- document
-
Gritsenko, A.A. (author), Nijkamp, J.F. (author), Reinders, M.J.T. (author), De Ridder, D. (author)Motivation: The increasing availability of second-generation highthroughput sequencing (HTS) technologies has sparked a growing interest in de novo genome sequencing. This in turn has fueled the need for reliable means of obtaining high-quality draft genomes from short-read sequencing data. The millions of reads usually involved in HTS...journal article 2012
- document
- Winterbach, W. (author), De Ridder, D. (author), Wang, H.J. (author), Reinders, M. (author), Van Mieghem, P. (author) conference paper 2012
- document
-
Van Geenhuizen, M.S. (author), Schoonman, J. (author), Reinders, A.H.M.E. (author)Places of large potentials of sustainable energy production and places of energy consumption are often very different and separated by large distances across the globe. This paper first discusses potentials of solar technology in terms of global availability using PV technology and actual energy production. Solar energy is widely under-used and...conference paper 2012
- document
-
Nikerel, I.E. (author), Berkhout, J. (author), Hu, F. (author), Teusink, B. (author), Reinders, M.J.T. (author), De Ridder, D. (author)Understanding cellular regulation of metabolism is a major challenge in systems biology. Thus far, the main assumption was that enzyme levels are key regulators in metabolic networks. However, regulation analysis recently showed that metabolism is rarely controlled via enzyme levels only, but through non-obvious combinations of hierarchical ...journal article 2012
- document
-
Van Vliet, M.H. (author), Horlings, H.M. (author), Van de Vijver, M.J. (author), Reinders, M.J.T. (author), Wessels, L.F.A. (author)Breast cancer outcome can be predicted using models derived from gene expression data or clinical data. Only a few studies have created a single prediction model using both gene expression and clinical data. These studies often remain inconclusive regarding an obtained improvement in prediction performance. We rigorously compare three different...journal article 2012
- document
-
Alves, H. (author), Van Ginkel, J. (author), Groen, N. (author), Hulsman, N. (author), Mentink, A. (author), Reinders, M.J.T. (author), Van Blitterswijk, C. (author), De Boer, J. (author)Human aging is associated with loss of function and regenerative capacity. Human bone marrow derived mesenchymal stromal cells (hMSCs) are involved in tissue regeneration, evidenced by their capacity to differentiate into several lineages and therefore are considered the golden standard for cell-based regeneration therapy. Tissue maintenance and...journal article 2012
- document
-
Flipsen, S.F.J. (author), Geraedts, J.M.P. (author), Reinders, A.H.M.E. (author), Bakker, C.A. (author), Dafnomilis, I. (author), Gudadhe, A. (author)Smartphone use has increased at a phenomenal pace worldwide. In 2011 more smartphones have been sold than desktop pc’s, notebooks, netbooks and tablets together. The total worldwide smartphone sales reached 472 million units in 2011, and 149 million of them were sold in the fourth quarter of 2011. The smartphone is, like almost every other...conference paper 2012
- document
-
Viswanathan, B. (author), Reinders, A.H.M.E. (author), De Boer, D.K.G. (author), Ras, A. (author), Zahn, H. (author), Desmet, L. (author)Solar photovoltaic outdoor lighting applications usually comprise flat plate PV modules mounted on top of a light pole. In our paper instead, it is thought of to design the light pole as a luminescent solar concentrator photovoltaic (LSC-PV) module with solar cell strips and hence reduce costs of silicon solar cells because concentration effects...conference paper 2012
- document
-
Van den Berg, B.A. (author), Reinders, M.J.T. (author), Hulsman, M. (author), Wu, L. (author), Pel, H.J. (author), Roubos, J.A. (author), De Ridder, D. (author)Protein sequence features are explored in relation to the production of over-expressed extracellular proteins by fungi. Knowledge on features influencing protein production and secretion could be employed to improve enzyme production levels in industrial bioprocesses via protein engineering. A large set, over 600 homologous and nearly 2,000...journal article 2012
- document
-
Apostolou, G. (author), Reinders, A.H.M.E. (author)In this paper 80 commercially available PV products have been analysed. The data set comprises 46 low power PV products in the range of 0 to 17 Wp and 34 PV products with a power of 17 Wp up to 27 kWp. The goal of our study is to investigate and evaluate features of PV products that are available on the market now and to present features that...conference paper 2012
- document
-
Van Geenhuizen, M.S. (author), Schoonman, J. (author), Reinders, A.H.M.E. (author)Places of large potentials of sustainable energy production and places of energy consumption are often very different and separated by large distances across the globe. This paper first discusses potentials of solar technology in terms of global availability using PV technology and actual energy production. Solar energy is widely under-used and...conference paper 2012
- document
-
Entrop, A.G. (author), Reinders, A.H.M.E. (author)Er is een experiment uitgevoerd met vier betonnen vloeren in een semiadiabatische omgeving. Twee vloeren bevatten PCMs en, ter referentie, twee vloeren geen PCMs. De opstelling moest op schaal een woning voorstellen met een raam op het zuiden. De omgevingscondities en de temperatuurontwikkelingen in de vloeren en boxen werden gemonitord. Het...journal article 2012
- document
- Gehrmann, T. (author), Pelkmans, Jordi F. (author), Lugones, Luis G. (author), Wösten, Han A.B. (author), Reinders, M.J.T. (author) poster 2013
- document
-
Mahfouz, A.M.E.T.A. (author), Ziats, Mark N. (author), Rennert, Owen M. (author), Lelieveldt, B.P.F. (author), Reinders, M.J.T. (author)We analyzed the spatial-temporal co-expression relationships of 455 genes previously implicated in Autism spectrum disorder (ASD) using the BrainSpan transcriptome atlas. Understanding how the heterogenous set of ASD-related genes contribute to normal brain development helps identifying cellular/molecular processes which are commonly disrupted...poster 2013
- document
-
van den Berg, B.A. (author), Thornton, JM (author), Reinders, M.J.T. (author), de Ridder, D. (author), Beer, TAP (author)Our aim is to prioritize human missense mutations by their probability of being disease causing. Such a computational method could be used to obtain a reduced set of mutations with a relatively large fraction of disease related mutations, thereby aiding in the search for this type of mutation within a large mutation set.<br/><br/>Whereas a range...poster 2013
- document
-
Babaei, S. (author), Hulsman, M. (author), Reinders, M.J.T. (author), De Ridder, J. (author)Background Delineating the molecular drivers of cancer, i.e. determining cancer genes and the pathways which they deregulate, is an important challenge in cancer research. In this study, we aim to identify pathways of frequently mutated genes by exploiting their network neighborhood encoded in the protein-protein interaction network. To this end...journal article 2013
- document
-
Van Dyk, E. (author), Reinders, M.J.T. (author), Wessels, L.F.A. (author)Tumor formation is partially driven by DNA copy number changes, which are typically measured using array comparative genomic hybridization, SNP arrays and DNA sequencing platforms. Many techniques are available for detecting recurring aberrations across multiple tumor samples, including CMAR, STAC, GISTIC and KC SMART. GISTIC is widely used and...journal article 2013
- document
-
Klijn, C. (author), Koudijs, M.J. (author), Kool, J. (author), Ten Hoeve, J. (author), Boer, M. (author), De Moes, J. (author), Akhtar, W. (author), Van Miltenburg, M. (author), Vendel-Zwaagstra, A. (author), Reinders, M.J.T. (author), Adams, D.J. (author), Van Lohuizen, M. (author), Hilkens, J. (author), Wessels, L.F.A. (author), Jonkers, J. (author)Cancer develops through a multistep process in which normal cells progress to malignant tumors via the evolution of their genomes as a result of the acquisition of mutations in cancer driver genes. The number, identity and mode of action of cancer driver genes, and how they contribute to tumor evolution is largely unknown. This study deployed...journal article 2013
- document
-
Winterbach, W. (author), Van Mieghem, P. (author), Reinders, M. (author), Wang, H. (author), De Ridder, D. (author)Molecular interactions are often represented as network models which have become the common language of many areas of biology. Graphs serve as convenient mathematical representations of network models and have themselves become objects of study. Their topology has been intensively researched over the last decade after evidence was found that...journal article 2013
- document
-
Taskesen, E. (author), Hoogeboezem, R. (author), Delwel, R. (author), Reinders, M.J.T. (author)Probing protein-deoxyribonucleic acid (DNA) is gaining popularity as it sheds light on molecular mechanisms that regulate the expression of genes. Currently, tiling-arrays and next-generation sequencing technology can be used to measure these interactions. Both methods generate a signal over the genome in which contiguous regions of peaks on the...journal article 2013