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Langeveld, Simone A.G. (author), Meijlink, Bram (author), Beekers, Inés (author), Olthof, Mark (author), van der Steen, A.F.W. (author), de Jong, N. (author), Kooiman, Klazina (author)Phospholipid-coated targeted microbubbles are used for ultrasound molecular imaging and locally enhanced drug delivery, with the binding efficacy being an important trait. The use of organic solvent in microbubble production makes the difference between a heterogeneous or homogeneous ligand distribution. This study demonstrates the effect of...journal article 2022
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Schang, Christelle (author), Crosbie, Nicolas D. (author), Nolan, Monica (author), Poon, Rachael (author), WANG, M. (author), Jex, Aaron (author), John, Nijoy (author), Baker, Louise (author), Langeveld, J.G. (author)The shedding of pathogens by infected humans enables the use of sewage monitoring to conduct wastewater-based epidemiology (WBE). Although most WBE studies use data from large sewage treatment plants, timely data from smaller catchments are needed for targeted public health action. Traditional sampling methods, like autosamplers or grab...journal article 2021
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van der Werf, Job (author), Kapelan, Z. (author), Langeveld, J.G. (author)To evaluate the performance of Real Time Control (RTC) of urban drainage systems (UDS) a comparison is made with the pre-RTC situation, making the RTC performance dependent on the functioning of the UDS prior to implementation. To standardise things, a generalised baseline is formulated here as the operation with optimal static settings of the...journal article 2021
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Kouijzer, Joop J.P. (author), Lattwein, Kirby R. (author), Beekers, Inés (author), Langeveld, Simone A.G. (author), Leon-Grooters, Mariël (author), Strub, Jean Marc (author), Oliva, Estefania (author), de Jong, N. (author), van der Steen, A.F.W. (author)Bacterial biofilms are a huge burden on our healthcare systems worldwide. The lack of specificity in diagnostic and treatment possibilities result in difficult-to-treat and persistent infections. The aim of this in vitro study was to investigate if microbubbles targeted specifically to bacteria in biofilms could be used both for diagnosis as...journal article 2021
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Vollaers, Vita (author), Nieuwenhuis, E.M. (author), van de Ven, F.H.M. (author), Langeveld, J.G. (author)Despite being widely implemented, sustainable urban drainage systems (SUDS) do not always function flawlessly. While SUDS have been tested extensively and seem to perform well on a laboratory or pilot scale, practitioners’ experience is different: failures in SUDS occur regularly in practice, resulting in malfunctioning systems, water...journal article 2021
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Makris, K. (author), Langeveld, J.G. (author), Clemens-Meyer, François H.L.R. (author), Watts, Joanna (author), Begum, Hasina (author), Horoshenkov, Kirill V. (author)This article explores the potential of vibro-acoustics to detect physical ageing of plastic pipes. For this purpose, two different topics are combined: the ability of vibro-acoustics to estimate the storage modulus of a plastic pipe, and the sensitivity of the estimated storage modulus to changes due to ageing. Concerning the first topic, a...journal article 2023
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Langeveld, J.G. (author), Schilperoort, Remy (author), Heijnen, Leo (author), Elsinga, Goffe (author), Schapendonk, Claudia E.M. (author), Fanoy, Ewout (author), de Schepper, Evelien I.T. (author), Koopmans, Marion P.G. (author), de Graaf, Miranda (author), Medema, G.J. (author)Over the course of the Corona Virus Disease-19 (COVID-19) pandemic in 2020–2022, monitoring of the severe acute respiratory syndrome coronavirus 2 ribonucleic acid (SARS-CoV-2 RNA) in wastewater has rapidly evolved into a supplementary surveillance instrument for public health. Short term trends (2 weeks) are used as a basis for policy and...journal article 2023
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Meijer, D.H. (author), Korving, J.L. (author), Langeveld, J.G. (author), Clemens-Meyer, François (author)Urban drainage systems are composed of subsystems. The ratio of the storage and discharge capacities of the subsystems determines the performance. The performance of the urban water system may deteriorate as a result of the change in the ratio of storage to discharge capacity due to aging, urbanisation and climate change. We developed the...journal article 2023
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Langeveld, J.G. (author), Post, Johan (author), Makris, K. (author), Palsma, Bert (author), Kuiper, Melanie (author), Liefting, Erik (author)The ecological state of receiving water bodies can be significantly influenced by organic micropollutants that are emitted via stormwater runoff. Reported efforts to quantify the emission of micropollutants mainly focus on sampling at combined sewer overflows and storm sewer outfalls, which can be challenging. An alternative method, called...journal article 2023
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de Graaf, Miranda (author), Langeveld, J.G. (author), Post, Johan (author), Carrizosa, Christian (author), Franz, Eelco (author), Izquierdo-Lara, Ray W. (author), Elsinga, Goffe (author), Heijnen, Leo (author), Medema, G.J. (author)Despite high vaccination rates in the Netherlands, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to circulate. Longitudinal sewage surveillance was implemented along with the notification of cases as two parts of the surveillance pyramid to validate the use of sewage for surveillance, as an early warning tool, and to...journal article 2023
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Langeveld, Simone A.G. (author), Beekers, Inés (author), Collado Lara, G. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Kooiman, Klazina (author)Phospholipid-coated microbubbles are ultrasound contrast agents that can be employed for ultrasound molecular imaging and drug delivery. For safe and effective implementation, microbubbles must respond uniformly and predictably to ultrasound. Therefore, we investigated how lipid handling and phase distribution affected the variability in the...journal article 2021
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Nieuwenhuis, E.M. (author), de Bruijn, J.A. (author), Cuppen, Eefje (author), Langeveld, J.G. (author)Urban water systems worldwide need integrated, cross-sectoral innovations to anticipate developments like climate change and population growth. Development and implementation of such innovations is challenging due to the operational and sectoral mindset of organizations in which these innovations take place. This study uses the concept of...journal article 2023
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van der Werf, Job (author), Kapelan, Z. (author), Langeveld, J.G. (author)Urban areas are constantly developing and thereby affect the local water cycle. Real-time control (RTC) strategies are used to operate urban drainage systems optimally during these transitions. This paper aims to develop a methodology to study the impacts of common gradual changes occurring in the urban environment (densification of the urban...journal article 2023
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van der Werf, Job (author), Kapelan, Z. (author), Langeveld, J.G. (author)Model Predictive Control (MPC) of Urban Drainage Systems (UDS) has been established as a cost-effective method to reduce pollution. However, the operation of large UDS (containing over 20 actuators) can only be optimized by oversimplifying the UDS dynamics, potentially leading to a decrease in performance and reduction in users' trust, thus...journal article 2023
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Daulat, Shamsuddin (author), Rokstad, Marius Møller (author), Bruaset, Stian (author), Langeveld, J.G. (author), Tscheikner-Gratl, F. (author)Small utilities often lack the required amount of data to train machine learning-based models to predict pipe failures, and hence are unable to harness the possibilities and predictive power of machine learning. This study evaluates the generalizability and transferability of a machine learning model to see if small utilities can benefit from...journal article 2023
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Makris, K. (author), Hoefeijzers, Bas (author), Seelen, Laura (author), Schilperoort, R.P.S. (author), Langeveld, J.G. (author)Urban water is a crucial element of cities for the purpose of events and recreation, raising concern over the water quality and related hygienic safety. In this study, a near real-time monitoring system of the β-d-glucuronidase activity, the BACTcontrol, was tested in the canals of Breda city in the Netherlands in order to gain insight in its...journal article 2023
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Schilperoort, Remy (author), Post, Johan (author), Klootwijk, Martijn (author), Hoefeijzers, Bas (author), Hof, Arjo (author), Palsma, Bert (author), Leenen, Imke (author), Makris, Konstantinos F. (author), Langeveld, J.G. (author)Illicit connections of wastewater to stormwater systems are the main drawback of separate sewer systems, as they lead to a direct discharge of untreated wastewater to the aquatic environment. Consequently, several inspection methods have been developed for detecting illicit connections. This study simultaneously applied several low- and high...journal article 2023
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Regueiro-Picallo, Manuel (author), Langeveld, J.G. (author), Wei, Haoyu (author), Bertrand-Krajewski, Jean Luc (author), Rieckermann, Jörg (author)Sediments in urban drainage systems (UDS) significantly impact their operation, so effective strategies are required to reduce their negative effects. Monitoring sediment accumulation provides valuable insights into sediment characteristics, sediment transport dynamics, and system performance. However, the effectiveness of monitoring systems...journal article 2024
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van Riel, W. (author), Post, J.A.B. (author), Langeveld, J.G. (author), Herder, P.M. (author), Clemens, F.H.L.R. (author)Operational decision-making processes for networked infrastructure management often occur as a multi-actor planning problem, implying these are based on negotiations between different stakeholders in addition to available system quality information. As such, does more accurate data about actual structural condition lead to other or better...journal article 2016
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Post, J.A.B. (author), Langeveld, J.G. (author), Clemens, F.H.L.R. (author)The performance of lateral house connections has a direct impact on sewer serviceability. Despite the potential consequences of a blockage, these components are generally maintained with a reactive approach. As inspection data on the condition of lateral house connections are scarce, this study adopts a statistical procedure to support...journal article 2016