- document
-
Dijkstra, Y.M. (author), Schuttelaars, H.M. (author), Schramkowski, G.P. (author), Brouwer, R.L. (author)Many estuaries are strongly modified by human interventions, including substantive channel deepening. In the Ems River Estuary (Germany and Netherlands), channel deepening between the 1960s and early 2000s coincided with an increase in the maximum near-bed suspended sediment concentration from moderate (∼1 kg/m <sup>3</sup> ) to high (>10...journal article 2019
- document
-
Dijkstra, Y.M. (author), Schuttelaars, H.M. (author), Schramkowski, G.P. (author)Many estuaries are strongly deepened to improve navigation, with sometimes large and poorly understood consequences to suspended sediment dynamics. To improve understanding of such large changes, we study the Ems River Estuary, where a regime shift from low to high sediment concentrations was observed after deepening. The aim of this study is...journal article 2019
- document
-
Ypma, S.L. (author), Brüggemann, N. (author), Georgiou, S. (author), Spence, P. (author), Dijkstra, H. A. (author), Pietrzak, J.D. (author), Katsman, C.A. (author)The pathways and watermass transformation of the North Icelandic Irminger Current (NIIC) in the Nordic Seas are investigated by tracing the NIIC watermass in two ocean circulation models: the Modular Ocean Model (MOM) and the Parallel Ocean Program (POP). The two simulations use identical atmospheric forcing and have a horizontal resolution of 0...journal article 2019
- document
-
Dijkstra, Y.M. (author), Schuttelaars, H.M. (author), Schramkowski, G.P. (author)We investigate the hypothesis by Winterwerp and Wang (Ocean Dyn 63:1279–1292, 2013) that channel deepening in the Scheldt River Estuary could lead to a large increase in suspended sediment concentrations, with subsequent severe consequences to primary production and navigation. To this end, we use an idealised model to investigate the long...journal article 2019
- document
-
Dijkstra, Y.M. (author), Chant, Robert J. (author), Reinfelder, John R. (author)Phytoplankton biomass in estuaries is controlled by complex biological and chemical processes that control growth and mortality, and physical processes that control transport and dilution. The effects of these processes on phytoplankton blooms were systematically analyzed, focusing on identifying the dominant controlling factors out of river...journal article 2019
- document
-
Sayol España, J.M. (author), Dijkstra, Henk A. (author), Katsman, C.A. (author)Previous studies have indicated that most of the net sinking associated with the downward branch of the Atlantic Meridional Overturning Circulation (AMOC) must occur near the subpolar North Atlantic boundaries. In this work we have used monthly mean fields of a high-resolution ocean model (0.1 at the Equator) to quantify this sinking. To this...journal article 2019
- document
-
Vural Gursel, Iris (author), Dijkstra, Jan W. (author), Huijgen, Wouter J.J. (author), Ramirez, Andrea (author)This paper presents a techno-economic assessment of three novel routes for the production of bio-based aromatics from lignin. It aims to provide insights into their feasibility and hotspots at an early stage of development to guide further research and development and to facilitate commercialization. The lignin conversion routes are: (non...journal article 2019
- document
-
van der Boog, C.G. (author), de Jong, M. F. (author), Scheidat, M. (author), Leopold, M. F. (author), Geelhoed, S. C.V. (author), Schulz, K. (author), Pietrzak, J.D. (author), Katsman, C.A. (author), Dijkstra, H.A. (author)In the Caribbean Sea, mesoscale anticyclonic ocean eddies impact the local ecosystem by mixing of low salinity river outflow with the nutrient-rich waters upwelling along the Venezuelan and Colombian coast. To gain insight into the physics and the ecological impact of these anticyclones, we performed a combined hydrographic and biological...journal article 2019
- document
-
Ooft, Salo N. (author), Weeber, Fleur (author), Dijkstra, Krijn K. (author), McLean, Chelsea M. (author), Kaing, Sovann (author), van Werkhoven, Erik (author), Schipper, Luuk (author), Hoes, Louisa (author), Wessels, L.F.A. (author)There is a clear and unmet clinical need for biomarkers to predict responsiveness to chemotherapy for cancer. We developed an in vitro test based on patient-derived tumor organoids (PDOs) from metastatic lesions to identify nonresponders to standard-of-care chemotherapy in colorectal cancer (CRC). In a prospective clinical study, we show the...journal article 2019
- document
-
Hanssen, Lucien (author), Dijkstra, Anne M. (author), Sleenhoff, S. (author), Frewer, Lynn J. (author), Gutteling, Jan M. (author)Genetic Modification (GM) has been a topic of public debates during the 1990s and 2000s. In this paper we explore the relative importance of two hypothesized explanations for these controversies: (i) people's general attitude toward science and technology and (ii) their trust in governance, in GM actors, and in GM regulations, in explaining the...journal article 2018
- document
-
van Westen, René M. (author), Dijkstra, Henk A. (author), Klees, R. (author), Riva, R.E.M. (author), Slobbe, D.C. (author), van der Boog, C.G. (author), Katsman, C.A. (author), Candy, A.S. (author), Pietrzak, J.D. (author), Zijlema, Marcel (author), James, Rebecca K. (author), Bouma, Tjeerd J. (author)The Yucatan Channel connects the Caribbean Sea with the Gulf of Mexico and is the main outflow region of the Caribbean Sea. Moorings in the Yucatan Channel show high-frequent variability in kinetic energy (50–100 days) and transport (20–40 days), but the physical mechanisms controlling this variability are poorly understood. In this study, we...journal article 2018
- document
-
Dekker, Mark M. (author), van Lieshout, Rolf N. (author), Ball, Robin C. (author), Bouman, Paul C. (author), Dekker, Stefan C. (author), Dijkstra, Henk A. (author), Goverde, R.M.P. (author), Huisman, Dennis (author), Panja, Deb (author), Schaafsma, Alfons A.M. (author), van den Akker, Marjan (author)Railway systems occasionally get into a state of out-of-control, meaning that there is barely any train is running, even though the required resources (infrastructure, rolling stock and crew) are available. These situations can either be caused by large disruptions or unexpected propagation and accumulation of delays. Because of the large number...conference paper 2018
- document
-
Lundberg, AB (author), Broere, W. (author), Dijkstra, J. (author)An instrumented model pile has been realized to study the displacement pile installation effects in sand in physical model tests. The system includes a model pile, instrumented with axial and horizontal contact stress sensors, and a corresponding calibration apparatus. The development of the instrumented model pile, including numerical analysis...conference paper 2018
- document
-
Gaio, N. (author), Waafi, A. (author), Vlaming, M.L.H. (author), Boschman, E. (author), Dijkstra, P. (author), Nacken, O. (author), Braam, S.R. (author), Boucsein, C. (author), Sarro, Pasqualina M (author), Dekker, R. (author)This work presents the first multi-well plate that allows for simultaneous mechanical stimulation and electrical monitoring of multiple in-vitro cell cultures in parallel. Each well of the plate is equipped with an Organ-on-Chip (OOC) device consisting of a stretchable micro-electrode array (MEA). For the first time, a film assisted molding ...conference paper 2018
- document
-
Katsman, C.A. (author), Drijfhout, S. S. (author), Dijkstra, H. A. (author), Spall, M. A. (author)We investigate the characteristics of the sinking of dense waters in the North Atlantic Ocean that constitute the downwelling limb of the Atlantic Meridional Overturning Circulation (AMOC) as simulated by two global ocean models: an eddy-permitting model at 1/4° resolution and its coarser 1° counterpart. In line with simple geostrophic...journal article 2018
- document
-
Brouwer, R.L. (author), Schramkowski, G.P. (author), Dijkstra, Y.M. (author), Schuttelaars, H.M. (author)Using an idealized width-averaged process-based model, the role of a mud pool on the bed and time-varying river discharge on the trapping of fine sediment is systematically investigated. For this purpose, a dynamically and physically motivated description of erodibility is presented, which relates the amount of sediment on the bed to the...journal article 2018
- document
-
Vrijhoef, R. (author), Dijkstra, Jan Tjerk (author), Koutamanis, A. (author)This paper presents a research endeavouring to model site work in a 4D BIM model. Next simulations are performed with this model in 5 scenarios including specific interventions in work organisation, notably changing positons of facilities for site workers. A case study has been done in a construction project in the Netherlands. The research has...conference paper 2018
- document
-
Broere, W. (author), Dijkstra, J. (author), Ottolini, M (author)A cost effective method to measure pore water pressures in mixed granular media is described using 40 miniature MEMS pore pressure transducers. High accuracy in a single point is exchanged for lower accuracy full field measurements adjacent to the strongbox wall. The system is easily de-aired and calibrated due to the fact that the transducers...conference paper 2018
- document
-
Abdelmoula, Walid M. (author), Pezzotti, N. (author), Höllt, T. (author), Dijkstra, Jouke (author), Vilanova Bartroli, A. (author), McDonnell, Liam A. (author), Lelieveldt, B.P.F. (author)Technological advances in mass spectrometry imaging (MSI) have contributed to growing interest in 3D MSI. However, the large size of 3D MSI data sets has made their efficient analysis and visualization and the identification of informative molecular patterns computationally challenging. Hierarchical stochastic neighbor embedding (HSNE), a...journal article 2018
- document
-
Liu, Shengnan (author), Dzyubachyk, Oleh (author), Eggermont, Jeroen (author), Nakatani, Shimpei (author), Lelieveldt, B.P.F. (author), Dijkstra, J. (author)Purpose: Intravascular optical coherence tomography (OCT) is widely used for analysis of the coronary artery disease. Its high spatial resolution allows for visualization of arterial tissue components in detail. There are different OCT systems on the market, each of which produces data characterized by its own intensity range and distribution...journal article 2018