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Putra, N.E. (author), Zhou, J. (author), Zadpoor, A.A. (author)The need for sustainable development has never been more urgent, as the world continues to struggle with environmental challenges, such as climate change, pollution, and dwindling natural resources. The use of renewable and recycled waste materials as a source of raw materials for biomaterials and tissue engineering is a promising avenue for...review 2023
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Li, Y. (author), Pavanram, P. (author), Bühring, J. (author), Rütten, S. (author), Schröder, K. U. (author), Zhou, J. (author), Pufe, T. (author), Wang, L. . (author), Zadpoor, A.A. (author), Jahr, H. (author)Additively manufactured (AM) degradable porous metallic biomaterials offer unique opportunities for satisfying the design requirements of an ideal bone substitute. Among the currently available biodegradable metals, iron has the highest elastic modulus, meaning that it would benefit the most from porous design. Given the successful...journal article 2023
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van Kootwijk, A. (author), Jonker, B. P. (author), Wolvius, E. B. (author), Cruz Saldivar, M. (author), Leeflang, M.A. (author), Zhou, J. (author), Tümer, N. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)Objective: Mandibular reconstruction using patient-specific cage implants is a promising alternative to the vascularized free flap reconstruction for nonirradiated patients with adequate soft tissues, or for patients whose clinical condition is not conducive to microsurgical reconstruction. This study aimed to assess the biomechanical...journal article 2023
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Mirzaali, Mohammad J. (author), Shahriari, N.S. (author), Zhou, J. (author), Zadpoor, A.A. (author)Additive manufacturing (AM) technologies, particularly those based on powder bed fusion (PBF), most notably, selective laser melting (SLM) for metals, have in recent years emerged as unique fabrication methods for patient-specific implants made of metals and their alloys. The ability to manufacture complex geometries together with the other...book chapter 2023
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A multibody kinematic system approach for the design of shape-morphing mechanism-based metamaterialsde Jong, P.H. (author), Schwab, A.L. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)Shape-morphing structures have the ability to adapt to various target shapes, offering significant advantages for many applications. However, predicting their behavior presents challenges. Here, we present a method to assess the shape-matching behavior of shape-morphing structures using a multibody systems approach wherein the structure is...journal article 2023
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Garner, E. (author), Wu, J. (author), Zadpoor, A.A. (author)Patient-specific implants offer a host of benefits over their generic counterparts. Nonetheless, the design and optimization of these components present several technical challenges, among them being the need to ensure their insertability into the host bone tissue. This presents a significant challenge due to the tight-fitting nature of the...journal article 2023
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Prins, Jonne T.H. (author), Van Wijck, Suzanne F.M. (author), Leeflang, M.A. (author), Kleinrensink, Gert Jan (author), Lottenberg, Lawrence (author), de la Santa Barajas, Pablo Moreno (author), Van Huijstee, Pieter J. (author), Vermeulen, Jefrey (author), Verhofstad, Michael H.J. (author), Zadpoor, A.A. (author), Wijffels, Mathieu M.E. (author), Van Lieshout, Esther M.M. (author)Background: The primary aim of this study was to determine and compare the biomechanical properties of a fractured or intact rib after implant fixation on an embalmed thorax. Methods: Five systems were fixated on the bilateral fractured or intact (randomly allocated) 6th to 10th rib of five post-mortem embalmed human specimens. Each rib...journal article 2023
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Zadpoor, A.A. (author), Mirzaali, Mohammad J. (author), Valdevit, Lorenzo (author), Hopkins, Jonathan B. (author)Metamaterials are engineered materials with unusual, unique properties and advanced functionalities that are a direct consequence of their microarchitecture. While initial properties and functionalities were limited to optics and electromagnetism, many novel categories of metamaterials that have applications in many different areas of...contribution to periodical 2023
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Moosabeiki, Vahid (author), de Winter, N. (author), Cruz Saldivar, M. (author), Leeflang, M.A. (author), Witbreuk, M. M.E.H. (author), Lagerburg, V. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)Orthopedic plates are commonly used after osteotomies for temporary fixation of bones. Patient-specific plates have recently emerged as a promising fixation device. However, it is unclear how various strategies used for the design of such plates perform in comparison with each other. Here, we compare the biomechanical performance of 3D...journal article 2023
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Callens, S.J.P. (author), Fan, D. (author), van Hengel, I.A.J. (author), Minneboo, M.B. (author), Diaz Payno, P.J. (author), Stevens, Molly M. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Individual cells and multicellular systems respond to cell-scale curvatures in their environments, guiding migration, orientation, and tissue formation. However, it remains largely unclear how cells collectively explore and pattern complex landscapes with curvature gradients across the Euclidean and non-Euclidean spectra. Here, we show that...journal article 2023
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Putra, N.E. (author), Leeflang, M.A. (author), Ducret, Verena (author), Patrulea, Viorica (author), Fratila-Apachitei, E.L. (author), Perron, Karl (author), Ye, Hua (author), Zhou, J. (author), Apachitei, I. (author), Zadpoor, A.A. (author)Implant-associated infections are highly challenging to treat, particularly with the emergence of multidrug-resistant microbials. Effective preventive action is desired to be at the implant site. Surface biofunctionalization of implants through Ag-doping has demonstrated potent antibacterial results. However, it may adversely affect bone...journal article 2022
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Dong, J. (author), Tümer, N. (author), Leeflang, M.A. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zadpoor, A.A. (author), Zhou, J. (author)Porous biodegradable Mg and its alloys are considered to have a great potential to serve as ideal bone substitutes. The recent progress in additive manufacturing (AM) has prompted its application to fabricate Mg scaffolds with geometrically ordered porous structures. Extrusion-based AM, followed by debinding and sintering, has been recently...journal article 2022
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Ganjian, M. (author), Modaresifar, K. (author), Rompolas, Dionysios (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Developing high-throughput nanopatterning techniques that also allow for precise control over the dimensions of the fabricated features is essential for the study of cell-nanopattern interactions. Here, we developed a process that fulfills both of these criteria. Firstly, we used electron-beam lithography (EBL) to fabricate precisely...journal article 2022
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Putra, N.E. (author), Tigrine, A. (author), Aksakal, S. (author), de la Rosa, V. R. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zhou, J. (author), Zadpoor, A.A. (author)Additively manufacturing of porous iron offers a unique opportunity to increase its biodegradation rate by taking advantage of arbitrarily complex porous structures. Nevertheless, achieving the required biodegradation profile remains challenging due to the natural passivation of iron that decrease the biodegradation rate. Moreover, the...journal article 2022
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Kolken, H.M.A. (author), Garcia, A. Fontecha (author), Plessis, A. Du (author), Meynen, A. (author), Rans, C.D. (author), Scheys, L. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)The fatigue performance of additively manufactured auxetic meta-biomaterials made from commercially pure titanium has been studied only recently. While certain assumptions have been made regarding the mechanisms underlying their fatigue failure, the exact mechanisms are not researched yet. Here, we studied the mechanisms of crack formation...journal article 2022
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Nouri Goushki, M. (author), Eijkel, B.I.M. (author), Minneboo, M.B. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Modulation of the immune response following the implantation of biomaterials can have beneficial effects on bone regeneration. This involves complex interactions between the inflammatory and osteogenic cells. Therefore, the study of cell-cell interactions using direct co-culture models integrated with biomaterials is of great interest. This...journal article 2022
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Ganjian, M. (author), Janbaz, S. (author), van Manen, T. (author), Tümer, N. (author), Modaresifar, K. (author), Minneboo, M.B. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)We designed and fabricated a simple setup for the controlled crumpling of nanopatterned, surface-porous flat metallic sheets for the fabrication of volume-porous biomaterials and showed that crumpling can be considered as an efficient alternative to origami-inspired folding. Before crumpling, laser cutting was used to introduce pores to the...journal article 2022
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Pahlavani, H. (author), Amani, M. (author), Cruz Saldivar, M. (author), Zhou, J. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)Emerging multi-material 3D printing techniques enables the rational design of metamaterials with not only complex geometries but also arbitrary distributions of multiple materials within those geometries, yielding unique combinations of elastic properties. However, discovering the rare designs that lead to highly unusual combinations of...journal article 2022
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Angeloni, L. (author), Popa, Bogdan (author), Nouri Goushki, M. (author), Minneboo, M.B. (author), Zadpoor, A.A. (author), Ghatkesar, M.K. (author), Fratila-Apachitei, E.L. (author)Physical patterns represent potential surface cues for promoting osteogenic differentiation of stem cells and improving osseointegration of orthopedic implants. Understanding the early cell–surface interactions and their effects on late cellular functions is essential for a rational design of such topographies, yet still elusive. In this work...journal article 2022
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Kubo, Yusuke (author), Beckmann, Rainer (author), Pahlavani, H. (author), Cruz Saldivar, M. (author), Szymanski, Katharina (author), Leeflang, M.A. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author), Wruck, Christoph Jan (author), Jahr, H. (author)Background: Nuclear factor erythroid 2–related factor 2 (Nrf2) is a crucial transcription factor for cellular redox homeostasis. The association of Nrf2 with elderly female osteoporotic has yet to be fully described. The aim was to elucidate a potential age-dependent Nrf2 contribution to female osteoporosis in mice. Methods: Eighteen female...journal article 2022