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Viho, Eva M.G. (author), Buurstede, Jacobus C. (author), Mahfouz, A.M.E.T.A. (author), Koorneef, Lisa L. (author), Van Weert, Lisa T.C.M. (author), Houtman, René (author), Hunt, Hazel J. (author), Kroon, Jan (author), Meijer, Onno C. (author)Glucocorticoid hormones have important effects on brain function in the context of acute and chronic stress. Many of these are mediated by the glucocorticoid receptor (GR). GR has transcriptional activity which is highly context-specific and differs between tissues and even between cell types. The outcome of GR-mediated transcription depends...journal article 2019
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van den Brom, P.I. (author), Meijer, A. (author), Visscher, H.J. (author)Thermal renovations are considered to be an effective measure to reduce residential energy consumption. However, they often result in lower-than-expected energy savings. In this paper, we investigate some parameters that influence the probability on lower-than-expected energy savings. We do this by comparing actual pre- and post-renovation...journal article 2019
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Koorneef, Lisa L. (author), Bogaards, Marit (author), Reinders, M.J.T. (author), Meijer, Onno C. (author), Mahfouz, A.M.E.T.A. (author)Metabolic status impacts on the emotional brain to induce behavior that maintains energy balance. While hunger suppresses the fear circuitry to promote explorative food-seeking behavior, satiety or obesity may increase fear to prevent unnecessary risk-taking. Here we aimed to unravel which metabolic factors, that transfer information about...journal article 2018
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Meijer, F.M. (author), Straub, A. (author), Mlecnik, E. (author)The housing sector is responsible for a more than a quarter of the total final energy consumption in the EU. As the majority (70%) of the EU-housing stock is owner occupied and largely consists of single family dwellings it is understandable that many countries focus their energy saving policies on homeowners. Complementary to the national...journal article 2018
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van Uffelen, N. (author), Costan, Laura (author), Devine, Matthew J. (author), van Dinther, Maud (author), Hendrickx, Louise (author), Meijer, Job (author), Zenner, Eline (author)Since the introduction of non-invasive prenatal testing (NIPT) in Belgium in 2013, expectant parents have had access to a new efficient and reliable test for genetic abnormalities, including trisomy 13, 18 and 21. In 2017, the Belgian government decided to cover over 95% of the cost for all women who choose to take this test. In this context, a...journal article 2018
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Roungas, V. (author), Meijer, Sebastiaan (author), Verbraeck, A. (author)Thirty years of research on validation and verification have returned a plethora of methods and statistical techniques through methodological and case studies. It is, however, this abundance of methods and techniques that poses a major challenge. Due to time and budget constraints, it is impossible to apply all the available methods and...journal article 2018
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Meijer, D.H. (author), van Bijnen, J.A.C. (author), Langeveld, J.G. (author), Korving, J.L. (author), Post, J.A.B. (author), Clemens, F.H.L.R. (author)Underground water infrastructure is essential for life in cities. The aging of these infrastructures requires maintenance strategies to maintain a minimum service level. Not all elements are equally important for the functioning of the infrastructure as a whole. Identifying the most critical elements in a network is crucial for formulating...journal article 2018
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Lei, Q. (author), Chen, G. (author), Meijer, Jonathan (author), Wisse, M. (author)Increasing grasping efficiency is very important for the robots to grasp unknown objects especially subjected to unfamiliar environments. To achieve this, a new algorithm is proposed based on the C-shape configuration. Specifically, the geometric model of the used under-actuated gripper is approximated as a C-shape. To obtain an appropriate...journal article 2018
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Roungas, V. (author), Meijer, Sebastiaan (author), Verbraeck, A. (author)Simulations are the core of every railway system. Changes in the timetable and the infrastructure, or even in the internal processes of a railway company should be, and usually are, first tested through simulations. Given their significance and potential impact, simulations should be primarily validated; validation ensures-at least to some...journal article 2018
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Wang, Guijie (author), Heidari, A. (author), Makinwa, K.A.A. (author), Meijer, G.C.M. (author)This paper describes the design of a precision bipolar junction transistor based temperature sensor implemented in standard 0.7-μmCMOS technology. It employs substrate p-n-ps as sensing elements,which makes it insensitive<br/>to the effects of mechanical (packaging) stress and facilitates the use of low-cost packaging technologies. The sensor...journal article 2017
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Hoes, O.A.C. (author), Meijer, LJJ (author), van der Ent, R.J. (author), van de Giesen, N.C. (author)Population growth, increasing energy demand and the depletion of fossil fuel reserves necessitate a search for sustainable alternatives for electricity generation. Hydropower could replace a large part of the contribution of gas and oil to the present energy mix. However, previous high-resolution estimates of hydropower potential have been local...journal article 2017
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Meijer, F.M. (author), Visscher, H.J. (author)Purpose: This paper aims to evaluate the quality control systems for constructions in seven countries in Europe with the purpose to trace innovative approaches and best practices that can serve as examples for other countries. Design/methodology/approach: The paper is based on a series of research projects carried out over a number of years....journal article 2017
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van den Brom, P.I. (author), Meijer, A. (author), Visscher, H.J. (author)The difference between actual and calculated energy is called the ‘energy-performance gap’. Possible explanations for this gap are construction mistakes, improper adjusting of equipment, excessive simplification in simulation models and occupant behaviour. Many researchers and governmental institutions think the occupant is the main cause of...journal article 2017
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Lo, J.C. (author), Pluyter, K.R. (author), Meijer, S.A. (author)Objective:<br/>The aim of this study was to examine individual markers of resilience and obtain quantitative insights into the understanding and the implications of variation and expertise levels in train traffic operators’ goals and strategic mental models and their impact on performance.<br/>Background:<br/>The Dutch railways are one of the...journal article 2016
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van Lankveld, G. (author), Sehic, E. (author), Lo, J.C. (author), Meijer, S.A. (author)Background. The Dutch railway company ProRail is performing large-scale capacity upgrades to their infrastructure network. As part of these upgrades, ProRail uses gaming simulations to help prepare train traffic controllers for new infrastructure situations. Researching the validity of these gaming simulations is essential, since the conclusions...journal article 2016
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van den Hoogen, J. (author), Lo, J.C. (author), Meijer, S.A. (author)Background. Debriefing is an intrinsic part of games for learning and proper<br/>debriefing can also be beneficial to research games. However, the literature<br/>on how to debrief research games is sparse and only provides the professional<br/>with an abstract topic guide.<br/>Aim. The purpose of this study was to design a framework for the...journal article 2016
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Alsema, EA (author), Anink, D (author), Meijer, A. (author), Straub, A. (author), Donze, G (author)A new methodology is proposed to assess integral performance of building with respect to energy and materials requirement over the building life cycle. Because the method builds on existing methods for Energy Performance and Materials Performance of Buildings, as defined by Dutch National Building Code, it provides an easily applicable method...journal article 2016
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Rosenbaum, R.K. (author), Meijer, A. (author), Demou, E. (author), Hellweg, S. (author), Jolliet, O. (author), Lam, N.L. (author), Margni, M. (author), McKone, T.E. (author)Human exposure to indoor pollutant concentrations is receiving increasing interest in Life Cycle Assessment (LCA). We address this issue by incorporating an indoor compartment into the USEtox model, as well as by providing recommended parameter values for households in four different regions of the world differing geographically, economically,...journal article 2015
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Veneman, W.J. (author), De Sonneville, J. (author), Van der Kolk, K.J. (author), Ordas, A. (author), Al-Ars, Z. (author), Meijer, A.H. (author), Spaink, M.P. (author)We present a RNA deep sequencing (RNAseq) analysis of a comparison of the transcriptome responses to infection of zebrafish larvae with Staphylococcus epidermidis and Mycobacterium marinum bacteria. We show how our developed GeneTiles software can improve RNAseq analysis approaches by more confidently identifying a large set of markers upon...journal article 2014
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Hlotova, Y. (author), Cats, O. (author), Meijer, S.A. (author)Stress is an immense problem in modern society; approximately half of all occupational illnesses are directly or indirectly related to stress. The work of a bus driver is typically associated with high stress levels that negatively influence individual well-being as well as workforce management. The current study examined the impact of newly...journal article 2014