.M. (author), Minneboo, M.B. (author), Fluit, A. C. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)Antibiotic-resistant bacteria are frequently involved in implant-associated infections (IAIs), making the treatment of these infections even more challenging. Therefore, multifunctional implant surfaces that simultaneously possess antibacterial activity and induce osseointegration are highly desired in order to prevent IAIs. The incorporation...journal article 2020
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Kuipers, T. (author), Doubrovski, E.L. (author), Wu, J. (author), Wang, C.C. (author)3D printing techniques such as Fused Deposition Modeling (FDM) have enabled the fabrication of complex geometry quickly and cheaply. Objects are produced by filling (a portion of) the 2D polygons of consecutive layers with contour-parallel extrusion toolpaths. Uniform width toolpaths consisting of inward offsets from the outline polygons...journal article 2020
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Karami, K. (author), Blok, A. (author), Weber, L.R.M. (author), Ahmadi, S.M. (author), Petrov, R.H. (author), Nikolic, Ksenija (author), Borisov, E.V. (author), Leeflang, M.A. (author), Ayas, C. (author), Zadpoor, A.A. (author), Mehdipour, M. (author), Reinton, T.E. (author), Popovich, V. (author)Additive manufacturing technologies in general and laser powder bed fusion (L-PBF) in particular have been on the rise in different applications, including biomedical implants. The effects of the various L-PBF process parameters on the microstructure and properties of Ti6Al4V lattice structures have been studied before. However, the...journal article 2020
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Li, Y. (author), Pavanram, P. (author), Zhou, J. (author), Lietaert, K. (author), Taheri, P. (author), Li, W. (author), San, H. (author), Leeflang, M.A. (author), Mol, J.M.C. (author), Jahr, H. (author), Zadpoor, A.A. (author)Additively manufacturing (AM) opens up the possibility for biodegradable metals to possess uniquely combined characteristics that are desired for bone substitution, including bone-mimicking mechanical properties, topologically ordered porous structure, pore interconnectivity and biodegradability. Zinc is considered to be one of the promising...journal article 2020