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Mozaffarzadeh, M. (author), Moore, Colman (author), Golmoghani, Erfan Barzegar (author), Mantri, Yash (author), Hariri, Ali (author), Jorns, Alec (author), Fu, Lei (author), Verweij, M.D. (author), de Jong, N. (author)Simultaneous visualization of the teeth and periodontium is of significant clinical interest for image-based monitoring of periodontal health. We recently reported the application of a dual-modality photoacoustic-ultrasound (PA-US) imaging system for resolving periodontal anatomy and periodontal pocket depths in humans. This work utilized a...journal article 2021
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Collado Lara, G. (author), Heymans, Sophie V. (author), Rovituso, M. (author), Carlier, Bram (author), Toumia, Yosra (author), Verweij, M.D. (author), Vos, H.J. (author), de Jong, N. (author), Daeichin, V. (author)The potential of proton therapy to improve the conformity of the delivered dose to the tumor volume is currently limited by range uncertainties. Injectable superheated nanodroplets have recently been proposed for ultrasound-based in vivo range verification, as these vaporize into echogenic microbubbles on proton irradiation. In previous...journal article 2021
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Kim, Taehoon (author), Fool, F. (author), Simoes dos Santos, D. (author), Chang, Z.Y. (author), Noothout, E.C. (author), Vos, H.J. (author), Bosch, Johan G. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author)This paper presents an ultrasound transceiver application-specific integrated circuit (ASIC) directly integrated with an array of 12 × 80 piezoelectric transducer elements to enable next-generation ultrasound probes for 3D carotid artery imaging. The ASIC, implemented in a 0.18 µm high-voltage Bipolar-CMOS-DMOS (HV BCD) process, adopted a...journal article 2021
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van Willigen, D.M. (author), Kang, E. (author), Janjic, Jovana (author), Noothout, E.C. (author), Chang, Z.Y. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author)This article presents an application-specific integrated circuit (ASIC) designed for intra-vascular ultrasound imaging that interfaces 64 piezoelectric transducer elements to an imaging system using a single micro-coaxial cable. Thus, it allows a single-element transducer to be replaced by a transducer array to enable 3-D imaging. The 1.5-mm...journal article 2021
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Hakakzadeh, Soheil (author), Mozaffarzadeh, M. (author), Mostafavi, Seyed Masood (author), Amjadian, Mohammadreza (author), Kavehvash, Zahra (author), Verweij, M.D. (author), de Jong, N. (author)In circular photoacoustic computed tomography, for data acquisition, a single-element transducer rotates around the region of interest (ROI). Due to the limited acceptance angle of the finite size transducer, the reconstructed image becomes blurred, and tangential resolution/contrast degrades in off-center locations in the ROI. In this paper, we...conference paper 2021
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Simoes dos Santos, D. (author), Fool, F. (author), Kim, Taehoon (author), Noothout, E.C. (author), Vos, H.J. (author), Bosch, Johan G. (author), Pertijs, M.A.P. (author), Verweij, M.D. (author), de Jong, N. (author)Over the past decades, real-time three-dimensional (3D) medical ultrasound has attracted much attention since it enables clinicians to diagnose more accurately. This calls for ultrasound matrix transducers with a large number of elements, which can be interfaced with an application-specific integrated circuit (ASIC) for data reduction. An...conference paper 2021
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Mozaffarzadeh, M. (author), Verweij, M.D. (author), Daeichin, V. (author), de Jong, N. (author), Renaud, G.G.J. (author)Transcranial ultrasound imaging is a suitable technology for diagnosis of strokes as it is safe, portable, relatively inexpensive and available in emergency medicine services, however it currently offers poor image quality due to the phase aberration caused by the human skull. In this work, we evaluate an approach for two-dimensional...conference paper 2021
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Mozaffarzadeh, M. (author), Minonzio, C.G. (author), de Jong, N. (author), Verweij, M.D. (author), Hemm, Simone (author), Renaud, G.G.J. (author), Daeichin, V. (author)In the above article [1], we mentioned that the superposition of the different symmetric (S) modes in the frequencywavenumber (f-k) domain results in a high-intensity region where its slope corresponds to the longitudinal wave speed in the slab. However, we have recently understood that this highintensity region belongs to the propagation of...journal article 2020
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Beekers, D.I. (author), Vegter, Merel (author), Lattwein, Kirby R. (author), Mastik, Frits (author), Beurskens, Robert (author), van der Steen, A.F.W. (author), de Jong, N. (author), Verweij, M.D. (author), Kooiman, Klazina (author)Ultrasound insonification of microbubbles can locally increase vascular permeability to enhance drug delivery. To control and optimize the therapeutic potential, we need to better understand the underlying biological mechanisms of the drug delivery pathways. The aim of this in vitro study was to elucidate the microbubble-endothelial cell...journal article 2020
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Massaad Mouawad, J.M. (author), van Neer, P.L.M.J. (author), Willigen, D. M. van (author), Pertijs, M.A.P. (author), de Jong, N. (author), Verweij, M.D. (author)During ultrasonic clamp-on flow metering, Lamb waves propagating in the pipe wall may limit the measurement accuracy by introducing absolute errors in the flow estimates. Upon reception, these waves can interfere with the up and downstream waves refracting from the liquid, and disturb the measurement of the transit time difference that is used...journal article 2020
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Mozaffarzadeh, M. (author), Minonzio, C.G. (author), de Jong, N. (author), Verweij, M.D. (author), Hemm, Simone (author), Daeichin, V. (author)Phase aberration in transcranial ultrasound imaging (TUI) caused by the human skull leads to an inaccurate image reconstruction. In this article, we present a novel method for estimating the speed of sound and an adaptive beamforming technique for phase aberration correction in a flat polyvinylchloride (PVC) slab as a model for the human...journal article 2020
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Massaad Mouawad, J.M. (author), van Neer, P.L.M.J. (author), van Willigen, D.M. (author), Pertijs, M.A.P. (author), de Jong, N. (author), Verweij, M.D. (author)Current ultrasonic clamp-on flow meters are manually calibrated. This process is based on manual placement of two single-element transducers along a pipe wall. Due to the usually unknown pipe properties and inhomogeneities in the pipe geometry, the axial distance of the transducers needs to be manually calibrated to align the location of the...journal article 2020
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Sabbadini, A. (author), Keijzer, L.B.H. (author), Vos, H.J. (author), de Jong, N. (author), Verweij, M.D. (author)Shear wave elastography (SWE) might allow non-invasive assessment of cardiac stiffness by relating shear wave propagation speed to material properties. However, after aortic valve closure, when natural shear waves occur in the septal wall, the stiffness of the muscle decreases significantly, and the effects of such temporal variation of...journal article 2020
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Beekers, D.I. (author), Mastik, Frits (author), Beurskens, Robert (author), Tang, Phoei Ying (author), Vegter, Merel (author), van der Steen, A.F.W. (author), de Jong, N. (author), Verweij, M.D. (author), Kooiman, Klazina (author)Ultrasound insonification of microbubbles can locally enhance drug delivery, but the microbubble–cell interaction remains poorly understood. Because intracellular calcium (Ca<sub>i</sub> <sup>2+</sup>) is a key cellular regulator, unraveling the Ca<sub>i</sub> <sup>2+</sup> fluctuations caused by an oscillating microbubble provides crucial...journal article 2020
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Chen, Z. (author), Soozande, M. (author), Vos, H.J. (author), Bosch, J.G. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author)This article quantitatively analyzes the impact of bit errors in digitized RF data on ultrasound image quality. The quality of B-mode images in both linear array and phased array imaging is evaluated by means of three objective image quality metrics: peak signal-to-noise ratio, structural similarity index, and contrast-to-noise ratio, when...journal article 2020
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Mozaffarzadeh, M. (author), Soozande, M. (author), Fool, F. (author), Pertijs, M.A.P. (author), Vos, H.J. (author), Verweij, M.D. (author), Bosch, Johan G. (author), de Jong, N. (author)Recently, we realized a prototype matrix transducer consisting of 48 rows of 80 elements on top of a tiled set of Application Specific Integrated Circuits (ASICs) implementing a row-level control connecting one transmit/receive channel to an arbitrary subset of elements per row. A fully sampled array data acquisition is implemented by a...journal article 2020
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van Willigen, D.M. (author), Neer, Paul L.M.J. van (author), Massaad Mouawad, J.M. (author), de Jong, N. (author), Verweij, M.D. (author), Pertijs, M.A.P. (author)Transit-time ultrasonic flow meters are widely used in industry to measure fluid flow. In practice ultrasonic flow meters either show a zero-flow error or suffer from a significant random error due to a limited signal-to-noise ratio, requiring a significant amount of averaging to achieve good precision. This work presents a method that minimizes...journal article 2020
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van Willigen, D.M. (author), Mozaffarzadeh, M. (author), Noothout, E.C. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author), Daeichin, V. (author)This paper presents the integration steps towards a prototype forward-looking intra-vascular ultrasound probe. An ASIC (Application Specific Integrated Circuit) is laser cut to create a 1.6mm circular shaped die that can be integrated at the tip of a small catheter. The ASIC is designed such that it can be used to transmit and receive on 64...conference paper 2019
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Sabbadini, A. (author), Caenen, A.F.M. (author), Vos, H.J. (author), de Jong, N. (author), Verweij, M.D. (author)Shear Wave Elastography (SWE) has been proposed to investigate cardiac health by non-invasively monitoring tissue stiffness. Previous work has shown that the plate-like geometry of the Interventricular Septum (IVS) may result in a dispersion similar to Lamb waves, complicating the link between shear wave speed and cardiac stiffness. However, the...journal article 2019
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- Soozande, Mehdi (author), Ossenkoppele, B.W. (author), Hopf, Y.M. (author), Pertijs, M.A.P. (author), Verweij, M.D. (author), Vos, H.J. (author), Bosch, J.G. (author), de Jong, N. (author) poster 2019