Single-Electron Occupation in Quantum Dot Arrays at Selectable Plunger Gate Voltage

The small footprint of semiconductor qubits is favorable for scalable quantum computing. However, their size also makes them sensitive to their local environment and variations in the gate structure. Currently, each device requires tailored gate voltages to confine a single charge per quantum dot, clearly challenging scalability. Here, we...

Graph-based identification of critical elements in urban water infrastructure

The purpose of this thesis was to develop and demonstrate methods for determining the criticality of elements in networks. The impact failures could have on the network performance was its primary focus. A second objective was to determine whether the developed method could be applied successfully based on network characteristics. To achieve...

Impact of the COVID-19 pandemic on the in-hospital diagnostic pathway of breast and colorectal cancer in the Netherlands: A population-based study

Background: In the Netherlands, the COVID-19 pandemic resulted in a temporary halt of population screening for cancer and limited hospital capacity for non-COVID care. We aimed to investigate the impact of the pandemic on the in-hospital diagnostic pathway of breast cancer (BC) and colorectal cancer (CRC). Methods: 71,159 BC and 48,900 CRC...

An integrated single-cell RNA-seq atlas of the mouse hypothalamic paraventricular nucleus links transcriptomic and functional types

The hypothalamic paraventricular nucleus (PVN) is a highly complex brain region that is crucial for homeostatic regulation through neuroendocrine signaling, outflow of the autonomic nervous system, and projections to other brain areas. In the past years, single-cell datasets of the hypothalamus have contributed immensely to the current...

Downsizing and the use of timber as embodied carbon reduction strategies for new-build housing: A partial life cycle assessment

The 2050 decarbonization goals coupled with the growing housing shortage in Europe intensify the pressure on new-build dwellings to enhance their energy performance. Beyond a zero operational energy, the focus has shifted towards reducing embodied carbon (EC). Against this backdrop, this study investigates the simultaneous impact of downsizing...

The value of a mobile educative Application additional to Standard counselling on aspirin Adherence in Pregnancy: the ASAP study, a randomised controlled trial

Objective: To assess the added value of a novel, mobile educative application to standard counselling on aspirin adherence during pregnancy versus standard counselling alone. Methods: Participants were randomly assigned for additional use of a mobile educative application or standard counselling alone. Main outcome measures were adherence to...

Low disorder and high valley splitting in silicon

The electrical characterisation of classical and quantum devices is a critical step in the development cycle of heterogeneous material stacks for semiconductor spin qubits. In the case of silicon, properties such as disorder and energy separation of conduction band valleys are commonly investigated individually upon modifications in selected...